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Adhesion GPCRs as a paradigm for understanding polycystin-1 G protein regulation

Cellular signalling, 2020-08, Vol.72, p.109637-109637, Article 109637

2020

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Mechanism of tethered agonist-mediated signaling by polycystin-1

Proceedings of the National Academy of Sciences - PNAS, 2022-05, Vol.119 (19), p.e2113786119-e2113786119

2022

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Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

eLife, 2024-10, Vol.13

2024

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Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

Scientific reports, 2018-02, Vol.8 (1), p.3340-12, Article 3340

2018

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The GPCR properties of polycystin-1- A new paradigm

Frontiers in molecular biosciences, 2022-11, Vol.9, p.1035507-1035507

2022

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Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

Molecular and cellular biology, 2014-09, Vol.34 (17), p.3341-3353

2014

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Intraflagellar Transport Proteins as Regulators of Primary Cilia Length

Frontiers in cell and developmental biology, 2021-05, Vol.9, p.661350-661350

2021

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A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD

Human molecular genetics, 2018-10, Vol.27 (19), p.3313-3324

2018

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Tubular Obstruction Leads to Progressive Proximal Tubular Injury and Atubular Glomeruli in Polycystic Kidney Disease

The American journal of pathology, 2014-07, Vol.184 (7), p.1957-1966

2014

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Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression

The Journal of biological chemistry, 2006-10, Vol.281 (41), p.30884-30895

2006

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Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/ Na+,K+,2Cl- Co-transporter-dependent cystic dilation

Journal of the American Society of Nephrology, 2006-12, Vol.17 (12), p.3424-3437

2006

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Transmembrane Domain Analysis of Polycystin-1, the Product of the Polycystic Kidney Disease-1 (PKD1) Gene: Evidence for 11 Membrane-Spanning Domains

Biochemistry (Easton), 2003-11, Vol.42 (44), p.13035-13048

2003

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Primary Cilia in Cystic Kidney Disease

Kidney Development and Disease, 2017, Vol.60, p.281-321

2017

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In Vivo Analysis of Polycystin-1: Heterotrimeric G-protein Binding by NanoBiT: FR-PO585

Journal of the American Society of Nephrology, 2024-10, Vol.35 (10S)

2024

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Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins

The Journal of biological chemistry, 2002-05, Vol.277 (22), p.19566-19572

2002

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Metanephric organ culture

Methods in Kidney Cell Biology Part A, 2019, Vol.153, p.169-183

2019

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Polycystin-1 Activates the Calcineurin/NFAT (Nuclear Factor of Activated T-cells) Signaling Pathway

The Journal of biological chemistry, 2004-12, Vol.279 (53), p.55455-55464

2004

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Overexpression of the Polycystin-1 C-Tail Enhances Sensitivity of M-1 Cells to Ouabain

The Journal of membrane biology, 2013-07, Vol.246 (7), p.581-590

2013

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MAP/ERK Kinase Kinase 1 (MEKK1) Mediates Transcriptional Repression by Interacting with Polycystic Kidney Disease-1 (PKD1) Promoter-bound p53 Tumor Suppressor Protein

The Journal of biological chemistry, 2010-12, Vol.285 (50), p.38818-38831

2010

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Effect of PKD1 Gene Missense Mutations on Polycystin-1 Membrane Topogenesis

Biochemistry (Easton), 2011-01, Vol.50 (3), p.349-355

2011

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Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1

American Journal of Physiology - Renal Physiology, 2008-12, Vol.295 (6), p.F1725-F1734

2008

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Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease

Journal of the American Society of Nephrology, 2002-04, Vol.13 (4), p.991-999

2002

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Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

Kidney international, 2003-02, Vol.63 (2), p.427-437

2003

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Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter

American Journal of Physiology - Renal Physiology, 2008-12, Vol.295 (6), p.F1845-F1854

2008

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ADPKD Mutations in the Stalk/Tethered Agonist of Polycystin-1 CTF Affect Signaling and GPS Cleavage: PO1217

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.395-395

2021

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Adhesion GPCRs as a paradigm for understanding polycystin-1 G protein regulation

Mechanism of tethered agonist-mediated signaling by polycystin-1

Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

The GPCR properties of polycystin-1- A new paradigm

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

Intraflagellar Transport Proteins as Regulators of Primary Cilia Length

A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD

Tubular Obstruction Leads to Progressive Proximal Tubular Injury and Atubular Glomeruli in Polycystic Kidney Disease

Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression

Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/ Na+,K+,2Cl- Co-transporter-dependent cystic dilation

Transmembrane Domain Analysis of Polycystin-1, the Product of the Polycystic Kidney Disease-1 (PKD1) Gene: Evidence for 11 Membrane-Spanning Domains

Primary Cilia in Cystic Kidney Disease

In Vivo Analysis of Polycystin-1: Heterotrimeric G-protein Binding by NanoBiT: FR-PO585

Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins

Metanephric organ culture

Polycystin-1 Activates the Calcineurin/NFAT (Nuclear Factor of Activated T-cells) Signaling Pathway

Overexpression of the Polycystin-1 C-Tail Enhances Sensitivity of M-1 Cells to Ouabain

MAP/ERK Kinase Kinase 1 (MEKK1) Mediates Transcriptional Repression by Interacting with Polycystic Kidney Disease-1 (PKD1) Promoter-bound p53 Tumor Suppressor Protein

Effect of PKD1 Gene Missense Mutations on Polycystin-1 Membrane Topogenesis

Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1

Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease

Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter

ADPKD Mutations in the Stalk/Tethered Agonist of Polycystin-1 CTF Affect Signaling and GPS Cleavage: PO1217

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