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Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease

Journal of the American Society of Nephrology, 2016-04, Vol.27 (4), p.1124-1134

2016

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Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression

The Journal of biological chemistry, 2006-10, Vol.281 (41), p.30884-30895

2006

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Calcium Restriction Allows cAMP Activation of the B-Raf/ERK Pathway, Switching Cells to a cAMP-dependent Growth-stimulated Phenotype

The Journal of biological chemistry, 2004-09, Vol.279 (39), p.40419-40430

2004

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Polycystin-1 Regulates Skeletogenesis through Stimulation of the Osteoblast-specific Transcription Factor RUNX2-II

The Journal of biological chemistry, 2008-05, Vol.283 (18), p.12624-12634

2008

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Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

American journal of physiology. Renal physiology, 2012-10, Vol.303 (7), p.F982-F990

2012

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Mechanism of tethered agonist-mediated signaling by polycystin-1

Proceedings of the National Academy of Sciences - PNAS, 2022-05, Vol.119 (19), p.e2113786119-e2113786119

2022

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Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins

The Journal of biological chemistry, 2002-05, Vol.277 (22), p.19566-19572

2002

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Polycystin-1 Activates the Calcineurin/NFAT (Nuclear Factor of Activated T-cells) Signaling Pathway

The Journal of biological chemistry, 2004-12, Vol.279 (53), p.55455-55464

2004

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A tumor necrosis factor-α-mediated pathway promoting autosomal dominant polycystic kidney disease

Nature medicine, 2008-08, Vol.14 (8), p.863-868

2008

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A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD

Human molecular genetics, 2018-10, Vol.27 (19), p.3313-3324

2018

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Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease

Journal of the American Society of Nephrology, 2002-04, Vol.13 (4), p.991-999

2002

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The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease

American journal of physiology. Renal physiology, 2022-10, Vol.323 (4), p.F492-F506

2022

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Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter

American Journal of Physiology - Renal Physiology, 2008-12, Vol.295 (6), p.F1845-F1854

2008

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Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells

The Journal of membrane biology, 2015-12, Vol.248 (6), p.1145-1157

2015

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Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/ Na+,K+,2Cl- Co-transporter-dependent cystic dilation

Journal of the American Society of Nephrology, 2006-12, Vol.17 (12), p.3424-3437

2006

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Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells

Kidney international, 2001-08, Vol.60 (2), p.484-494

2001

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Metanephric organ culture

Methods in Kidney Cell Biology Part A, 2019, Vol.153, p.169

2019

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Overexpression of the Polycystin-1 C-Tail Enhances Sensitivity of M-1 Cells to Ouabain

The Journal of membrane biology, 2013-07, Vol.246 (7), p.581-590

2013

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MAP/ERK Kinase Kinase 1 (MEKK1) Mediates Transcriptional Repression by Interacting with Polycystic Kidney Disease-1 (PKD1) Promoter-bound p53 Tumor Suppressor Protein

The Journal of biological chemistry, 2010-12, Vol.285 (50), p.38818-38831

2010

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The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression

The Journal of biological chemistry, 2006-10, Vol.281 (42), p.31234-31244

2006

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ADPKD Mutations in the Stalk/Tethered Agonist of Polycystin-1 CTF Affect Signaling and GPS Cleavage: PO1217

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.395-395

2021

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Mechanisms of Tethered-Ligand Mediated Polycystin 1 GPCR Signaling: PO1510

Journal of the American Society of Nephrology, 2020-10, Vol.31 (10S), p.484-484

2020

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Allosteric Mechanism of PC1 Tethered Agonist-Mediated Signaling: PO1239

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.400-401

2021

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Ets factors regulate the polycystic kidney disease-1 promoter

Biochemical and biophysical research communications, 2006-04, Vol.342 (4), p.1005-1013

2006

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The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression

The Journal of biological chemistry, 2006-10, Vol.281 (42), p.31234-31244

2006

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Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease

Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression

Calcium Restriction Allows cAMP Activation of the B-Raf/ERK Pathway, Switching Cells to a cAMP-dependent Growth-stimulated Phenotype

Polycystin-1 Regulates Skeletogenesis through Stimulation of the Osteoblast-specific Transcription Factor RUNX2-II

Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways

Mechanism of tethered agonist-mediated signaling by polycystin-1

Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins

Polycystin-1 Activates the Calcineurin/NFAT (Nuclear Factor of Activated T-cells) Signaling Pathway

A tumor necrosis factor-α-mediated pathway promoting autosomal dominant polycystic kidney disease

A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD

Oxidant stress and reduced antioxidant enzyme protection in polycystic kidney disease

The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease

Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter

Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells

Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/ Na+,K+,2Cl- Co-transporter-dependent cystic dilation

Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells

Metanephric organ culture

Overexpression of the Polycystin-1 C-Tail Enhances Sensitivity of M-1 Cells to Ouabain

MAP/ERK Kinase Kinase 1 (MEKK1) Mediates Transcriptional Repression by Interacting with Polycystic Kidney Disease-1 (PKD1) Promoter-bound p53 Tumor Suppressor Protein

The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression

ADPKD Mutations in the Stalk/Tethered Agonist of Polycystin-1 CTF Affect Signaling and GPS Cleavage: PO1217

Mechanisms of Tethered-Ligand Mediated Polycystin 1 GPCR Signaling: PO1510

Allosteric Mechanism of PC1 Tethered Agonist-Mediated Signaling: PO1239

Ets factors regulate the polycystic kidney disease-1 promoter

The Polycystic Kidney Disease-1 Gene Is a Target for p53-mediated Transcriptional Repression

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