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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Journal of medicinal chemistry, 2019-07, Vol.62 (14), p.6575-6596

2019

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Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)

Bioorganic & medicinal chemistry letters, 2019-04, Vol.29 (8), p.1001-1006

2019

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Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains

ACS medicinal chemistry letters, 2017-08, Vol.8 (8), p.847-852

2017

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Titanium and Boron Mediated Aldol Reactions of .beta.-Hydroxy Ketones

Journal of organic chemistry, 1995-05, Vol.60 (10), p.3013-3019

1995

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An Efficient Preparation of β-Aryl-β-ketophosphonates by the TFAA/H3PO4-Mediated Acylation of Arenes with Phosphonoacetic Acids

Journal of organic chemistry, 2008-08, Vol.73 (16), p.6397-6400

2008

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Lewis Acid Promoted Additions of .gamma.-Alkoxy- and -(Silyloxy)crotylstannanes to (S)-2-(Benzyloxy)propanal

Journal of organic chemistry, 1994-12, Vol.59 (25), p.7825-7832

1994

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Formation of 1,3-diynes, 1,3-dienes, and biphenyls via the copper(II) nitrate mediated coupling of organotin compounds

Journal of organic chemistry, 1987-09, Vol.52 (19), p.4296-4298

1987

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Bone-Targeted pyrido[2,3- d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (18), p.3071-3074

2003

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Structure-Based Design of Novel Bicyclic Nonpeptide Inhibitors for the Src SH2 Domain

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3815-3819

2000

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Stereoselective total synthesis of bengamide E from glyceraldehyde acetonide and a nonracemic .gamma.-alkoxy allylic stannane

Journal of organic chemistry, 1993-11, Vol.58 (23), p.6229-6234

1993

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Synthesis of Protected Carbohydrate Derivatives Through Homologation of Threose and Erythrose Derivatives with Chiral .gamma.-Alkoxy Allylic Stannanes

Journal of organic chemistry, 1994-06, Vol.59 (12), p.3413-3420

1994

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Reaction of Phosgeniminium Salts with Enolates Derived from Lewis Acid Complexes of 2‘-Hydroxypropiophenones and Related β-Diketones

Journal of organic chemistry, 1996-05, Vol.61 (9), p.3218-3220

1996

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Synthesis of ( S)-5-(1-aminoethyl)-2-(cyclohexylmethoxy)benzamide

Tetrahedron: asymmetry, 1999-11, Vol.10 (22), p.4393-4403

1999

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A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) : Exploitation in the design of nonpeptide inhibitors of pp60Src SH2 domain

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2319-2323

2001

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An Efficient Preparation of β-Aryl-β-ketophosphonates by the TFAA/H 3 PO 4 -Mediated Acylation of Arenes with Phosphonoacetic Acids

Journal of organic chemistry, 2008-08, Vol.73 (16), p.6397-6400

2008

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Diastereoselective additions of enantioenriched .gamma.-(alkoxy)allyl stannanes to .alpha.-alkoxy aldehydes: a synthetic route to carbohydrates

Journal of organic chemistry, 1991-01, Vol.56 (2), p.483-485

1991

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A SIMPLE AND EFFICIENT PREPARATION OF (ARYLPHOSPHINYL)-METHYLPHOSPHONATES

Synthetic communications, 2002-01, Vol.32 (19), p.2951-2957

2002

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Structure-based design and synthesis of a novel class of Src SH2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-08, Vol.9 (16), p.2353-2358

1999

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A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2319-2323

2001

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Diastereoselective additions of enantioenriched (γ-alkoxyallyl)stannanes to α-alkoxy aldehydes : a synthetic route to carbohydrates

Journal of organic chemistry, 1991-01, Vol.56 (2), p.483-485

1991

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Stereoselective Synthesis of a Bengamide E Derivative Through S E′ Addition of a Chiral γ-Alkoxy Allylic Stannane to a Tartrate-Derived α, β-Dialkoxy Aldehyde

Synlett, 1992-12, Vol.1992 (12), p.1007-1008

1992

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Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: Potent inhibitors of Src tyrosine kinase as novel antiresorptive agents: Recent advances in the design of kinase inhibitors as novel therapeutic agents

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (18), p.3071-3074

2003

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A titanium (IV) mediated one-pot double condensation synthesis of 5,6-dihydro-4H-pyran-4-ones

Tetrahedron, 1997-08, Vol.53 (32), p.11211-11222

1997

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A titanium (IV) mediated one-pot double condensation synthesis of 5,6-dihydro-4 H-pyran-4-ones

Tetrahedron, 1997, Vol.53 (32), p.11211-11222

1997

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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)

Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains

Titanium and Boron Mediated Aldol Reactions of .beta.-Hydroxy Ketones

An Efficient Preparation of β-Aryl-β-ketophosphonates by the TFAA/H3PO4-Mediated Acylation of Arenes with Phosphonoacetic Acids

Lewis Acid Promoted Additions of .gamma.-Alkoxy- and -(Silyloxy)crotylstannanes to (S)-2-(Benzyloxy)propanal

Formation of 1,3-diynes, 1,3-dienes, and biphenyls via the copper(II) nitrate mediated coupling of organotin compounds

Bone-Targeted pyrido[2,3- d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents

Structure-Based Design of Novel Bicyclic Nonpeptide Inhibitors for the Src SH2 Domain

Stereoselective total synthesis of bengamide E from glyceraldehyde acetonide and a nonracemic .gamma.-alkoxy allylic stannane

Synthesis of Protected Carbohydrate Derivatives Through Homologation of Threose and Erythrose Derivatives with Chiral .gamma.-Alkoxy Allylic Stannanes

Reaction of Phosgeniminium Salts with Enolates Derived from Lewis Acid Complexes of 2‘-Hydroxypropiophenones and Related β-Diketones

Synthesis of ( S)-5-(1-aminoethyl)-2-(cyclohexylmethoxy)benzamide

FT-1101: A Structurally Distinct Pan-BET Bromodomain Inhibitor with Activity in Preclinical Models of Hematologic Malignancies

A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) : Exploitation in the design of nonpeptide inhibitors of pp60Src SH2 domain

An Efficient Preparation of β-Aryl-β-ketophosphonates by the TFAA/H 3 PO 4 -Mediated Acylation of Arenes with Phosphonoacetic Acids

Diastereoselective additions of enantioenriched .gamma.-(alkoxy)allyl stannanes to .alpha.-alkoxy aldehydes: a synthetic route to carbohydrates

A SIMPLE AND EFFICIENT PREPARATION OF (ARYLPHOSPHINYL)-METHYLPHOSPHONATES

Structure-based design and synthesis of a novel class of Src SH2 inhibitors

A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain

Diastereoselective additions of enantioenriched (γ-alkoxyallyl)stannanes to α-alkoxy aldehydes : a synthetic route to carbohydrates

Stereoselective Synthesis of a Bengamide E Derivative Through S E′ Addition of a Chiral γ-Alkoxy Allylic Stannane to a Tartrate-Derived α, β-Dialkoxy Aldehyde

Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: Potent inhibitors of Src tyrosine kinase as novel antiresorptive agents: Recent advances in the design of kinase inhibitors as novel therapeutic agents

A titanium (IV) mediated one-pot double condensation synthesis of 5,6-dihydro-4H-pyran-4-ones

A titanium (IV) mediated one-pot double condensation synthesis of 5,6-dihydro-4 H-pyran-4-ones

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