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The molecular basis for oxidative stress-induced insulin resistance

Antioxidants & redox signaling, 2005-07, Vol.7 (7-8), p.1040-1052

2005

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Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain

PloS one, 2014-09, Vol.9 (9), p.e108693-e108693

2014

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Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Endocrine reviews, 2002-10, Vol.23 (5), p.599-622

2002

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Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

Diabetes (New York, N.Y.), 2003-01, Vol.52 (1), p.1-8

2003

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The Role of Membrane Glycoprotein Plasma Cell Antigen 1/Ectonucleotide Pyrophosphatase Phosphodiesterase 1 in the Pathogenesis of Insulin Resistance and Related Abnormalities

Endocrine reviews, 2008-02, Vol.29 (1), p.62-75

2008

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Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle

PloS one, 2011-05, Vol.6 (5), p.e19878-e19878

2011

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Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid

Diabetes (New York, N.Y.), 2001-02, Vol.50 (2), p.404-410

2001

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Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity

PloS one, 2014-02, Vol.9 (2), p.e88684-e88684

2014

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Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells

Breast cancer research and treatment, 2005-11, Vol.94 (1), p.37-46

2005

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IGF-Binding Protein-1 Levels Are Related to Insulin-Mediated Glucose Disposal and Are a Potential Serum Marker of Insulin Resistance

Diabetes care, 2006-07, Vol.29 (7), p.1535-1537

2006

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Increased Hepatic Levels of the Insulin Receptor Inhibitor, PC-1/NPP1, Induce Insulin Resistance and Glucose Intolerance

Diabetes (New York, N.Y.), 2005-02, Vol.54 (2), p.367-372

2005

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Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells

Journal of cellular biochemistry, 2008-02, Vol.103 (2), p.624-635

2008

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Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth

Molecular cancer therapeutics, 2006-04, Vol.5 (4), p.1079-1086

2006

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Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity

BMC endocrine disorders, 2012-11, Vol.12 (1), p.31-31, Article 31

2012

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Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells

Journal of cellular biochemistry, 2007-12, Vol.102 (6), p.1529-1541

2007

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Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells

The Prostate, 2008-08, Vol.68 (11), p.1232-1240

2008

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Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

Nature genetics, 2005-08, Vol.37 (8), p.863-867

2005

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A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

Diabetes (New York, N.Y.), 2012-05, Vol.61 (5), p.1263-1271

2012

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XOMA 052, an anti‐IL‐1β monoclonal antibody, prevents IL‐1β‐mediated insulin resistance in 3T3‐L1 adipocytes

Obesity (Silver Spring, Md.), 2013-02, Vol.21 (2), p.306-309

2013

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Regulation of Insulin Receptor Function by a Small Molecule Insulin Receptor Activator

The Journal of biological chemistry, 2002-11, Vol.277 (46), p.43565-43571

2002

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Small Molecule Insulin Receptor Activators Potentiate Insulin Action in Insulin-Resistant Cells

Diabetes (New York, N.Y.), 2001-10, Vol.50 (10), p.2323-2328

2001

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Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (6), p.1407-1410

2004

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Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia

American journal of physiology: endocrinology and metabolism, 2006-04, Vol.290 (4), p.E746-E749

2006

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Decreased Insulin Receptor (IR) Autophosphorylation in Fibroblasts from Patients with PCOS: Effects of Serine Kinase Inhibitors and IR Activators

The journal of clinical endocrinology and metabolism, 2002-09, Vol.87 (9), p.4088-4093

2002

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The molecular basis for oxidative stress-induced insulin resistance

Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?

The Role of Membrane Glycoprotein Plasma Cell Antigen 1/Ectonucleotide Pyrophosphatase Phosphodiesterase 1 in the Pathogenesis of Insulin Resistance and Related Abnormalities

Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle

Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid

Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity

Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells

IGF-Binding Protein-1 Levels Are Related to Insulin-Mediated Glucose Disposal and Are a Potential Serum Marker of Insulin Resistance

Increased Hepatic Levels of the Insulin Receptor Inhibitor, PC-1/NPP1, Induce Insulin Resistance and Glucose Intolerance

Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth

Chromium supplementation in non-obese non-diabetic subjects is associated with a decline in insulin sensitivity

Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

XOMA 052, an anti‐IL‐1β monoclonal antibody, prevents IL‐1β‐mediated insulin resistance in 3T3‐L1 adipocytes

Regulation of Insulin Receptor Function by a Small Molecule Insulin Receptor Activator

Small Molecule Insulin Receptor Activators Potentiate Insulin Action in Insulin-Resistant Cells

Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: A potential new approach for the treatment of hyperinsulinemic hypoglycemia

Decreased Insulin Receptor (IR) Autophosphorylation in Fibroblasts from Patients with PCOS: Effects of Serine Kinase Inhibitors and IR Activators

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