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Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies

Pharmaceutical research, 2021-08, Vol.38 (8), p.1387-1395

2021

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PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates

Antimicrobial agents and chemotherapy, 2014-11, Vol.58 (11), p.6668-6674

2014

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KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate

The Journal of biological chemistry, 2021-01, Vol.296, p.100155-100155, Article 100155

2021

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A Mechanistic Understanding of Monoclonal Antibody Interfacial Protection by Hydrolytically Degraded Polysorbate 20 and 80 under IV Bag Conditions

Pharmaceutical research, 2022-03, Vol.39 (3), p.563-575

2022

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Protein conjugates and fusion proteins as ocular therapeutics

Drug discovery today, 2019-08, Vol.24 (8), p.1440-1445

2019

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Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 β-lactamase

The Journal of biological chemistry, 2021-01, Vol.296 (C), p.100799-100799, Article 100799

2021

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Lead Optimization Yields High Affinity Frizzled 7‑Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.7739-7750

2019

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β-Lactams Increase the Antibacterial Activity of Daptomycin against Clinical Methicillin-Resistant Staphylococcus aureus Strains and Prevent Selection of Daptomycin-Resistant Derivatives

Antimicrobial Agents and Chemotherapy, 2012-12, Vol.56 (12), p.6192-6200

2012

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VraSR Two-Component Regulatory System Contributes to mprF-Mediated Decreased Susceptibility to Daptomycin in In Vivo-Selected Clinical Strains of Methicillin-Resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2012-01, Vol.56 (1), p.92-102

2012

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Discovery of Allosteric Modulators of Factor XIa by Targeting Hydrophobic Domains Adjacent to Its Heparin-Binding Site

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2415-2428

2013

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Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine β‑Lactamases by Relieving Steric Strain

Biochemistry (Easton), 2016-05, Vol.55 (17), p.2479-2490

2016

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Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations

Scientific reports, 2016-09, Vol.6 (1), p.33195-33195, Article 33195

2016

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Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

mAbs, 2022, Vol.14 (1), p.2135183

2022

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Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25393-25403

2014

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Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability: e1004949

PLoS pathogens, 2015-06, Vol.11 (6)

2015

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Avoiding the Carbapenem Trap: KPC‐2 β‐lactamase Sequence Requirements for Carbapenem Hydrolysis

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate

The Journal of biological chemistry, 2020-12, Vol.296, p.100155

2020

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Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-[beta]-Lactamase is Fragile to Mutations

Scientific reports, 2016-09, Vol.6, p.33195

2016

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Industry Standards from Accellera

21st International Conference on VLSI Design (VLSID 2008), 2008, p.728-728

Mehta, S.

2008

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Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

mAbs, 2022, Vol.14 (1)

2022

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Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

mAbs, 2022, Vol.14 (1)

2022

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Industry perspective on chip multi-threading, bridging the gap with academia using OpenSPARC

Proceedings of the 2007 workshop on Computer architecture education, 2007, p.65-65

2007

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Is methodology the highway out of verification hell?

Annual ACM IEEE Design Automation Conference: Proceedings of the 42nd annual conference on Design automation, 2005, p.521-522

2005

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Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies

PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates

KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate

A Mechanistic Understanding of Monoclonal Antibody Interfacial Protection by Hydrolytically Degraded Polysorbate 20 and 80 under IV Bag Conditions

Protein conjugates and fusion proteins as ocular therapeutics

Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 β-lactamase

Lead Optimization Yields High Affinity Frizzled 7‑Targeting Peptides That Modulate Clostridium difficile Toxin B Pathogenicity in Epithelial Cells

β-Lactams Increase the Antibacterial Activity of Daptomycin against Clinical Methicillin-Resistant Staphylococcus aureus Strains and Prevent Selection of Daptomycin-Resistant Derivatives

VraSR Two-Component Regulatory System Contributes to mprF-Mediated Decreased Susceptibility to Daptomycin in In Vivo-Selected Clinical Strains of Methicillin-Resistant Staphylococcus aureus

Discovery of Allosteric Modulators of Factor XIa by Targeting Hydrophobic Domains Adjacent to Its Heparin-Binding Site

Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine β‑Lactamases by Relieving Steric Strain

Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations

Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability: e1004949

Avoiding the Carbapenem Trap: KPC‐2 β‐lactamase Sequence Requirements for Carbapenem Hydrolysis

KPC-2 β-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate

Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-[beta]-Lactamase is Fragile to Mutations

Industry Standards from Accellera

Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms

Industry perspective on chip multi-threading, bridging the gap with academia using OpenSPARC

Is methodology the highway out of verification hell?

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