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Aldosterone synthase inhibition in humans

Nephrology, dialysis, transplantation, 2013-01, Vol.28 (1), p.36-43

2013

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Combined blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists

Circulation (New York, N.Y.), 2004-06, Vol.109 (21), p.2492-2499

2004

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Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

Clinical chemistry (Baltimore, Md.), 2009-05, Vol.55 (5), p.867-877

2009

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Aldosterone Synthase Inhibition With LCI699: A Proof-of-Concept Study in Patients With Primary Aldosteronism

Hypertension (Dallas, Tex. 1979), 2010-11, Vol.56 (5), p.831-838

2010

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Trends in Worldwide Research in Hypertension Over the Period 1999–2018: A Bibliometric Study

Hypertension (Dallas, Tex. 1979), 2020-11, Vol.76 (5), p.1649-1655

2020

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20-Year prevalence projections for dementia and impact of preventive policy about risk factors

European journal of epidemiology, 2013-06, Vol.28 (6), p.493-502

2013

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Sequential nephron blockade versus sequential renin–angiotensin system blockade in resistant hypertension: a prospective, randomized, open blinded endpoint study

Journal of hypertension, 2012-08, Vol.30 (8), p.1656-1664

2012

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Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study)

BMJ (Online), 2004-02, Vol.328 (7438), p.495-499

International edition, 2004

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Multiple Ascending Dose Study With the New Renin Inhibitor VTP-27999: Nephrocentric Consequences of Too Much Renin Inhibition

Hypertension (Dallas, Tex. 1979), 2014-05, Vol.63 (5), p.942-950

2014

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Prorenin Contributes to Angiotensin Peptide Formation in Transgenic Rats With Rat Prorenin Expression Targeted to the Liver

Hypertension (Dallas, Tex. 1979), 2009-12, Vol.54 (6), p.1248-1253

2009

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Effects of Oral and Transvaginal Ethinyl Estradiol on Hemostatic Factors and Hepatic Proteins in a Randomized, Crossover Study

The journal of clinical endocrinology and metabolism, 2007-06, Vol.92 (6), p.2074-2079

2007

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Serial left ventricular adaptations in world-class professional cyclists: implications for disease screening and follow-up

Journal of the American College of Cardiology, 2004-07, Vol.44 (1), p.144-149

2004

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Sequential comparison of aldosterone synthase inhibition and mineralocorticoid blockade in patients with primary aldosteronism

Journal of hypertension, 2013-03, Vol.31 (3), p.624-629

2013

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Effect of Contrasted Sodium Diets on the Pharmacokinetics and Pharmacodynamic Effects of Renin–Angiotensin System Blockers

Hypertension (Dallas, Tex. 1979), 2013-06, Vol.61 (6), p.1239-1245

2013

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Randomized Dose-Response Study of the New Dual Endothelin Receptor Antagonist Aprocitentan in Hypertension

Hypertension (Dallas, Tex. 1979), 2020-04, Vol.75 (4), p.956-965

2020

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Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition?

Journal of hypertension, 2006-06, Vol.24 (6), p.993-997

2006

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Integrating Drug Pharmacokinetics for Phenotyping Individual Renin Response to Angiotensin II Blockade in Humans

Hypertension (Dallas, Tex. 1979), 2004-04, Vol.43 (4), p.785-790

2004

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Clearance systems in the brain-implications for Alzheimer disease

Nature reviews. Neurology, 2015-08, Vol.11 (8), p.457

2015

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Investigation of aldosterone-synthase inhibition in rats

Journal of hypertension, 2006-06, Vol.24 (6), p.1147-1155

2006

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Eplerenone Survival Benefits in Heart Failure Patients Post-Myocardial Infarction Are Independent From its Diuretic and Potassium-Sparing Effects: Insights From an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) Substudy

Journal of the American College of Cardiology, 2011-11, Vol.58 (19), p.1958-1966

2011

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Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables

American journal of obstetrics and gynecology, 2006-07, Vol.195 (1), p.72-77

2006

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Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension: Results of a Randomized, Double-Blind, Placebo- and Active-Controlled Phase 2 Trial

Circulation (New York, N.Y.), 2011-11, Vol.124 (18), p.1945-1955

2011

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Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease

Journal of hypertension, 2010-07, Vol.28 (7), p.1429-1437

2010

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Inhibition of the renin–angiotensin–aldosterone system: is there room for dual blockade in the cardiorenal continuum?

Journal of hypertension, 2012-04, Vol.30 (4), p.647-654

2012

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Conformational changes in prorenin during renin inhibition in vitro and in vivo

Journal of hypertension, 2006-03, Vol.24 (3), p.529-534

2006

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Aldosterone synthase inhibition in humans

Combined blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists

Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

Aldosterone Synthase Inhibition With LCI699: A Proof-of-Concept Study in Patients With Primary Aldosteronism

Trends in Worldwide Research in Hypertension Over the Period 1999–2018: A Bibliometric Study

20-Year prevalence projections for dementia and impact of preventive policy about risk factors

Sequential nephron blockade versus sequential renin–angiotensin system blockade in resistant hypertension: a prospective, randomized, open blinded endpoint study

Effects of low dose ramipril on cardiovascular and renal outcomes in patients with type 2 diabetes and raised excretion of urinary albumin: randomised, double blind, placebo controlled trial (the DIABHYCAR study)

Multiple Ascending Dose Study With the New Renin Inhibitor VTP-27999: Nephrocentric Consequences of Too Much Renin Inhibition

Prorenin Contributes to Angiotensin Peptide Formation in Transgenic Rats With Rat Prorenin Expression Targeted to the Liver

Effects of Oral and Transvaginal Ethinyl Estradiol on Hemostatic Factors and Hepatic Proteins in a Randomized, Crossover Study

Serial left ventricular adaptations in world-class professional cyclists: implications for disease screening and follow-up

Sequential comparison of aldosterone synthase inhibition and mineralocorticoid blockade in patients with primary aldosteronism

Effect of Contrasted Sodium Diets on the Pharmacokinetics and Pharmacodynamic Effects of Renin–Angiotensin System Blockers

Randomized Dose-Response Study of the New Dual Endothelin Receptor Antagonist Aprocitentan in Hypertension

Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition?

Integrating Drug Pharmacokinetics for Phenotyping Individual Renin Response to Angiotensin II Blockade in Humans

Clearance systems in the brain-implications for Alzheimer disease

Investigation of aldosterone-synthase inhibition in rats

Eplerenone Survival Benefits in Heart Failure Patients Post-Myocardial Infarction Are Independent From its Diuretic and Potassium-Sparing Effects: Insights From an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) Substudy

Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables

Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension: Results of a Randomized, Double-Blind, Placebo- and Active-Controlled Phase 2 Trial

Increased dietary NaCl potentiates the effects of elevated prorenin levels on blood pressure and organ disease

Inhibition of the renin–angiotensin–aldosterone system: is there room for dual blockade in the cardiorenal continuum?

Conformational changes in prorenin during renin inhibition in vitro and in vivo

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