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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6589), p.163-169

2022

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The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions

Frontiers in endocrinology (Lausanne), 2017-04, Vol.8, p.71-71

2017

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Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (22), p.8025-8030

2014

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The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

Structure (London), 2016-06, Vol.24 (6), p.897-905

2016

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Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

Neuron (Cambridge, Mass.), 2016-03, Vol.89 (5), p.983-999

2016

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Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

Cell, 2021-02, Vol.184 (4), p.983-999.e24

2021

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Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

The Journal of biological chemistry, 2013-09, Vol.288 (37), p.26926-26943

2013

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Structural biology of shared cytokine receptors

Annual review of immunology, 2009-01, Vol.27 (1), p.29-60

2009

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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

eLife, 2018-07, Vol.7

2018

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Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

Nature structural & molecular biology, 2014-05, Vol.21 (5), p.443-448

2014

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Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

Molecular cell, 2008-09, Vol.31 (5), p.737-748

2008

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Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag

PloS one, 2009-12, Vol.4 (12), p.e8119-e8119

2009

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The Structure of Interleukin-23 Reveals the Molecular Basis of p40 Subunit Sharing with Interleukin-12

Journal of molecular biology, 2008-10, Vol.382 (4), p.931-941

2008

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Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13R alpha 2

Structure (London), 2010-03, Vol.18 (3), p.332-342

2010

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Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

Science (American Association for the Advancement of Science), 2008-10, Vol.322 (5899), p.265-268

2008

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Mutation position is an important determinant for predicting cancer neoantigens

The Journal of experimental medicine, 2020-04, Vol.217 (4)

2020

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Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

mAbs, 2018-10, Vol.10 (7), p.979-13

2018

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Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody

PLoS pathogens, 2016-06, Vol.12 (6), p.e1005702-e1005702

2016

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An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

Cell host & microbe, 2013-07, Vol.14 (1), p.93-103

2013

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Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (12), p.1497-1501

2019

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Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2760-2779

2016

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An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

Molecular cell, 2003, Vol.11 (1), p.203-213

2003

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Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors

Journal of medicinal chemistry, 2019-07, Vol.62 (13), p.6223-6240

2019

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A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Nature communications, 2017-01, Vol.8 (1), p.14234-14234, Article 14234

2017

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Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex

Structure (London), 2011-01, Vol.19 (1), p.45-55

2011

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Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions

Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Structural biology of shared cytokine receptors

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex

Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag

The Structure of Interleukin-23 Reveals the Molecular Basis of p40 Subunit Sharing with Interleukin-12

Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13R alpha 2

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

Mutation position is an important determinant for predicting cancer neoantigens

Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Structural Snapshots of Full-Length Jak1, a Transmembrane gp130/IL-6/IL-6Rα Cytokine Receptor Complex, and the Receptor-Jak1 Holocomplex

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