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Viral contamination in biologic manufacture and implications for emerging therapies

Nature biotechnology, 2020-05, Vol.38 (5), p.563-572

2020

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ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

Immunity (Cambridge, Mass.), 2001-02, Vol.14 (2), p.123-133

2001

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Epstein-Barr Virus Uses Different Complexes of Glycoproteins gH and gL To Infect B Lymphocytes and Epithelial Cells

Journal of Virology, 1998-07, Vol.72 (7), p.5552-5558

1998

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Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses

European journal of biochemistry, 2001-01, Vol.268 (1), p.160-167

2001

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Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries

Journal of immunological methods, 2004-06, Vol.289 (1), p.65-80

2004

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Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF

The Journal of biological chemistry, 2012-03, Vol.287 (10), p.7446-7455

2012

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A New Type of Cytokine Receptor Antagonist Directly Targeting gp130

The Journal of biological chemistry, 1998-10, Vol.273 (42), p.27213-27219

1998

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ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells

European journal of immunology, 2001-05, Vol.31 (5), p.1428-1437

2001

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ULBP1, 2, 3: novel MHC class I‐related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells

European journal of immunology, 2001-05, Vol.31 (5), p.1428-1437

2001

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The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6

The Journal of experimental medicine, 1996-04, Vol.183 (4), p.1399-1406

1996

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The importance of shedding of membrane proteins for cytokine biology

European cytokine network (Montrouge), 2000-03, Vol.11 (1), p.27-38

2000

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A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor

The Journal of immunology (1950), 1995-12, Vol.155 (11), p.5198-5205

1995

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Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins

Biochemical journal, 2001-02, Vol.353 (Pt 3), p.663-672

2001

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The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site

The Journal of immunology (1950), 1994-05, Vol.152 (10), p.4958-4968

1994

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Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6

The Journal of biological chemistry, 1999-04, Vol.274 (17), p.11859-11867

1999

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Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins

European journal of biochemistry, 2000-05, Vol.267 (9), p.2624-2631

2000

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Historical evaluation of the in vivo adventitious virus test and its potential for replacement with next generation sequencing (NGS)

Biologicals, 2023-02, Vol.81, p.101661-101661, Article 101661

2023

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The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentation

Journal of Virology, 1996-08, Vol.70 (8), p.5557-5563

1996

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Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor

The Journal of biological chemistry, 1994-07, Vol.269 (29), p.19014-19020

1994

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Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction

The Journal of immunology (1950), 1994-08, Vol.153 (4), p.1744-1753

1994

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Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding

The Journal of biological chemistry, 1993-07, Vol.268 (20), p.15285-15290

1993

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Corrigendum to “Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries” [J. Immunol. Methods. 289 (2004) 65–80]

Journal of immunological methods, 2004-11, Vol.294 (1), p.209-209

2004

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Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor

Biochemical and biophysical research communications, 1992-12, Vol.189 (2), p.794-800

1992

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Differential shedding of the two subunits of the interleukin-6 receptor

FEBS letters, 1993-10, Vol.332 (1), p.174-178

1993

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Biopharmaceutical Industry Approaches to Facility Segregation for Viral Safety: An Effort from the Consortium on Adventitious Agent Contamination in Biomanufacturing

PDA journal of pharmaceutical science and technology, 2019-03, Vol.73 (2), p.191-203

2019

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Viral contamination in biologic manufacture and implications for emerging therapies

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

Epstein-Barr Virus Uses Different Complexes of Glycoproteins gH and gL To Infect B Lymphocytes and Epithelial Cells

Soluble gp130 is the natural inhibitor of soluble interleukin‐6 receptor transsignaling responses

Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries

Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF

A New Type of Cytokine Receptor Antagonist Directly Targeting gp130

ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells

ULBP1, 2, 3: novel MHC class I‐related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6

The importance of shedding of membrane proteins for cytokine biology

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor

Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site

Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6

Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins

Historical evaluation of the in vivo adventitious virus test and its potential for replacement with next generation sequencing (NGS)

The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentation

Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction

Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding

Corrigendum to “Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries” [J. Immunol. Methods. 289 (2004) 65–80]

Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor

Differential shedding of the two subunits of the interleukin-6 receptor

Biopharmaceutical Industry Approaches to Facility Segregation for Viral Safety: An Effort from the Consortium on Adventitious Agent Contamination in Biomanufacturing

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