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Androgen receptor defects : historical, clinical, and molecular perspectives

Endocrine reviews, 1995-06, Vol.16 (3), p.271-321

1995

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Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2683-2696

2003

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Discovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071)

Journal of medicinal chemistry, 1999-01, Vol.42 (2), p.210-212

1999

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Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2- g]quinolinone

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (7), p.1009-1012

1999

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5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.291-302

1998

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5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists: The Effect of D-Ring Substituents

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.303-310

1998

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New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1 H)-pyrrolidino[3,2- g]quinolinone

Bioorganic & medicinal chemistry letters, 1998-04, Vol.8 (7), p.745-750

1998

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Response elements of the androgen-regulated C3 gene

The Journal of biological chemistry, 1992-03, Vol.267 (7), p.4456-4466

1992

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Receptor accessory factor enhances specific DNA binding of androgen and glucocorticoid receptors

The Journal of biological chemistry, 1993-08, Vol.268 (23), p.17519-17527

1993

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Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (5), p.415-418

2000

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Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3461-3466

1998

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5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a Novel Class of Nonsteroidal Progesterone Receptor Agonists: Effect of A-Ring Modification

Journal of medicinal chemistry, 1999-04, Vol.42 (8), p.1466-1472

1999

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4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6- g]quinolines: Potent, nonsteroidal androgen receptor agonists

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (9), p.1335-1340

1999

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Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (7), p.1003-1008

1999

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Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.623-639

1998

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A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity

The Journal of biological chemistry, 1993-12, Vol.268 (36), p.27226-27235

1993

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5-Benzylidene 1,2-Dihydrochromeno[3,4-f]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4354-4359

1998

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Characterization of mutant androgen receptors causing partial androgen insensitivity syndrome

The journal of clinical endocrinology and metabolism, 1994-03, Vol.78 (3), p.513-522

1994

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Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2731-2736

1998

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Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones

Bioorganic & medicinal chemistry letters, 2001-10, Vol.11 (20), p.2747-2750

2001

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Androgen receptor-mediated antagonism of estrogen-dependent low density lipoprotein receptor transcription in cultured hepatocytes

Endocrinology (Philadelphia), 1997-09, Vol.138 (9), p.3779-3786

1997

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Characterization of a hepatic protein in nonhuman primates that binds mibolerone but not dihydrotestosterone or methyltrienolone

Steroids, 1995-11, Vol.60 (11), p.759-767

1995

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Estrogen and estrogen receptor antagonists stimulate transcription from the human retinoic acid receptor-alpha 1 promoter via a novel sequence

Molecular endocrinology (Baltimore, Md.), 1996-05, Vol.10 (5), p.477-487

1996

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Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7H-[1,4]Oxazino[3,2-g]quinolin-7-ones

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2486-2496

2007

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Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6- g]quinolines

Bioorganic & medicinal chemistry letters, 2000-03, Vol.10 (5), p.411-414

2000

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Androgen receptor defects : historical, clinical, and molecular perspectives

Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

Discovery of a Potent, Orally Active, Nonsteroidal Androgen Receptor Agonist: 4-Ethyl-1,2,3,4-tetrahydro-6- (trifluoromethyl)-8-pyridono[5,6-g]- quinoline (LG121071)

Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2- g]quinolinone

5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as Potent, Orally Active, Nonsteroidal Progesterone Receptor Agonists: The Effect of D-Ring Substituents

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1 H)-pyrrolidino[3,2- g]quinolinone

Response elements of the androgen-regulated C3 gene

Receptor accessory factor enhances specific DNA binding of androgen and glucocorticoid receptors

Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines

Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore

5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a Novel Class of Nonsteroidal Progesterone Receptor Agonists: Effect of A-Ring Modification

4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6- g]quinolines: Potent, nonsteroidal androgen receptor agonists

Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one

Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines

A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity

5-Benzylidene 1,2-Dihydrochromeno[3,4-f]quinolines, A Novel Class of Nonsteroidal Human Progesterone Receptor Agonists

Characterization of mutant androgen receptors causing partial androgen insensitivity syndrome

Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones

Androgen receptor-mediated antagonism of estrogen-dependent low density lipoprotein receptor transcription in cultured hepatocytes

Characterization of a hepatic protein in nonhuman primates that binds mibolerone but not dihydrotestosterone or methyltrienolone

Estrogen and estrogen receptor antagonists stimulate transcription from the human retinoic acid receptor-alpha 1 promoter via a novel sequence

Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7H-[1,4]Oxazino[3,2-g]quinolin-7-ones

Effects of isosteric pyridone replacements in androgen receptor antagonists based on 1,2-dihydro- and 1,2,3,4-tetrahydro-2,2-dimethyl-6-trifluoromethyl-8-pyridono[5,6- g]quinolines

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