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Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor

Clinical pharmacokinetics, 2021-05, Vol.60 (5), p.569-583

2021

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Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition

Biochimica et biophysica acta. General subjects, 2020-04, Vol.1864 (4), p.129531-129531, Article 129531

2020

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Physiologically‐Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID‐19

Clinical pharmacology and therapeutics, 2021-04, Vol.109 (4), p.1116-1124

2021

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Cytochrome P450 3A Induction Predicts P‐glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1182-1190

2018

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Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Clinical pharmacology and therapeutics, 2021-01, Vol.109 (1), p.55-64

2021

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Cytochrome P450 3A Induction Predicts P‐glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1191-1198

2018

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Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions

Drug metabolism and disposition, 2013-07, Vol.41 (7), p.1414-1424

2013

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Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.159-168

2012

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A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

The Journal of infectious diseases, 2014-01, Vol.209 (2), p.275-284

2014

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Direct protein–protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1

FEBS letters, 2016-08, Vol.590 (16), p.2527-2535

2016

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Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat

Clinical pharmacology and therapeutics, 2021-05, Vol.109 (5), p.1334-1341

2021

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Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases

Biochemical pharmacology, 2012-01, Vol.83 (1), p.149-163

2012

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Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator

British journal of clinical pharmacology, 2017-02, Vol.83 (2), p.370-380

2017

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Importance of Multi-P450 Inhibition in Drug–Drug Interactions: Evaluation of Incidence, Inhibition Magnitude, and Prediction from in Vitro Data

Chemical research in toxicology, 2012-11, Vol.25 (11), p.2285-2300

2012

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In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors

Expert opinion on drug metabolism & toxicology, 2012-04, Vol.8 (4), p.449-466

2012

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Rationalization and prediction of in vivo metabolite exposures: the role of metabolite kinetics, clearance predictions and in vitro parameters

Expert opinion on drug metabolism & toxicology, 2010-09, Vol.6 (9), p.1095-1109

2010

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Safety, Pharmacokinetics and Pharmacodynamics of Selgantolimod, an Oral Toll-Like Receptor 8 Agonist: A Phase Ia Study in Healthy Subjects

Antiviral therapy, 2020-01, Vol.25 (3), p.171-180

2020

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Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

Biochemical pharmacology, 2009-01, Vol.77 (2), p.258-268

2009

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Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2056-2065

2013

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Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.426-435

2012

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Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics

Pharmacogenomics, 2014-12, Vol.15 (16), p.1947-1962

2014

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Resistance Analysis of Bictegravir-Emtricitabine-Tenofovir Alafenamide in HIV-1 Treatment-Naive Patients through 48 Weeks

Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5)

2019

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Fluoxetine- and Norfluoxetine-Mediated Complex Drug-Drug Interactions: In Vitro to In Vivo Correlation of Effects on CYP2D6, CYP2C19, and CYP3A4

Clinical pharmacology and therapeutics, 2014-06, Vol.95 (6), p.653-662

2014

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Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications

Clinical pharmacology and therapeutics, 2020-07, Vol.109 (1), p.55-64

2020

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Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor

Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition

Physiologically‐Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID‐19

Cytochrome P450 3A Induction Predicts P‐glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Cytochrome P450 3A Induction Predicts P‐glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine

Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions

Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole

A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation

Direct protein–protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1

Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat

Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases

Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator

Importance of Multi-P450 Inhibition in Drug–Drug Interactions: Evaluation of Incidence, Inhibition Magnitude, and Prediction from in Vitro Data

In vitro-to-in vivo predictions of drug-drug interactions involving multiple reversible inhibitors

Rationalization and prediction of in vivo metabolite exposures: the role of metabolite kinetics, clearance predictions and in vitro parameters

Safety, Pharmacokinetics and Pharmacodynamics of Selgantolimod, an Oral Toll-Like Receptor 8 Agonist: A Phase Ia Study in Healthy Subjects

Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems

Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals

Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics

Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM

Resistance Analysis of Bictegravir-Emtricitabine-Tenofovir Alafenamide in HIV-1 Treatment-Naive Patients through 48 Weeks

Fluoxetine- and Norfluoxetine-Mediated Complex Drug-Drug Interactions: In Vitro to In Vivo Correlation of Effects on CYP2D6, CYP2C19, and CYP3A4

Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications

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