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Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome

Genes & development, 2020-08, Vol.34 (15-16), p.1005-1016

2020

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Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing

PLoS pathogens, 2013-06, Vol.9 (6), p.e1003460-e1003460

2013

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HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly

Molecular cell, 2013-03, Vol.49 (5), p.972-982

2013

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A new view of transcriptome complexity and regulation through the lens of local splicing variations

eLife, 2016-02, Vol.5, p.e11752

2016

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Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

Molecular cell, 2010-10, Vol.40 (1), p.126-137

2010

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Identifying common transcriptome signatures of cancer by interpreting deep learning models

Genome Biology, 2022-05, Vol.23 (1), p.117-117, Article 117

2022

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HnRNP L represses cryptic exons

RNA (Cambridge), 2018-06, Vol.24 (6), p.761-768

2018

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Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (15), p.e2014967118

2021

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Alternative 3′UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner

Scientific reports, 2024-05, Vol.14 (1), p.10987-14, Article 10987

2024

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Stem-Loop Recognition by DDX17 Facilitates miRNA Processing and Antiviral Defense

Cell, 2014-08, Vol.158 (4), p.764-777

2014

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RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus

PLoS pathogens, 2022-11, Vol.18 (11), p.e1010930

2022

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Viral-induced alternative splicing of host genes promotes influenza replication

eLife, 2020-12, Vol.9

2020

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Minimal functional domains of paralogues hnRNP L and hnRNP LL exhibit mechanistic differences in exonic splicing repression

Biochemical journal, 2013-07, Vol.453 (2), p.271-279

2013

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Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing

Nature communications, 2018-06, Vol.9 (1), p.2407-12, Article 2407

2018

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Regulation of Alternative Splicing: More than Just the ABCs

The Journal of biological chemistry, 2008-01, Vol.283 (3), p.1217-1221

2008

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MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

Nature communications, 2021-06, Vol.12 (1), p.3353-3353, Article 3353

2021

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Aberrant splicing in B-cell acute lymphoblastic leukemia

Nucleic acids research, 2018-11, Vol.46 (21), p.11357

2018

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Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes

Genome research, 2017-08, Vol.27 (8), p.1360-1370

2017

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RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery

Cell reports (Cambridge), 2019-09, Vol.28 (11), p.2795-2806.e3

2019

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Alternative splicing of HDAC7 regulates its interaction with 14-3-3 proteins to alter histone marks and target gene expression

Cell reports (Cambridge), 2023-03, Vol.42 (3), p.112273-112273, Article 112273

2023

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Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex

Nature communications, 2023-04, Vol.14 (1), p.2304-2304, Article 2304

2023

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Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (17), p.E2139-E2148

2015

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Alternative splicing of apoptosis genes promotes human T cell survival

eLife, 2022-10, Vol.11

2022

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Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly

Cell reports (Cambridge), 2023-08, Vol.42 (8), p.112988-112988, Article 112988

2023

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PSF: nuclear busy-body or nuclear facilitator?

Wiley interdisciplinary reviews. RNA, 2015-07, Vol.6 (4), p.351-367

2015

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Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome

Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly

A new view of transcriptome complexity and regulation through the lens of local splicing variations

Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative Splicing

Identifying common transcriptome signatures of cancer by interpreting deep learning models

HnRNP L represses cryptic exons

Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia

Alternative 3′UTR expression induced by T cell activation is regulated in a temporal and signal dependent manner

Stem-Loop Recognition by DDX17 Facilitates miRNA Processing and Antiviral Defense

RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus

Viral-induced alternative splicing of host genes promotes influenza replication

Minimal functional domains of paralogues hnRNP L and hnRNP LL exhibit mechanistic differences in exonic splicing repression

Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing

Regulation of Alternative Splicing: More than Just the ABCs

MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis

Aberrant splicing in B-cell acute lymphoblastic leukemia

Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes

RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery

Alternative splicing of HDAC7 regulates its interaction with 14-3-3 proteins to alter histone marks and target gene expression

Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex

Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling

Alternative splicing of apoptosis genes promotes human T cell survival

Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly

PSF: nuclear busy-body or nuclear facilitator?

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