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Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2355-2370

2008

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Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions

Current drug metabolism, 2008-06, Vol.9 (5), p.384-393

2008

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Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2330-2339

2009

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Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs

Drug metabolism and disposition, 2011-07, Vol.39 (7), p.1139-1148

2011

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Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450

Drug metabolism and disposition, 2003-09, Vol.31 (9), p.1161-1169

2003

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Impact of pH on Plasma Protein Binding in Equilibrium Dialysis

Molecular pharmaceutics, 2008-05, Vol.5 (3), p.438-448

2008

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Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes

Drug metabolism and disposition, 2006-10, Vol.34 (10), p.1703-1712

2006

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Structural characterization of novel adenine dinucleotide phosphate conjugates of imatinib in incubations with rat and human liver microsomes

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2414-2418

2008

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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1352-1360

2003

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Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

Drug metabolism and disposition, 2001-04, Vol.29 (4 Pt 1), p.368

2001

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Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.453

2000

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A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4

The Journal of biological chemistry, 2001-01, Vol.276 (3), p.2256-2262

2001

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The role of P-glycoprotein in the bioactivation of raloxifene

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2073-2078

2006

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Antibodies as a probe in cytochrome P450 research

Drug metabolism and disposition, 2009-05, Vol.37 (5), p.925-931

2009

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Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro

Drug metabolism and disposition, 2003-11, Vol.31 (11), p.1300-1305

2003

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Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

Biochemical journal, 1999-06, Vol.340 ( Pt 3) (3), p.845-853

1999

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In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.877

2001

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Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity

Drug metabolism and disposition, 2000-05, Vol.28 (5), p.567

2000

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Selective inhibition of dog hepatic CYP2B11 and CYP3A12

The Journal of pharmacology and experimental therapeutics, 2005-05, Vol.313 (2), p.518-528

2005

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Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine

Drug metabolism and disposition, 2000-09, Vol.28 (9), p.1043

2000

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Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1473

2001

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Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism

The Journal of pharmacology and experimental therapeutics, 1999-12, Vol.291 (3), p.1068

1999

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Enzyme kinetics of cytochrome P450-mediated reactions

Current drug metabolism, 2001-03, Vol.2 (1), p.17-36

2001

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Electrospray Ionization Mass Spectrometric Analysis of Intact Cytochrome P450: Identification of Tienilic Acid Adducts to P450 2C9

Biochemistry (Easton), 1999-02, Vol.38 (8), p.2312-2319

1999

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Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor

Drug metabolism and disposition, 2001-06, Vol.29 (6), p.813

2001

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Modeling, prediction, and in vitro in vivo correlation of CYP3A4 induction

Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions

Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator

Simulation of clinical drug-drug interactions from hepatocyte CYP3A4 induction data and its potential utility in trial designs

Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450

Impact of pH on Plasma Protein Binding in Equilibrium Dialysis

Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes

Structural characterization of novel adenine dinucleotide phosphate conjugates of imatinib in incubations with rat and human liver microsomes

Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor

Substrate inhibition kinetics for cytochrome P450-catalyzed reactions

Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4

The role of P-glycoprotein in the bioactivation of raloxifene

Antibodies as a probe in cytochrome P450 research

Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro

Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin

Substrate-dependent effect of acetonitrile on human liver microsomal cytochrome P450 2C9 (CYP2C9) activity

Selective inhibition of dog hepatic CYP2B11 and CYP3A12

Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine

Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4

Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism

Enzyme kinetics of cytochrome P450-mediated reactions

Electrospray Ionization Mass Spectrometric Analysis of Intact Cytochrome P450: Identification of Tienilic Acid Adducts to P450 2C9

Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor

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