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MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.754

2008

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Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

Cell, 1999-03, Vol.96 (6), p.819-831

1999

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Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3352-3355

2005

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Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5837-5841

2009

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Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6816-6820

2007

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An absolute requirement for Cubitus interruptus in Hedgehog signaling

Development (Cambridge), 2001-03, Vol.128 (5), p.733-742

2001

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Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

Development (Cambridge), 2000-09, Vol.127 (18), p.4001-4010

2000

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Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile

The Journal of biological chemistry, 2004-05, Vol.279 (22), p.23229-23237

2004

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In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

Molecular pharmacology, 2008-06, Vol.73 (6), p.1857-1865

2008

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Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

The Journal of experimental medicine, 2004-01, Vol.199 (2), p.199-207

2004

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Trisubstituted ureas as potent and selective mPGES-1 inhibitors

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1488-1492

2011

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Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.1167-1178

2014

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Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7444-7449

2010

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Inhibition of the Activation of Multiple Serine Proteases with a Cathepsin C Inhibitor Requires Sustained Exposure to Prevent Pro-enzyme Processing

The Journal of biological chemistry, 2007-07, Vol.282 (29), p.20836-20846

2007

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Inhibitors of the inducible microsomal prostaglandin E 2 synthase (mPGES-1) derived from MK-886

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3352-3355

2005

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The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis

Molecular and Cellular Biology, 1993-11, Vol.13 (11), p.6789-6798

1993

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A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3

Molecular and Cellular Biology, 1996-10, Vol.16 (10), p.5328-5334

1996

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Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR

The Journal of biological chemistry, 1999-02, Vol.274 (9), p.5953-5962

1999

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Fourier transform infrared and hydrogen/deuterium exchange reveal an exchange-resistant core of alpha-helical peptide hydrogens in the nicotinic acetylcholine receptor

The Journal of biological chemistry, 1995-12, Vol.270 (49), p.29129-29137

1995

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Structure of the Pore-forming Transmembrane Domain of a Ligand-gated Ion Channel

The Journal of biological chemistry, 2001-06, Vol.276 (26), p.23726-23732

2001

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Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange

Biochemistry (Easton), 1995-11, Vol.34 (46), p.15142-15149

1995

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Secondary Structure Analysis of Individual Transmembrane Segments of the Nicotinic Acetylcholine Receptor by Circular Dichroism and Fourier Transform Infrared Spectroscopy

The Journal of biological chemistry, 1998-01, Vol.273 (2), p.771-777

1998

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The Human Homologue of the Yeast Prt1 Protein Is an Integral Part of the Eukaryotic Initiation Factor 3 Complex and Interacts with p170

The Journal of biological chemistry, 1997-01, Vol.272 (2), p.1110-1116

1997

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Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B have RNA annealing activity

The EMBO journal, 1995-08, Vol.14 (15), p.3820-3827

1995

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A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation

The Journal of biological chemistry, 2004-07, Vol.279 (27), p.27905-27914

2004

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MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation

Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886

Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors

An absolute requirement for Cubitus interruptus in Hedgehog signaling

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus

Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile

In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics

Trisubstituted ureas as potent and selective mPGES-1 inhibitors

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

Inhibition of the Activation of Multiple Serine Proteases with a Cathepsin C Inhibitor Requires Sustained Exposure to Prevent Pro-enzyme Processing

Inhibitors of the inducible microsomal prostaglandin E 2 synthase (mPGES-1) derived from MK-886

The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis

A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3

Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR

Fourier transform infrared and hydrogen/deuterium exchange reveal an exchange-resistant core of alpha-helical peptide hydrogens in the nicotinic acetylcholine receptor

Structure of the Pore-forming Transmembrane Domain of a Ligand-gated Ion Channel

Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange

Secondary Structure Analysis of Individual Transmembrane Segments of the Nicotinic Acetylcholine Receptor by Circular Dichroism and Fourier Transform Infrared Spectroscopy

The Human Homologue of the Yeast Prt1 Protein Is an Integral Part of the Eukaryotic Initiation Factor 3 Complex and Interacts with p170

Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B have RNA annealing activity

A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation

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