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430 Design and structure–activity relationships of highly potent and bioavailable imidazolinone FASN KR domain inhibitors

European journal of cancer (1990), 2014-11, Vol.50, p.141-142

2014

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400 Optimization of novel pyrido[2,3-b]pyrazine based small molecule fibroblast growth factor receptor 1, 2, 3 & 4 (FGFR) inhibitors into a potential clinical candidate

European journal of cancer (1990), 2014-11, Vol.50, p.128-128

2014

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356 Discovery of novel pyrido[2,3-b]pyrazine as fibroblast growth factor receptor (FGFR-1, 2, 3 & 4) kinase inhibitors with nanomolar affinity

European journal of cancer (1990), 2014-11, Vol.50, p.115-115

2014

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In Vitro and In Vivo Activities of the Novel Azole Antifungal Agent R126638

Antimicrobial Agents and Chemotherapy, 2004-02, Vol.48 (2), p.388-391

2004

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Liquid chromatography–mass spectrometry with chemiluminescent nitrogen detection for on-line quantitative analysis of compound collections: advantages and limitations

Journal of Chromatography A, 2004-11, Vol.1056 (1), p.67-75

2004

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The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

Antimicrobial Agents and Chemotherapy, 2004-09, Vol.48 (9), p.3272-3278

2004

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Outsourcing to exploit a key asset

Drug discovery today, 2006-06, Vol.11 (11), p.556-560

2006

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Synthesis of 3,5-dihalogeno-2H-1,4-oxazin-2-ones from cyanohydrines

Tetrahedron letters, 1989, Vol.30 (24), p.3183-3186

1989

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Pyrrolo[1,2- a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3453-3458

2005

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Liquid chromatography-mass spectrometry with chemiluminescent nitrogen detection for on-line quantitative analysis of compound collections: advantages and limitations

Journal of Chromatography A, 2004-11, Vol.1056 (1-2), p.67-75

2004

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Cycloaddition of Olefinic Compounds to 2H-1,4-Oxazin-2-ones: Synthesis of 2-Oxa-5-azabicyclo[2.2.2]oct-5-en-3-ones

Synthesis (Stuttgart), 1992, Vol.1992 (7), p.705-709

1992

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C-Glycosides and C-disaccharide precursors through carbonylative Stille coupling reactions

Tetrahedron letters, 1997-01, Vol.38 (4), p.543-546

1997

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Synthesis and in Vitro and in Vivo Structure−Activity Relationships of Novel Antifungal Triazoles for Dermatology

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.2184-2193

2005

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Diels-Alder Reactions of 6-Alkyl-3,5-dichloro-2H-1,4-oxazin-2-ones with Alkynes: Synthesis of 3,5-Disubstituted 2,6-Dichloropyridines

Synthesis (Stuttgart), 1991, Vol.1991 (9), p.765-768

1991

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In vitro and in vivo activities of the novel azole antifungal agent R126638

Antimicrobial agents and chemotherapy, 2004, Vol.48 (4), p.388-391

2004

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Synthesis and Anti-Angiogenic Activity of 6-(1,2,4-Thiadiazol-5-yl)-3-amino pyridazine Derivatives

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (4), p.589-591

2002

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A General Synthesis of 3,5-Dihalo-2H-1,4-oxazin-2-ones from Cyanohydrins

Synthesis (Stuttgart), 1990, Vol.1990 (10), p.905-908

1990

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Cycloaddition of 3-Amino-5-chloro-2(1H)-pyrazinones and Olefins: Ring Transformation into 3-Amino- or 6-Cyano-Substituted 2-Pyridinone Systems

Journal of organic chemistry, 1996-01, Vol.61 (1), p.304-308

1996

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The synthesis of 3-functionalized 5-chloro-6-methyl-2H-1,4-oxazin-2-ones and of pyridines from cycloaddition-elimination reactions with substituted acetylenic compounds

Tetrahedron, 1994-04, Vol.50 (17), p.5211-5224

1994

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Synthesis of 6-methoxy- and 6-chloro-2(1H)-pyridinone acyclo-C-nucleosides from 2H-1,4-oxazin-2-ones

Tetrahedron, 1993-05, Vol.49 (19), p.4085-4098

1993

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Hypolipidemic effects of R103757, a potent stereoselective inhibitor of microsomal triglyceride transfer protein (MTP)

