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Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules

European journal of medicinal chemistry, 2020-01, Vol.186, p.111876-111876, Article 111876

2020

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Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

Acta pharmaceutica Sinica. B, 2021-05, Vol.11 (5), p.1300-1314

2021

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Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2‑Propanol-Mediated Reductive Coupling

Organic letters, 2018-07, Vol.20 (13), p.4144-4147

2018

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Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance

European journal of medicinal chemistry, 2020-11, Vol.206, p.112689-112689, Article 112689

2020

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A Comprehensive Overview of Small-Molecule Androgen Receptor Degraders: Recent Progress and Future Perspectives

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16128-16154

2022

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Targeting focal adhesion kinase (FAK) for cancer therapy: FAK inhibitors, FAK-based dual-target inhibitors and PROTAC degraders

Biochemical pharmacology, 2024-06, Vol.224, p.116246-116246, Article 116246

2024

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Dual-target inhibitors based on ERα: Novel therapeutic approaches for endocrine resistant breast cancer

European journal of medicinal chemistry, 2024-04, Vol.270, p.116393-116393, Article 116393

2024

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Hydrophobic tag tethering degrader as a promising paradigm of protein degradation: Past, present and future perspectives

Chinese chemical letters, 2024-08, Vol.35 (8), p.109192, Article 109192

2024

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Precisely Amplifying Intracellular Oxidative Storm by Metal–Organic Coordination Polymers to Augment Anticancer Immunity

ACS nano, 2023-08, Vol.17 (15), p.15165-15179

2023

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Discovery and Proof of Concept of Potent Dual Polθ/PARP Inhibitors for Efficient Treatment of Homologous Recombination-Deficient Tumors

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3606-3625

2024

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Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer

European journal of medicinal chemistry, 2021-12, Vol.226, p.113870-113870, Article 113870

2021

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Successive Nucleophilic and Electrophilic Allylation for the Catalytic Enantioselective Synthesis of 2,4-Disubstituted Pyrrolidines

Organic letters, 2019-04, Vol.21 (8), p.2493-2497

2019

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Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer

European journal of medicinal chemistry, 2021-10, Vol.221, p.113543-113543, Article 113543

2021

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Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities

Bioorganic & medicinal chemistry, 2021-10, Vol.47, p.116395-116395, Article 116395

2021

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Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer

Journal of medicinal chemistry, 2024-04, Vol.67 (7), p.5567-5590

2024

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Synthesis and evaluation of novel thiosemicarbazone and semicarbazone analogs with both anti-proliferative and anti-metastatic activities against triple negative breast cancer

Bioorganic & medicinal chemistry, 2021-05, Vol.37, p.116107-116107, Article 116107

2021

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Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity

European journal of medicinal chemistry, 2018-04, Vol.150, p.783-795

2018

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Novel 11β-substituted estradiol conjugates: Transition from ERα agonizts to effective PROTAC degraders

The Journal of steroid biochemistry and molecular biology, 2022-10, Vol.223, p.106154-106154, Article 106154

2022

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Discovery of novel steroidal-chalcone hybrids with potent and selective activity against triple-negative breast cancer

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (23), p.115763-115763, Article 115763

2020

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Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

European journal of medicinal chemistry, 2019-01, Vol.161, p.445-455

2019

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Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton - A possible way to dual ERα/VEGFR-2 ligands for treatment of breast cancer

European journal of medicinal chemistry, 2017-11, Vol.140, p.252-273

2017

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Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transferElectronic supplementary information (ESI) available: Experimental procedures and spectroscopic and HPLC data for all new compounds. Crystallographic data for compound 4c. CCDC 1873061. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8cc09706b

2019-01

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Design, synthesis and biological evaluation of novel 3-substituted 4-anilino-coumarin derivatives as antitumor agents

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.867-874

2017

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Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator

European journal of medicinal chemistry, 2021-01, Vol.209, p.112910-112910, Article 112910

2021

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Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer

Chemical communications (Cambridge, England), 2019-01, Vol.55 (7), p.981-984

2019

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Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2‑Propanol-Mediated Reductive Coupling

Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance

A Comprehensive Overview of Small-Molecule Androgen Receptor Degraders: Recent Progress and Future Perspectives

Targeting focal adhesion kinase (FAK) for cancer therapy: FAK inhibitors, FAK-based dual-target inhibitors and PROTAC degraders

Dual-target inhibitors based on ERα: Novel therapeutic approaches for endocrine resistant breast cancer

Hydrophobic tag tethering degrader as a promising paradigm of protein degradation: Past, present and future perspectives

Precisely Amplifying Intracellular Oxidative Storm by Metal–Organic Coordination Polymers to Augment Anticancer Immunity

Discovery and Proof of Concept of Potent Dual Polθ/PARP Inhibitors for Efficient Treatment of Homologous Recombination-Deficient Tumors

Development of novel tetrahydroisoquinoline-hydroxamate conjugates as potent dual SERDs/HDAC inhibitors for the treatment of breast cancer

Successive Nucleophilic and Electrophilic Allylation for the Catalytic Enantioselective Synthesis of 2,4-Disubstituted Pyrrolidines

Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer

Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities

Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer

Synthesis and evaluation of novel thiosemicarbazone and semicarbazone analogs with both anti-proliferative and anti-metastatic activities against triple negative breast cancer

Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity

Novel 11β-substituted estradiol conjugates: Transition from ERα agonizts to effective PROTAC degraders

Discovery of novel steroidal-chalcone hybrids with potent and selective activity against triple-negative breast cancer

Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton - A possible way to dual ERα/VEGFR-2 ligands for treatment of breast cancer

Design, synthesis and biological evaluation of novel 3-substituted 4-anilino-coumarin derivatives as antitumor agents

Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator

Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer

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