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What have we learned from gene expression profiles in Huntington's disease?

Neurobiology of disease, 2012-01, Vol.45 (1), p.83-98

2012

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MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms

PloS one, 2013-01, Vol.8 (1), p.e54222-e54222

2013

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Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Nature methods, 2011-11, Vol.8 (11), p.945

2011

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Sustained effects of nonallele-specific Huntingtin silencing

Annals of neurology, 2009-03, Vol.65 (3), p.276-285

2009

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The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

Nature communications, 2023-10, Vol.14 (1), p.6750-6750, Article 6750

2023

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Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation

PloS one, 2011-07, Vol.6 (7), p.e22231

2011

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Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

The Journal of clinical investigation, 2011-08, Vol.121 (8), p.3306-3319

2011

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SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (17), p.7927-7932

2010

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HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration

PLoS biology, 2013-11, Vol.11 (11), p.e1001717-e1001717

2013

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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

The Journal of neuroscience, 2003-10, Vol.23 (28), p.9418-9427

2003

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MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition

The Journal of neuroscience, 2013-02, Vol.33 (6), p.2313-2325

2013

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Tubulin and Tubulin Posttranslational Modifications in Alzheimer's Disease and Vascular Dementia

Frontiers in aging neuroscience, 2021-10, Vol.13, p.730107-730107

2021

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Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

Neurobiology of disease, 2011-06, Vol.42 (3), p.459-467

2011

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Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease

PloS one, 2012-07, Vol.7 (7), p.e41423

2012

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Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (36), p.14424-14429

2007

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Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

BMC bioinformatics, 2008-01, Vol.9 (1), p.26-26, Article 26

2008

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HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo

PloS one, 2013-11, Vol.8 (11), p.e80849-e80849

2013

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Expression analysis of novel striatal-enriched genes in Huntington disease

Human molecular genetics, 2010-02, Vol.19 (4), p.609-622

2010

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Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data

BMC bioinformatics, 2006-04, Vol.7 (1), p.211-211, Article 211

2006

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A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease

Molecular & cellular proteomics, 2009-04, Vol.8 (4), p.720-734

2009

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Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

Frontiers in neuroscience, 2015-01, Vol.8, p.441-441

2015

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Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington’s Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter

Analytical chemistry (Washington), 2011-10, Vol.83 (20), p.7712-7720

2011

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Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Journal of neurochemistry, 2009-10, Vol.111 (2), p.460-472

2009

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Reply to Valenza and Cattaneo: SIRT2-mediated neuroprotection and cholesterol dyshomeostasis in Huntington’s disease

Proceedings of the National Academy of Sciences - PNAS, 2010-09, Vol.107 (37), p.E144-E144

2010

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What have we learned from gene expression profiles in Huntington's disease?

MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

Sustained effects of nonallele-specific Huntingtin silencing

The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition

Tubulin and Tubulin Posttranslational Modifications in Alzheimer's Disease and Vascular Dementia

Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease

Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease

Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood

Cross-species and cross-platform gene expression studies with the Bioconductor-compliant R package 'annotationTools'

HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo

Expression analysis of novel striatal-enriched genes in Huntington disease

Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data

A Large Number of Protein Expression Changes Occur Early in Life and Precede Phenotype Onset in a Mouse Model for Huntington Disease

Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington’s Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter

Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons

Reply to Valenza and Cattaneo: SIRT2-mediated neuroprotection and cholesterol dyshomeostasis in Huntington’s disease

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