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Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities

Diabetes (New York, N.Y.), 1998-03, Vol.47 (3), p.307-315

1998

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Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation

The New England journal of medicine, 1998-01, Vol.338 (4), p.226-230

1998

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Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

Diabetes (New York, N.Y.), 1990-06, Vol.39 (6), p.647-652

Matschinsky, F. M.

1990

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Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

Genes & development, 2001-07, Vol.15 (13), p.1706-1715

2001

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High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI

Diabetologia, 2001-07, Vol.44 (7), p.898-905

2001

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Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

Diabetologia, 1999-10, Vol.42 (10), p.1175-1186

1999

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Glucokinase and glucose homeostasis: proven concepts and new ideas

Biochemical Society transactions, 2005-02, Vol.33 (Pt 1), p.306-310

2005

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A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

Diabetes (New York, N.Y.), 1996-02, Vol.45 (2), p.223-241

Matschinsky, Franz M

1996

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Glucose regulation of glutaminolysis and its role in insulin secretion

Diabetes (New York, N.Y.), 1999-08, Vol.48 (8), p.1535-1542

1999

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Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut

The Journal of biological chemistry, 1994-02, Vol.269 (5), p.3641-3654

1994

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Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia

Diabetes (New York, N.Y.), 1999-09, Vol.48 (9), p.1698-1705

1999

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Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9)

Diabetologia, 1997-09, Vol.40 (9), p.1018-1027

1997

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Insulin gene transfer enhances the function of human islet grafts

Diabetologia, 2003-03, Vol.46 (3), p.386-393

2003

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Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea

Biochimica et biophysica acta. Proteins and proteomics, 2012-05, Vol.1824 (5), p.769-784

2012

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Neonatal Diabetes Mellitus Due to Complete Glucokinase Deficiency

The New England journal of medicine, 2001-05, Vol.344 (21), p.1588-1592

2001

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A Role for Malonyl-CoA in Glucose-Stimulated Insulin Secretion from Clonal Pancreatic β-Cells

The Journal of biological chemistry, 1989-12, Vol.264 (36), p.21608-21612

1989

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A Signaling Role of Glutamine in Insulin Secretion

The Journal of biological chemistry, 2004-04, Vol.279 (14), p.13393-13401

2004

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Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets

American journal of physiology: endocrinology and metabolism, 1996-09, Vol.271 (3), p.E606-E625

1996

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Glucose regulates glucokinase activity in cultured islets from rat pancreas

The Journal of biological chemistry, 1990-10, Vol.265 (28), p.16863-16866

1990

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The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas

The Journal of biological chemistry, 1991-12, Vol.266 (34), p.22887-22892

1991

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Glucose metabolism and insulin release in mouse beta HC9 cells, as model for wild-type pancreatic beta-cells

American journal of physiology: endocrinology and metabolism, 1996-05, Vol.270 (5), p.E846-E857

1996

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Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

Diabetes (New York, N.Y.), 1990-06, Vol.39 (6), p.647-652

Matschinsky, F M

1990

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Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture

Diabetes (New York, N.Y.), 1992-07, Vol.41 (7), p.792-806

1992

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Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets

The Journal of biological chemistry, 1992-08, Vol.267 (24), p.17241-17247

1992

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Are there kinetic advantages of GLUT2 in pancreatic glucose sensing?

Diabetologia, 1997-01, Vol.40 (1), p.112-119

1997

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Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities

Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation

Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

High prevalence of glucokinase mutations in Italian children with MODY. Influence on glucose tolerance, first-phase insulin response, insulin sensitivity and BMI

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

Glucokinase and glucose homeostasis: proven concepts and new ideas

A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

Glucose regulation of glutaminolysis and its role in insulin secretion

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia

Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9)

Insulin gene transfer enhances the function of human islet grafts

Thermal stabilty of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea

Neonatal Diabetes Mellitus Due to Complete Glucokinase Deficiency

A Role for Malonyl-CoA in Glucose-Stimulated Insulin Secretion from Clonal Pancreatic β-Cells

A Signaling Role of Glutamine in Insulin Secretion

Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets

Glucose regulates glucokinase activity in cultured islets from rat pancreas

The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas

Glucose metabolism and insulin release in mouse beta HC9 cells, as model for wild-type pancreatic beta-cells

Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes

Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture

Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets

Are there kinetic advantages of GLUT2 in pancreatic glucose sensing?

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