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The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Nature communications, 2020-03, Vol.11 (1), p.1491-12, Article 1491

2020

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Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

Journal of medicinal chemistry, 2011-05, Vol.54 (9), p.3206-3221

2011

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Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

The Journal of pharmacology and experimental therapeutics, 2014-09, Vol.350 (3), p.589-604

2014

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Antagonism of the 5-HT6 receptor – Preclinical rationale for the treatment of Alzheimer's disease

Neuropharmacology, 2017-10, Vol.125, p.50-63

2017

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Involvement of presynaptic 5-HT1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats

Pharmacology, biochemistry and behavior, 2017-02, Vol.153, p.141-146

2017

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Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

Pharmacology, biochemistry and behavior, 2013-04, Vol.105, p.41-50

2013

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Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

Behavioural brain research, 2013-03, Vol.240, p.146-152

2013

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Effects of the 5-HT6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex

European journal of pharmacology, 2017-03, Vol.799, p.1-6

2017

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Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration

Brain research, 2014-01, Vol.1543, p.253-262

2014

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Involvement of presynaptic 5-HT 1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats

Pharmacology, biochemistry and behavior, 2017-02, Vol.153, p.141-146

2017

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The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus

Neuropharmacology, 2016-08, Vol.107, p.351-363

2016

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Combined In Vivo Microdialysis and PET Studies to Validate [ 11 C]Yohimbine Binding as a Marker of Noradrenaline Release

Biomolecules (Basel, Switzerland), 2023-04, Vol.13 (4), p.674

2023

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A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission

Translational psychiatry, 2017-11, Vol.7 (11), p.1261-12, Article 1261

2017

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HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

Journal of neurochemistry, 2010-10, Vol.115 (1), p.209-219

2010

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Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites

Pharmacology, biochemistry and behavior, 2016-11, Vol.150-151, p.147-152

2016

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Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat

Brain research, 2006-09, Vol.1110 (1), p.221-225

2006

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Hippocampal P3-like auditory event-related potentials are disrupted in a rat model of cholinergic degeneration in Alzheimer's disease: reversal by donepezil treatment

Journal of Alzheimer's disease, 2014-01, Vol.42 (4), p.1179-1189

2014

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Nest building performance following MPTP toxicity in mice

Behavioural brain research, 2010-04, Vol.208 (2), p.444-449

2010

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Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved

Psychopharmacologia, 2009-09, Vol.206 (1), p.39-49

2009

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Auditory sensory processing deficits in sensory gating and mismatch negativity-like responses in the social isolation rat model of schizophrenia

Behavioural brain research, 2014-06, Vol.266, p.85-93

2014

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Disruption of Neurogenesis on Gestational Day 17 in the Rat Causes Behavioral Changes Relevant to Positive and Negative Schizophrenia Symptoms and Alters Amphetamine-Induced Dopamine Release in Nucleus Accumbens

Neuropsychopharmacology, 2004-11, Vol.29 (11), p.2052-2064

2004

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Combination of escitalopram and a 5-HT1A receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT2C receptor stimulation; suggestive of antipsychotic potential

Pharmacology, biochemistry and behavior, 2011-01, Vol.97 (3), p.479-485

2011

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Relevance of dorsal raphe nucleus firing in serotonin 5-HT2C receptor blockade-induced augmentation of SSRIs effects

Neuropharmacology, 2009-07, Vol.57 (1), p.18-24

2009

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The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels

Brain research, 2004-10, Vol.1024 (1), p.183-192

2004

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Inactivation of 5-HT2C receptors potentiates consequences of serotonin reuptake blockade

Neuropsychopharmacology (New York, N.Y.), 2004-10, Vol.29 (10), p.1782-1789

2004

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The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

Antagonism of the 5-HT6 receptor – Preclinical rationale for the treatment of Alzheimer's disease

Involvement of presynaptic 5-HT1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats

Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats

Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice

Effects of the 5-HT6 receptor antagonist idalopirdine on extracellular levels of monoamines, glutamate and acetylcholine in the rat medial prefrontal cortex

Impaired hippocampal acetylcholine release parallels spatial memory deficits in Tg2576 mice subjected to basal forebrain cholinergic degeneration

Involvement of presynaptic 5-HT 1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats

The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus

Combined In Vivo Microdialysis and PET Studies to Validate [ 11 C]Yohimbine Binding as a Marker of Noradrenaline Release

A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites

Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat

Hippocampal P3-like auditory event-related potentials are disrupted in a rat model of cholinergic degeneration in Alzheimer's disease: reversal by donepezil treatment

Nest building performance following MPTP toxicity in mice

Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved

Auditory sensory processing deficits in sensory gating and mismatch negativity-like responses in the social isolation rat model of schizophrenia

Disruption of Neurogenesis on Gestational Day 17 in the Rat Causes Behavioral Changes Relevant to Positive and Negative Schizophrenia Symptoms and Alters Amphetamine-Induced Dopamine Release in Nucleus Accumbens

Combination of escitalopram and a 5-HT1A receptor antagonist selectively decreases the extracellular levels of dopamine in the nucleus accumbens relative to striatum through 5-HT2C receptor stimulation; suggestive of antipsychotic potential

Relevance of dorsal raphe nucleus firing in serotonin 5-HT2C receptor blockade-induced augmentation of SSRIs effects

The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels

Inactivation of 5-HT2C receptors potentiates consequences of serotonin reuptake blockade

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