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Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

Journal of applied toxicology, 2014-06, Vol.34 (6), p.595-606

2014

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IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

Critical reviews in toxicology, 2008-01, Vol.38 (2), p.87-96

2008

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How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Toxicological sciences, 2017-02, Vol.155 (2), p.326-336

2017

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The need for good practice in the application of mechanistic constructs in hazard and risk assessment

Toxicological sciences, 2023-06, Vol.194 (1), p.13-22

2023

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IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans

Critical reviews in toxicology, 2006-11, Vol.36 (10), p.781-792

2006

Volltextzugriff (PDF)

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

Journal of applied toxicology, 2014-01, Vol.34 (1), p.1-18

2014

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Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

Critical reviews in toxicology, 2024-02, Vol.54 (2), p.134-151

2024

Volltextzugriff (PDF)

Adverse Outcome Pathways-Organizing Toxicological Information to Improve Decision Making

The Journal of pharmacology and experimental therapeutics, 2016-01, Vol.356 (1), p.170

2016

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Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

Neurotoxicology (Park Forest South), 2017-03, Vol.59, p.240-255

2017

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Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

Critical reviews in toxicology, 2017-10, Vol.47 (9), p.733-753

2017

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A user-friendly tool to assess combined exposures to indoor air pollutants in public spaces of children

Food and chemical toxicology, 2022-07, Vol.165, p.113141, Article 113141

2022

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A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

Critical reviews in toxicology, 2003-01, Vol.33 (6), p.591-653

2003

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Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

Environmental and molecular mutagenesis, 2015-12, Vol.56 (9), p.724-750

2015

Volltextzugriff (PDF)

4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans

Critical reviews in toxicology, 2006-11, Vol.36 (10), p.803-819

2006

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Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

Toxicology (Amsterdam), 2015-06, Vol.332, p.112-123

2015

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Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

Pharmacology & therapeutics (Oxford), 2017-11, Vol.179, p.84-95

2017

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Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Critical reviews in toxicology, 2011-03, Vol.41 (3), p.175-186

2011

Volltextzugriff (PDF)

Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals

Journal of applied toxicology, 2016-09, Vol.36 (9), p.1077-1089

2016

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Overview: Using Mode of Action and Life Stage Information to Evaluate the Human Relevance of Animal Toxicity Data

Critical reviews in toxicology, 2005-10, Vol.35 (8-9), p.663-672

2005

Volltextzugriff (PDF)

Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity

Journal of applied toxicology, 2014-11, Vol.34 (11), p.1115-1121

2014

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Is peer review an appropriate form of assessment in a MOOC? Student participation and performance in formative peer review

Assessment and evaluation in higher education, 2017-08, Vol.42 (6), p.1000-1013

2017

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Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Regulatory toxicology and pharmacology, 2013-06, Vol.66 (1), p.116-129

2013

Volltextzugriff (PDF)

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

Chemico-biological interactions, 2010-03, Vol.184 (1), p.279-285

2010

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The Human Relevance of Information on Carcinogenic Modes of Action: Overview

Critical reviews in toxicology, 2003-01, Vol.33 (6), p.581-589

2003

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A framework for fit-for-purpose dose response assessment

Regulatory toxicology and pharmacology, 2013-07, Vol.66 (2), p.234-240

2013

Volltextzugriff (PDF)

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Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

The need for good practice in the application of mechanistic constructs in hazard and risk assessment

IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

Adverse Outcome Pathways-Organizing Toxicological Information to Improve Decision Making

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

A user-friendly tool to assess combined exposures to indoor air pollutants in public spaces of children

A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans

Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals

Overview: Using Mode of Action and Life Stage Information to Evaluate the Human Relevance of Animal Toxicity Data

Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity

Is peer review an appropriate form of assessment in a MOOC? Student participation and performance in formative peer review

Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

The Human Relevance of Information on Carcinogenic Modes of Action: Overview

A framework for fit-for-purpose dose response assessment

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