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Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses

Neuroscience, 2007-11, Vol.149 (3), p.706-714

2007

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The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets

Neuropharmacology, 2000-03, Vol.39 (4), p.652-663

2000

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Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

Neuropharmacology, 1996, Vol.35 (8), p.1121-1129

1996

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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Nature genetics, 2000-09, Vol.26 (1), p.97-102

2000

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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1234-1241

2000

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N-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A Novel Class of Potent Orally Active Human NK1 Antagonists

Journal of medicinal chemistry, 1996-07, Vol.39 (15), p.2907-2914

1996

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Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Journal of medicinal chemistry, 1998-11, Vol.41 (23), p.4607-4614

1998

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Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

Transgenic research, 2000-04, Vol.9 (2), p.145-154

2000

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An NK1 receptor antagonist affects the circadian regulation of locomotor activity in golden hamsters

Brain research, 1998-07, Vol.800 (1), p.32-39

1998

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L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

Canadian journal of physiology and pharmacology, 1989-05, Vol.67 (5), p.456

1989

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Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator

Anesthesiology (Philadelphia), 2015-11, Vol.123 (5), p.1093-1104

2015

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5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors

Molecular pharmacology, 1991-07, Vol.40 (1), p.22-27

1991

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Identification of a Series of 3-(Benzyloxy)-1-azabicyclo[2.2.2]octane Human NK1 Antagonists

Journal of medicinal chemistry, 1995-11, Vol.38 (24), p.4793-4805

1995

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A Potent, Nonpeptidyl 1H-Quinolone Antagonist for the Gonadotropin-Releasing Hormone Receptor

Journal of medicinal chemistry, 2001-03, Vol.44 (6), p.917-922

2001

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Localisation and stimulation of prostacyclin production in vascular cells

Nature (London), 1978-02, Vol.271 (5645), p.549-551

1978

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Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study

Journal of leukocyte biology, 1993-02, Vol.53 (2), p.117-125

1993

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Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium

Biochemical journal, 1984-05, Vol.219 (3), p.833-842

1984

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Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C

FEBS letters, 1985-09, Vol.188 (2), p.383-388

1985

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Synthesis and Biological Evaluation of NK1 Antagonists Derived from L-Tryptophan

Journal of medicinal chemistry, 1995-03, Vol.38 (6), p.934-941

1995

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Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8

The Journal of experimental medicine, 1993-12, Vol.178 (6), p.1913-1921

1993

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3-Benzyloxy-2-phenylpiperidine NK1 antagonists : The influence of alpha methyl substitution

Bioorganic & medicinal chemistry letters, 1997-12, Vol.7 (23), p.2959-2962

1997

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Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3832-3836

2000

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Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP

Biochemical journal, 1985-11, Vol.232 (1), p.267-271

1985

Volltextzugriff (PDF)

Impaired Neuropathic Pain Responses in Mice Lacking the Chemokine Receptor CCR2

Proceedings of the National Academy of Sciences - PNAS, 2003-06, Vol.100 (13), p.7947-7952

2003

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Melanin-Concentrating Hormone 1 Receptor-Deficient Mice are Lean, Hyperactive, and Hyperphagic and Have Altered Metabolism

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (5), p.3240-3245

2002

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Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses

The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets

Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

N-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines: A Novel Class of Potent Orally Active Human NK1 Antagonists

Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

An NK1 receptor antagonist affects the circadian regulation of locomotor activity in golden hamsters

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator

5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors

Identification of a Series of 3-(Benzyloxy)-1-azabicyclo[2.2.2]octane Human NK1 Antagonists

A Potent, Nonpeptidyl 1H-Quinolone Antagonist for the Gonadotropin-Releasing Hormone Receptor

Localisation and stimulation of prostacyclin production in vascular cells

Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study

Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium

Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C

Synthesis and Biological Evaluation of NK1 Antagonists Derived from L-Tryptophan

Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human RANTES but not human monocyte chemoattractant protein 1, human macrophage inflammatory protein 1 alpha, or human interleukin 8

3-Benzyloxy-2-phenylpiperidine NK1 antagonists : The influence of alpha methyl substitution

Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP

Impaired Neuropathic Pain Responses in Mice Lacking the Chemokine Receptor CCR2

Melanin-Concentrating Hormone 1 Receptor-Deficient Mice are Lean, Hyperactive, and Hyperphagic and Have Altered Metabolism

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