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Multi-targeting drugs: past, present and future

Orvosi hetilap, 2020-04, Vol.161 (14), p.523

Mátyus, Péter

2020

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Isoneocryptolepine, a Synthetic Indoloquinoline Alkaloid, as an Antiplasmodial Lead Compound

Journal of natural products (Washington, D.C.), 2005-05, Vol.68 (5), p.674-677

2005

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Mechanisms of glycine release, which build up synaptic and extrasynaptic glycine levels: The role of synaptic and non-synaptic glycine transporters

Brain research bulletin, 2013-04, Vol.93, p.110-119

2013

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Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats

Brain research, 2006-10, Vol.1116 (1), p.159-165

2006

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Remarkable regioselectivities in the course of the synthesis of two new Luotonin A derivatives

Tetrahedron, 2017-06, Vol.73 (23), p.3231-3239

2017

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Effect of liposomal formulation of ascorbic acid on corneal permeability

Scientific reports, 2023-03, Vol.13 (1), p.3448-3448, Article 3448

2023

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Effects of Chemical Structures Interacting with Amine Oxidases on Glucose, Lipid and Hydrogen Peroxide Handling by Human Adipocytes

Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6224

2022

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C(sp 3 )-H cyclizations of 2-(2-vinyl)phenoxy- tert -anilines

RSC advances, 2024-05, Vol.14 (24), p.16784-16800

2024

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Synthesis of novel fused azecine ring systems through application of the tert-amino effect

Tetrahedron, 2010-03, Vol.66 (13), p.2331-2339

2010

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Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

Molecules (Basel, Switzerland), 2021-06, Vol.26 (13), p.3821

2021

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Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development

ChemMedChem, 2016-06, Vol.11 (12), p.1197-1198

2016

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Novel Arylalkenylpropargylamines as Neuroprotective, Potent, and Selective Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s Disease

Journal of medicinal chemistry, 2015-02, Vol.58 (3), p.1400-1419

2015

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Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis

Expert opinion on investigational drugs, 2012-09, Vol.21 (9), p.1267-1308

2012

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alpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actions

Neurochemistry international, 2009-12, Vol.55 (7), p.447-453

2009

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Analysis of the role of central and peripheral α2-adrenoceptor subtypes in gastric mucosal defense in the rat

Neurochemistry international, 2007-10, Vol.51 (5), p.289-296

2007

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Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats

Biomedicine & pharmacotherapy, 2021-02, Vol.134, p.111105, Article 111105

2021

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Structure–activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues

Bioorganic & medicinal chemistry, 2009-10, Vol.17 (20), p.7209-7217

2009

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Analysis of Edg-Like LPA Receptor-Ligand Interactions

Current pharmaceutical design, 2015-01, Vol.21 (24), p.3533

2015

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[1,5]-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1265

2020

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The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases

Journal of enzyme inhibition and medicinal chemistry, 2016-11, Vol.31 (sup3), p.194-204

2016

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Drug repositioning for treatment of movement disorders: from serendipity to rational discovery strategies

Current topics in medicinal chemistry, 2013-09, Vol.13 (18), p.2337

2013

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Interaction of SZV 1287, a novel oxime analgesic drug candidate, and its metabolites with serum albumin

Journal of molecular liquids, 2021-07, Vol.333, p.115945, Article 115945

2021

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Analgesic effects of the novel semicarbazide-sensitive amine oxidase inhibitor SZV 1287 in mouse pain models with neuropathic mechanisms: Involvement of transient receptor potential vanilloid 1 and ankyrin 1 receptors

Pharmacological research, 2018-05, Vol.131, p.231-243

2018

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Ring-Closure Reactions of ortho-Vinyl-tert-anilines and (Di)Aza-Heterocyclic Analogues via the tert-Amino Effect: Recent Developments

Synthesis (Stuttgart), 2006-08, Vol.2006 (16), p.2625-2639

2006

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Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease

Molecular neurodegeneration, 2016-01, Vol.11 (6), p.6, Article 6

2016

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Multi-targeting drugs: past, present and future

Isoneocryptolepine, a Synthetic Indoloquinoline Alkaloid, as an Antiplasmodial Lead Compound

Mechanisms of glycine release, which build up synaptic and extrasynaptic glycine levels: The role of synaptic and non-synaptic glycine transporters

Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats

Remarkable regioselectivities in the course of the synthesis of two new Luotonin A derivatives

Effect of liposomal formulation of ascorbic acid on corneal permeability

Effects of Chemical Structures Interacting with Amine Oxidases on Glucose, Lipid and Hydrogen Peroxide Handling by Human Adipocytes

C(sp 3 )-H cyclizations of 2-(2-vinyl)phenoxy- tert -anilines

Synthesis of novel fused azecine ring systems through application of the tert-amino effect

Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions

Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development

Novel Arylalkenylpropargylamines as Neuroprotective, Potent, and Selective Monoamine Oxidase B Inhibitors for the Treatment of Parkinson’s Disease

Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis

alpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actions

Analysis of the role of central and peripheral α2-adrenoceptor subtypes in gastric mucosal defense in the rat

Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats

Structure–activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues

Analysis of Edg-Like LPA Receptor-Ligand Interactions

[1,5]-Hydride Shift-Cyclization versus C(sp 2 )-H Functionalization in the Knoevenagel-Cyclization Domino Reactions of 1,4- and 1,5-Benzoxazepines

The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases

Drug repositioning for treatment of movement disorders: from serendipity to rational discovery strategies

Interaction of SZV 1287, a novel oxime analgesic drug candidate, and its metabolites with serum albumin

Analgesic effects of the novel semicarbazide-sensitive amine oxidase inhibitor SZV 1287 in mouse pain models with neuropathic mechanisms: Involvement of transient receptor potential vanilloid 1 and ankyrin 1 receptors

Ring-Closure Reactions of ortho-Vinyl-tert-anilines and (Di)Aza-Heterocyclic Analogues via the tert-Amino Effect: Recent Developments

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease

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