Atherosclerosis, 1999-05, Vol.144, p.38-38

1999

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Functionalisation in position 3 of 3,5-dichloro-2H-1,4-oxazin-2-ones

Tetrahedron letters, 1992-05, Vol.33 (19), p.2713-2716

1992

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Homochiral matching in the Diels-Alder cyclodimerization of 2-vinyl-7-oxabicyclo[2.2.1]hept-2-ene derivatives

Tetrahedron letters, 1994, Vol.35 (1), p.111-114

1994

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Cycloaddition of Olefinic Compounds to 2 H -1,4-Oxazin-2-ones: Synthesis of 2-Oxa-5-azabicyclo[2.2.2]oct-5-en-3-ones

Synthesis (Stuttgart), 1992, Vol.1992 (7), p.705-709

1992

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An approach to acyclo-1-deazathymidine C-nucleosides via 3,5-dichloro-6-methyl-2H-1,4-oxazin 2-one

Tetrahedron, 1991, Vol.47 (48), p.10065-10076

1991

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430 Design and structure–activity relationships of highly potent and bioavailable imidazolinone FASN KR domain inhibitors

400 Optimization of novel pyrido[2,3-b]pyrazine based small molecule fibroblast growth factor receptor 1, 2, 3 & 4 (FGFR) inhibitors into a potential clinical candidate

356 Discovery of novel pyrido[2,3-b]pyrazine as fibroblast growth factor receptor (FGFR-1, 2, 3 & 4) kinase inhibitors with nanomolar affinity

In Vitro and In Vivo Activities of the Novel Azole Antifungal Agent R126638

Liquid chromatography–mass spectrometry with chemiluminescent nitrogen detection for on-line quantitative analysis of compound collections: advantages and limitations

The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

Outsourcing to exploit a key asset

Synthesis of 3,5-dihalogeno-2H-1,4-oxazin-2-ones from cyanohydrines

Pyrrolo[1,2- a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents

Liquid chromatography-mass spectrometry with chemiluminescent nitrogen detection for on-line quantitative analysis of compound collections: advantages and limitations

Cycloaddition of Olefinic Compounds to 2H-1,4-Oxazin-2-ones: Synthesis of 2-Oxa-5-azabicyclo[2.2.2]oct-5-en-3-ones

C-Glycosides and C-disaccharide precursors through carbonylative Stille coupling reactions

Synthesis and in Vitro and in Vivo Structure−Activity Relationships of Novel Antifungal Triazoles for Dermatology

Diels-Alder Reactions of 6-Alkyl-3,5-dichloro-2H-1,4-oxazin-2-ones with Alkynes: Synthesis of 3,5-Disubstituted 2,6-Dichloropyridines

In vitro and in vivo activities of the novel azole antifungal agent R126638

Synthesis and Anti-Angiogenic Activity of 6-(1,2,4-Thiadiazol-5-yl)-3-amino pyridazine Derivatives

A General Synthesis of 3,5-Dihalo-2H-1,4-oxazin-2-ones from Cyanohydrins

Cycloaddition of 3-Amino-5-chloro-2(1H)-pyrazinones and Olefins: Ring Transformation into 3-Amino- or 6-Cyano-Substituted 2-Pyridinone Systems

The synthesis of 3-functionalized 5-chloro-6-methyl-2H-1,4-oxazin-2-ones and of pyridines from cycloaddition-elimination reactions with substituted acetylenic compounds

Synthesis of 6-methoxy- and 6-chloro-2(1H)-pyridinone acyclo-C-nucleosides from 2H-1,4-oxazin-2-ones

Hypolipidemic effects of R103757, a potent stereoselective inhibitor of microsomal triglyceride transfer protein (MTP)

Functionalisation in position 3 of 3,5-dichloro-2H-1,4-oxazin-2-ones

Homochiral matching in the Diels-Alder cyclodimerization of 2-vinyl-7-oxabicyclo[2.2.1]hept-2-ene derivatives

Cycloaddition of Olefinic Compounds to 2 H -1,4-Oxazin-2-ones: Synthesis of 2-Oxa-5-azabicyclo[2.2.2]oct-5-en-3-ones

An approach to acyclo-1-deazathymidine C-nucleosides via 3,5-dichloro-6-methyl-2H-1,4-oxazin 2-one

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