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Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

The Journal of clinical investigation, 2000-01, Vol.105 (1), p.3-7

2000

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Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative

Cancer research (Chicago, Ill.), 1996, Vol.56 (1), p.100-104

1996

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Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

The New England journal of medicine, 2001-04, Vol.344 (14), p.1031-1037

2001

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Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

The Journal of pharmacology and experimental therapeutics, 2000-10, Vol.295 (1), p.139

2000

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

Nature medicine, 1996-05, Vol.2 (5), p.561-566

1996

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The structure-based design of ATP-site directed protein kinase inhibitors

Current medicinal chemistry, 1999-09, Vol.6 (9), p.775-805

1999

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Selective Inhibition of the Platelet-Derived Growth Factor Signal Transduction Pathway by a Protein-Tyrosine Kinase Inhibitor of the 2- Phenylaminopyrimidine Class

Proceedings of the National Academy of Sciences - PNAS, 1995-03, Vol.92 (7), p.2558-2562

1995

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Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives

Bioorganic & medicinal chemistry letters, 1997-01, Vol.7 (2), p.187-192

1997

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Src Phosphorylation of the Epidermal Growth Factor Receptor at Novel Sites Mediates Receptor Interaction with Src and P85α(∗)

The Journal of biological chemistry, 1995-06, Vol.270 (26), p.15591-15597

1995

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Inhibition of the ABL Kinase Activity Blocks the Proliferation of BCR/ABL+Leukemic Cells and Induces Apoptosis

Blood cells, molecules, & diseases, 1997-12, Vol.23 (3), p.380-394

1997

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4,5-Dianilinophthalimide: A Protein-Tyrosine Kinase Inhibitor with Selectivity for the Epidermal Growth Factor Receptor Signal Transduction Pathway and Potent in vivo Antitumor Activity

Proceedings of the National Academy of Sciences - PNAS, 1994-03, Vol.91 (6), p.2334-2338

1994

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Structures of staurosporine bound to CDK2 and cAPK – new tools for structure-based design of protein kinase inhibitors

Structure, 1997-12, Vol.5 (12), p.1551-1556

1997

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Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src

Oncogene, 1999-08, Vol.18 (33), p.4647-4653

1999

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Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

Archiv der Pharmazie (Weinheim), 1996-07, Vol.329 (7), p.371-376

1996

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The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells

Blood, 1997-11, Vol.90 (9), p.3691-3698

1997

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Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors

The Journal of biological chemistry, 1990-12, Vol.265 (36), p.22255-22261

1990

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Modulation of the SH2 Binding Specificity and Kinase Activity of Src by Tyrosine Phosphorylation within Its SH2 Domain (∗)

The Journal of biological chemistry, 1996-05, Vol.271 (21), p.12481-12487

1996

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A potent protein‐tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor‐expressing tumor cells in vitro and in vivo

International journal of cancer, 1998-03, Vol.76 (1), p.154-163

1998

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Benzopyranones and benzothiopyranones : a class of tyrosine protein kinase inhibitors with selectivity for the v-abl kinase

Cancer research (Chicago, Ill.), 1992-08, Vol.52 (16), p.4492-4498

1992

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Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

Journal of medicinal chemistry, 1997-10, Vol.40 (22), p.3601-3616

1997

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Expression and partial characterization of rat protein kinase C-δ and protein kinase C-ξ in insect cells using recombinant baculovirus

Journal of cellular biochemistry, 1992-07, Vol.49 (3), p.239-250

1992

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Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148)

Clinical cancer research, 1998-07, Vol.4 (7), p.1661-1672

1998

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Expression and partial characterization of rat protein kinase C-delta and protein kinase C-zeta in insect cells using recombinant baculovirus

Journal of cellular biochemistry, 1992-07, Vol.49 (3), p.239

1992

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Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer

Cancer research (Chicago, Ill.), 1994-01, Vol.54 (1), p.16-20

1994

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A strategy for screening anti‐tumor drugs utilizing oncogenes encoded in retroviral vectors

International journal of cancer, 1996-06, Vol.66 (6), p.753-759

1996

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Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

The structure-based design of ATP-site directed protein kinase inhibitors

Selective Inhibition of the Platelet-Derived Growth Factor Signal Transduction Pathway by a Protein-Tyrosine Kinase Inhibitor of the 2- Phenylaminopyrimidine Class

Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives

Src Phosphorylation of the Epidermal Growth Factor Receptor at Novel Sites Mediates Receptor Interaction with Src and P85α(∗)

Inhibition of the ABL Kinase Activity Blocks the Proliferation of BCR/ABL+Leukemic Cells and Induces Apoptosis

4,5-Dianilinophthalimide: A Protein-Tyrosine Kinase Inhibitor with Selectivity for the Epidermal Growth Factor Receptor Signal Transduction Pathway and Potent in vivo Antitumor Activity

Structures of staurosporine bound to CDK2 and cAPK – new tools for structure-based design of protein kinase inhibitors

Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src

Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells

Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors

Modulation of the SH2 Binding Specificity and Kinase Activity of Src by Tyrosine Phosphorylation within Its SH2 Domain (∗)

A potent protein‐tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor‐expressing tumor cells in vitro and in vivo

Benzopyranones and benzothiopyranones : a class of tyrosine protein kinase inhibitors with selectivity for the v-abl kinase

Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

Expression and partial characterization of rat protein kinase C-δ and protein kinase C-ξ in insect cells using recombinant baculovirus

Selective inhibition of cell proliferation and BCR-ABL phosphorylation in acute lymphoblastic leukemia cells expressing Mr 190,000 BCR-ABL protein by a tyrosine kinase inhibitor (CGP-57148)

Expression and partial characterization of rat protein kinase C-delta and protein kinase C-zeta in insect cells using recombinant baculovirus

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer

A strategy for screening anti‐tumor drugs utilizing oncogenes encoded in retroviral vectors

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