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Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations

International journal of environmental research and public health, 2016-10, Vol.13 (11), p.1-1

2016

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In vitro to in vivo extrapolation for high throughput prioritization and decision making

Toxicology in vitro, 2018-03, Vol.47, p.213-227

2018

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Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

Frontiers in pharmacology, 2021-09, Vol.12, p.692442-692442

2021

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Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives

Environment international, 2019-05, Vol.126, p.659-671

2019

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Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research

The Science of the total environment, 2018-12, Vol.645, p.97-108

2018

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Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy

NPJ systems biology and applications, 2020-11, Vol.6 (1), p.36-36, Article 36

2020

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IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making

Toxics (Basel), 2022-05, Vol.10 (5), p.232

2022

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An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science

Toxics (Basel), 2023-01, Vol.11 (2), p.126

2023

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Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

Genes & nutrition, 2017-09, Vol.12 (1), p.22-13, Article 22

2017

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Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system

Frontiers in pharmacology, 2015-05, Vol.6, p.107-107

2015

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Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges

Biochemical pharmacology, 2021-07, Vol.189, p.114468, Article 114468

2021

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Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp

PloS one, 2013-08, Vol.8 (8), p.e69394

2013

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Thiocyanate: a review and evaluation of the kinetics and the modes of action for thyroid hormone perturbations

Critical reviews in toxicology, 2017-08, Vol.47 (7), p.543-569

2017

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A Mechanistic Physiologically‐Based Pharmacokinetic Platform Model to Guide Adult and Pediatric Intravenous and Subcutaneous Dosing for Bispecific T Cell Engagers

Clinical pharmacology and therapeutics, 2024-03, Vol.115 (3), p.457-467

2024

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Predicting Clinical Pharmacokinetics/Pharmacodynamics and Impact of Organ Impairment on siRNA‐Based Therapeutics Using a Mechanistic Physiologically‐Based Pharmacokinetic‐Pharmacodynamic Model

Clinical pharmacology and therapeutics, 2024-05, Vol.115 (5), p.1054-1064

2024

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Characterization of the modes of action and dose-response relationship for thiocyanate on the thyroid hormone levels in rats using a computational approach

Toxicology and applied pharmacology, 2019-02, Vol.365 (C), p.84-100

2019

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Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid

Toxicology and applied pharmacology, 2016-09, Vol.307

2016

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The Hypothalamic-Pituitary-Thyroid Axis in Infants and Children: Protection from Radioiodines

Journal of Thyroid Research, 2014-01, Vol.2014 (2014), p.94-105

2014

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Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid

Toxicology and applied pharmacology, 2016-09, Vol.307 (C), p.19-34

2016

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Response of transposable elements to environmental stressors

Mutation research. Reviews in mutation research, 2015-07, Vol.765, p.19-39

2015

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PBPK model reporting template for chemical risk assessment applications

Regulatory toxicology and pharmacology, 2020-08, Vol.115, p.104691-104691, Article 104691

2020

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Evaluation of perturbations in serum thyroid hormones during human pregnancy due to dietary iodide and perchlorate exposure using a biologically based dose-response model

Toxicological sciences, 2013-06, Vol.133 (2), p.320-341

2013

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Evaluation of a rapid, generic human gestational dose model

Reproductive toxicology (Elmsford, N.Y.), 2022-10, Vol.113 (C)

2022

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Evaluation of a rapid, generic human gestational dose model

Reproductive toxicology (Elmsford, N.Y.), 2022-10, Vol.113 (C), p.172-188

2022

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If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

Drug metabolism and disposition, 2010-02, Vol.38 (2), p.260

2010

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Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations

In vitro to in vivo extrapolation for high throughput prioritization and decision making

Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives

Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research

Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy

IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making

An Overview of Physiologically-Based Pharmacokinetic Models for Forensic Science

Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system

Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges

Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp

Thiocyanate: a review and evaluation of the kinetics and the modes of action for thyroid hormone perturbations

A Mechanistic Physiologically‐Based Pharmacokinetic Platform Model to Guide Adult and Pediatric Intravenous and Subcutaneous Dosing for Bispecific T Cell Engagers

Predicting Clinical Pharmacokinetics/Pharmacodynamics and Impact of Organ Impairment on siRNA‐Based Therapeutics Using a Mechanistic Physiologically‐Based Pharmacokinetic‐Pharmacodynamic Model

Characterization of the modes of action and dose-response relationship for thiocyanate on the thyroid hormone levels in rats using a computational approach

Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid

The Hypothalamic-Pituitary-Thyroid Axis in Infants and Children: Protection from Radioiodines

Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid

Response of transposable elements to environmental stressors

PBPK model reporting template for chemical risk assessment applications

Evaluation of perturbations in serum thyroid hormones during human pregnancy due to dietary iodide and perchlorate exposure using a biologically based dose-response model

Evaluation of a rapid, generic human gestational dose model

Evaluation of a rapid, generic human gestational dose model

If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?

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