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Fatty acid synthase (FASN) as a therapeutic target in breast cancer

Expert opinion on therapeutic targets, 2017-11, Vol.21 (11), p.1001-1016

2017

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

Nature reviews. Cancer, 2007-10, Vol.7 (10), p.763-777

2007

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Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents

Current drug targets, 2017-01, Vol.18 (2), p.147

2017

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Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

Current pharmaceutical biotechnology, 2006-12, Vol.7 (6), p.483

2006

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Targeting Fatty Acid Synthase in Breast and Endometrial Cancer: An Alternative to Selective Estrogen Receptor Modulators?

Endocrinology (Philadelphia), 2006-09, Vol.147 (9), p.4056-4066

2006

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Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7661

2020

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Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

Cell death & disease, 2021-10, Vol.12 (11), p.977-977, Article 977

2021

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Metabolomic and Mitochondrial Fingerprinting of the Epithelial-to-Mesenchymal Transition (EMT) in Non-Tumorigenic and Tumorigenic Human Breast Cells

Cancers, 2022-12, Vol.14 (24), p.6214

2022

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Inhibition of Fatty Acid Synthase (FAS) Suppresses HER2/Neu (ErbB-2) Oncogene Overexpression in Cancer Cells

Proceedings of the National Academy of Sciences - PNAS, 2004-07, Vol.101 (29), p.10715-10720

2004

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Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer

Cancers, 2021-03, Vol.13 (5), p.1132

2021

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Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

Cell cycle (Georgetown, Tex.), 2013-09, Vol.12 (18), p.3109-3124

2013

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Heregulin Drives Endocrine Resistance by Altering IL-8 Expression in ER-Positive Breast Cancer

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7737

2020

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Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

Molecular oncology, 2024-03, Vol.18 (3), p.479-516

2024

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Heregulin in breast cancer: old story, new paradigm

Current pharmaceutical design, 2014-01, Vol.20 (30), p.4874

2014

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Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy

Cancers, 2020-07, Vol.12 (7), p.1757

2020

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Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells

Current opinion in clinical nutrition and metabolic care, 2006-07, Vol.9 (4), p.346-357

2006

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Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9)

Current pharmaceutical biotechnology, 2006-12, Vol.7 (6), p.495

2006

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Trastuzumab in Combination With Heregulin-Activated Her-2 (erbB-2) Triggers a Receptor-Enhanced Chemosensitivity Effect in the Absence of Her-2 Overexpression

Journal of clinical oncology, 2006-08, Vol.24 (23), p.3735-3746

2006

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Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

Proceedings of the National Academy of Sciences - PNAS, 1998-12, Vol.95 (25), p.14821-14826

1998

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Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER-2/neu-overexpressing human breast cancer cells to docetaxel (taxotere)

Breast cancer research and treatment, 2004-03, Vol.84 (2), p.183-195

2004

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Abstract 318: Inhibition of FASN induces apoptosis and senescence in breast cancer

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.318-318

2018

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Fatty acid synthase: a druggable driver of breast cancer brain metastasis

Expert opinion on therapeutic targets, 2022-05, Vol.26 (5), p.427-444

2022

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Transphosphorylation of kinase-dead HER3 and breast cancer progression: a new standpoint or an old concept revisited?

Breast cancer research : BCR, 2007-01, Vol.9 (5), p.111-111, Article 111

2007

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Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1

Journal of cellular physiology, 2008-09, Vol.216 (3), p.632-639

2008

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Abstract 708: Targeting fatty acid synthase induces apoptosis and senescence

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.708-708

2019

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Fatty acid synthase (FASN) as a therapeutic target in breast cancer

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

Natural Polyphenols and their Synthetic Analogs as Emerging Anticancer Agents

Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?

Targeting Fatty Acid Synthase in Breast and Endometrial Cancer: An Alternative to Selective Estrogen Receptor Modulators?

Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

Metabolomic and Mitochondrial Fingerprinting of the Epithelial-to-Mesenchymal Transition (EMT) in Non-Tumorigenic and Tumorigenic Human Breast Cells

Inhibition of Fatty Acid Synthase (FAS) Suppresses HER2/Neu (ErbB-2) Oncogene Overexpression in Cancer Cells

Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

Heregulin Drives Endocrine Resistance by Altering IL-8 Expression in ER-Positive Breast Cancer

Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology

Heregulin in breast cancer: old story, new paradigm

Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy

Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells

Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9)

Trastuzumab in Combination With Heregulin-Activated Her-2 (erbB-2) Triggers a Receptor-Enhanced Chemosensitivity Effect in the Absence of Her-2 Overexpression

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER-2/neu-overexpressing human breast cancer cells to docetaxel (taxotere)

Abstract 318: Inhibition of FASN induces apoptosis and senescence in breast cancer

Fatty acid synthase: a druggable driver of breast cancer brain metastasis

Transphosphorylation of kinase-dead HER3 and breast cancer progression: a new standpoint or an old concept revisited?

Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1

Abstract 708: Targeting fatty acid synthase induces apoptosis and senescence

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