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Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

Advanced drug delivery reviews, 2015-08, Vol.91, p.3-6

Maeda, Hiroshi

2015

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Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

Journal of controlled release, 2012-12, Vol.164 (2), p.138-144

Maeda, Hiroshi

2012

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Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects

Bioconjugate chemistry, 2010-05, Vol.21 (5), p.797-802

Maeda, Hiroshi

2010

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The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery-Personal Remarks and Future Prospects

Journal of personalized medicine, 2021-03, Vol.11 (3), p.229

Maeda, Hiroshi

2021

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The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect

Cancer science, 2013-07, Vol.104 (7), p.779-789

Maeda, Hiroshi

2013

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Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting

Proceedings of the Japan Academy, Series B, 2012/03/09, Vol.88(3), pp.53-71

2012

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Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

Advanced drug delivery reviews, 2020, Vol.157, p.142-160

2020

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The shikimate pathway and aromatic amino Acid biosynthesis in plants

Annual review of plant biology, 2012-01, Vol.63 (1), p.73-105

2012

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Evolutionary Diversification of Primary Metabolism and Its Contribution to Plant Chemical Diversity

Frontiers in plant science, 2019-07, Vol.10, p.881-881

Maeda, Hiroshi A

2019

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Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs

Clinical and translational medicine, 2018-03, Vol.7 (1), p.1-20

2018

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Harnessing evolutionary diversification of primary metabolism for plant synthetic biology

The Journal of biological chemistry, 2019-11, Vol.294 (45), p.16549-16566

Maeda, Hiroshi A.

2019

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The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

Advanced drug delivery reviews, 2013-01, Vol.65 (1), p.71-79

2013

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The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

Advanced drug delivery reviews, 2011-03, Vol.63 (3), p.136-151

2011

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Tyrosine biosynthesis, metabolism, and catabolism in plants

Phytochemistry (Oxford), 2018-05, Vol.149, p.82-102

2018

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A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic Therapy-Problems, Solutions, and Prospects

Microcirculation (New York, N.Y. 1994), 2016-04, Vol.23 (3), p.173-182

2016

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Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: Analogy between angina pectoris and solid tumors and enhancement of the EPR effect

Journal of controlled release, 2010-03, Vol.142 (3), p.296-298

Maeda, Hiroshi

2010

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EPR effect based drug design and clinical outlook for enhanced cancer chemotherapy

Advanced drug delivery reviews, 2011-03, Vol.63 (3), p.129-130

2011

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The entry reaction of the plant shikimate pathway is subjected to highly complex metabolite-mediated regulation

The Plant cell, 2021-05, Vol.33 (3), p.671-696

2021

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Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application

Cancer science, 2009-12, Vol.100 (12), p.2426-2430

2009

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Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls

Expert opinion on drug delivery, 2015-01, Vol.12 (1), p.53-64

2015

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Editorial overview: Plant metabolism without a border: The interface of primary and specialised metabolism

Current opinion in plant biology, 2022-10, Vol.69, p.102296-102296, Article 102296

2022

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Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors

Expert opinion on drug delivery, 2022-02, Vol.19 (2), p.199-212

2022

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Biochemical properties and subcellular localization of tyrosine aminotransferases in Arabidopsis thaliana

Phytochemistry (Oxford), 2016-12, Vol.132, p.16-25

2016

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Evolutionary origin and functional diversification of aminotransferases

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102122-102122, Article 102122

2022

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Fibrinolytic tissue plasminogen activator installed redox-active nanoparticles (t-PA@iRNP) for cancer therapy

Biomaterials, 2020-11, Vol.259, p.120290-120290, Article 120290

2020

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