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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Nature communications, 2020-04, Vol.11 (1), p.1896-1896, Article 1896

2020

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A stop codon mutation in SCN9A causes lack of pain sensation

Human molecular genetics, 2007-09, Vol.16 (17), p.2114-2121

2007

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Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Nature biotechnology, 2022-07, Vol.40 (7), p.1042-1055

2022

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Intracellular Calcium Dependence of Large Dense-Core Vesicle Exocytosis in the Absence of Synaptotagmin I

Proceedings of the National Academy of Sciences - PNAS, 2001-09, Vol.98 (20), p.11680-11685

2001

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Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Proceedings of the National Academy of Sciences - PNAS, 2022-06, Vol.119 (24), p.e2120083119-e2120083119

2022

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RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Diabetologia, 2024-05

2024

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Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

Peptides (New York, N.Y. : 1980), 2013-06, Vol.44, p.40-46

2013

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Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability

Scientific reports, 2015-08, Vol.5 (1), p.13278-13278, Article 13278

2015

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Identification of novel NaV1.7 antagonists using high throughput screening platforms

Combinatorial chemistry & high throughput screening, 2012-11, Vol.15 (9), p.713

2012

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Biaryl sulfonamide motifs up- or down-regulate ion channel activity by activating voltage sensors

The Journal of general physiology, 2018-08, Vol.150 (8), p.1215-1230

2018

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Ion channel screening technology

CNS & neurological disorders drug targets, 2008-04, Vol.7 (2), p.122

2008

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In Vivo and Ex Vivo Inhibition of Spinal Nerve Ligation-Induced Ectopic Activity by Sodium Channel Blockers Correlate to In Vitro Inhibition of NaV1.7 and Clinical Efficacy: A Pharmacokinetic-Pharmacodynamic Translational Approach

Pharmaceutical research, 2013-05, Vol.30 (5), p.1409-1422

2013

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Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5618-5624

2012

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Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3871-3876

2011

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The Orexin OX1 Receptor Activates a Novel Ca2+ Influx Pathway Necessary for Coupling to Phospholipase C

The Journal of biological chemistry, 2000-10, Vol.275 (40), p.30806-30812

2000

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Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6108-6115

2012

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Reconstitution of neurotransmission by determining communication between differentiated PC12 pheochromocytoma and HEL 92.1.7 erythroleukemia cells

Pflügers Archiv, 2001-05, Vol.442 (2), p.312-320

2001

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Munc13-1 Promotes Secretory Granule Exocytosis Through Two Separate Calcium-Dependent Mechanisms

Biophysical journal, 2021-02, Vol.120 (3), p.51a-51a

2021

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Molecular Mechanisms of V-SNARE Function in Secretory Granule Exocytosis

Biophysical journal, 2017-02, Vol.112 (3), p.395a-395a

2017

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Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

The Journal of clinical investigation, 2017-06, Vol.127 (6), p.2353-2364

2017

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Ca^sup2+^ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

The Journal of clinical investigation, 2017-06, Vol.127 (6), p.2353

2017

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channel clustering with insulin-containing granules is disturbed in type 2 diabetes

The Journal of clinical investigation, 2017-06, Vol.127 (6), p.2353

2017

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3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models

Journal of medicinal chemistry, 2012-08, Vol.55 (15), p.6866-6880

2012

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Ca 2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

The Journal of clinical investigation, 2017, Vol.127 (6), p.2353

2017

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Local Changes of Medium in Studies of Individual Cells

Cell Structure and Function, 1994, Vol.19(6), pp.385-390

1994

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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

A stop codon mutation in SCN9A causes lack of pain sensation

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Intracellular Calcium Dependence of Large Dense-Core Vesicle Exocytosis in the Absence of Synaptotagmin I

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability

Identification of novel NaV1.7 antagonists using high throughput screening platforms

Biaryl sulfonamide motifs up- or down-regulate ion channel activity by activating voltage sensors

Ion channel screening technology

In Vivo and Ex Vivo Inhibition of Spinal Nerve Ligation-Induced Ectopic Activity by Sodium Channel Blockers Correlate to In Vitro Inhibition of NaV1.7 and Clinical Efficacy: A Pharmacokinetic-Pharmacodynamic Translational Approach

Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers

Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship

The Orexin OX1 Receptor Activates a Novel Ca2+ Influx Pathway Necessary for Coupling to Phospholipase C

Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship

Reconstitution of neurotransmission by determining communication between differentiated PC12 pheochromocytoma and HEL 92.1.7 erythroleukemia cells

Munc13-1 Promotes Secretory Granule Exocytosis Through Two Separate Calcium-Dependent Mechanisms

Molecular Mechanisms of V-SNARE Function in Secretory Granule Exocytosis

Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Ca^sup2+^ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

channel clustering with insulin-containing granules is disturbed in type 2 diabetes

3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models

Ca 2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Local Changes of Medium in Studies of Individual Cells

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