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Airway smooth muscle stretch and airway hyperresponsiveness in asthma: have we chased the wrong horse?

Journal of applied physiology (1985), 2014-04, Vol.116 (8), p.1113-1115

Lutchen, Kenneth R

2014

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CFD Simulation of Aerosol Deposition in an Anatomically Based Human Large-Medium Airway Model

Annals of biomedical engineering, 2009-02, Vol.37 (2), p.271-285

2009

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A computational model of the response of adherent cells to stretch and changes in substrate stiffness

Journal of applied physiology (1985), 2014-04, Vol.116 (7), p.825-834

2014

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An anatomically based hybrid computational model of the human lung and its application to low frequency oscillatory mechanics

Annals of biomedical engineering, 2006-11, Vol.34 (11), p.1691-1704

2006

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The “Silent Zone” Screams Again: Identifying COPD Patients Most at Risk

Chest, 2021-04, Vol.159 (4), p.1313-1314

Lutchen, Kenneth R.

2021

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Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces

Journal of applied physiology (1985), 2005-05, Vol.98 (5), p.1892-1899

2005

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Correlated variability in the breathing pattern and end-expiratory lung volumes in conscious humans

PloS one, 2015-03, Vol.10 (3), p.e0116317-e0116317

2015

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Structure-function relations in an elastase-induced mouse model of emphysema

American journal of respiratory cell and molecular biology, 2011-09, Vol.45 (3), p.517-524

2011

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Elucidating the interaction between stretch and stiffness using an agent-based spring network model of progressive pulmonary fibrosis

Frontiers in network physiology, 2024-05, Vol.4, p.1396383

2024

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A mechanical design principle for tissue structure and function in the airway tree

PLoS computational biology, 2013-05, Vol.9 (5), p.e1003083-e1003083

2013

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Emergent behavior of regional heterogeneity in the lung and its effects on respiratory impedance

Journal of applied physiology (1985), 2011-05, Vol.110 (5), p.1473-1481

2011

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The role of heterogeneity in asthma: a structure-to-function perspective

Clinical and translational medicine, 2017-08, Vol.6 (1), p.1-11

2017

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Linking Ventilation Heterogeneity Quantified via Hyperpolarized 3He MRI to Dynamic Lung Mechanics and Airway Hyperresponsiveness

PloS one, 2015, Vol.10 (11), p.e0142738-e0142738

2015

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Invited Editorial on "Measurement of intraindividual airway tone heterogeneity and its importance in asthma": How does an airway and subsequently the lung become hyperresponsive?

Journal of applied physiology (1985), 2016-07, Vol.121 (1), p.221-222

Lutchen, Kenneth R

2016

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Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling

Journal of applied physiology (1985), 2005-02, Vol.98 (2), p.503-511

2005

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Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways

PloS one, 2014-04, Vol.9 (4), p.e94828-e94828

2014

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Effects of heterogeneities on the partitioning of airway and tissue properties in normal mice

Journal of applied physiology (1985), 2007-03, Vol.102 (3), p.859-869

2007

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Airway constriction pattern is a central component of asthma severity : The role of deep inspirations

American journal of respiratory and critical care medicine, 2001-07, Vol.164 (2), p.207-215

2001

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Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance

Journal of applied physiology (1985), 1997-10, Vol.83 (4), p.1192-1201

1997

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Tissue heterogeneity in the mouse lung: effects of elastase treatment

Journal of applied physiology (1985), 2004-07, Vol.97 (1), p.204-212

2004

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Selected contribution: airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations

Journal of applied physiology (1985), 2001-07, Vol.91 (1), p.506-515

2001

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Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?

Journal of applied physiology (1985), 2015-07, Vol.119 (1), p.47-54

2015

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A one-horse race can have only one winner

Journal of applied physiology (1985), 2014-04, Vol.116 (8), p.1119-1119

Lutchen, Kenneth R

2014

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Maintenance of airway caliber in isolated airways by deep inspiration and tidal strains

Journal of applied physiology (1985), 2008-08, Vol.105 (2), p.479-485

2008

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Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?

Journal of applied physiology (1985), 2013-08, Vol.115 (4), p.436-445

2013

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Airway smooth muscle stretch and airway hyperresponsiveness in asthma: have we chased the wrong horse?

CFD Simulation of Aerosol Deposition in an Anatomically Based Human Large-Medium Airway Model

A computational model of the response of adherent cells to stretch and changes in substrate stiffness

An anatomically based hybrid computational model of the human lung and its application to low frequency oscillatory mechanics

The “Silent Zone” Screams Again: Identifying COPD Patients Most at Risk

Biomechanics of the lung parenchyma: critical roles of collagen and mechanical forces

Correlated variability in the breathing pattern and end-expiratory lung volumes in conscious humans

Structure-function relations in an elastase-induced mouse model of emphysema

Elucidating the interaction between stretch and stiffness using an agent-based spring network model of progressive pulmonary fibrosis

A mechanical design principle for tissue structure and function in the airway tree

Emergent behavior of regional heterogeneity in the lung and its effects on respiratory impedance

The role of heterogeneity in asthma: a structure-to-function perspective

Linking Ventilation Heterogeneity Quantified via Hyperpolarized 3He MRI to Dynamic Lung Mechanics and Airway Hyperresponsiveness

Invited Editorial on "Measurement of intraindividual airway tone heterogeneity and its importance in asthma": How does an airway and subsequently the lung become hyperresponsive?

Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling

Tidal stretches differently regulate the contractile and cytoskeletal elements in intact airways

Effects of heterogeneities on the partitioning of airway and tissue properties in normal mice

Airway constriction pattern is a central component of asthma severity : The role of deep inspirations

Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance

Tissue heterogeneity in the mouse lung: effects of elastase treatment

Selected contribution: airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations

Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways?

A one-horse race can have only one winner

Maintenance of airway caliber in isolated airways by deep inspiration and tidal strains

Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation?

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