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Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents

Pharmacology & therapeutics (Oxford), 2006-03, Vol.109 (3), p.366-398

Lugnier, Claire

2006

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Mechanisms underlying vasorelaxation induced in the porcine coronary arteries by Thymus linearis, Benth

Journal of ethnopharmacology, 2018-10, Vol.225, p.211-219

2018

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Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

British journal of pharmacology, 2012-03, Vol.165 (5), p.1288-1305

2012

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Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the porcine coronary artery

Phytomedicine (Stuttgart), 2016-07, Vol.23 (8), p.793-799

2016

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Short‐term or long‐term treatments with a phosphodiesterase‐4 (PDE4) inhibitor result in opposing agonist‐induced Ca2+ responses in endothelial cells

British journal of pharmacology, 2008-05, Vol.154 (1), p.82-92

2008

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Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca(2+) responses in endothelial cells

British journal of pharmacology, 2008-05, Vol.154 (1), p.82-92

2008

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Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis

Cardiovascular research, 2003-08, Vol.59 (2), p.479-487

2003

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Application of drug repositioning strategy to TOFISOPAM

Current medicinal chemistry, 2008-12, Vol.15 (30), p.3196

2008

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PDE inhibitors: a new approach to treat metabolic syndrome?

Current opinion in pharmacology, 2011-12, Vol.11 (6), p.698-706

Lugnier, Claire

2011

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Design of Small-Sized Libraries by Combinatorial Assembly of Linkers and Functional Groups to a Given Scaffold: Application to the Structure-Based Optimization of a Phosphodiesterase 4 Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3816-3822

2005

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Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery

British journal of pharmacology, 2003-06, Vol.139 (3), p.513-522

2003

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Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs

Current pharmaceutical design, 2010-03, Vol.16 (9), p.1114

2010

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Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

Molecular nutrition & food research, 2011-11, Vol.55 (11), p.1677-1689

2011

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Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors

Planta medica, 2007-10, Vol.73 (12), p.1284-1286

2007

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Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7525-7545

2012

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Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition

Thrombosis and haemostasis, 2015-02, Vol.113 (2), p.319

2015

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PD-11 In depth analysis of label-free infrared (IR) imaging-based microsatellite instability (MSI) classification in early colon cancer (CC) on samples from the AIO ColoPredictPlus 2.0 (CPP) registry trial

Annals of oncology, 2022-06, Vol.33, p.S243

2022

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D020 The polyphenol curcumin inhibits in vitro angiogenesis and cyclic nucleotide phosphodiesterases (PDEs) activities similarly to PDE inhibitors

Archives of cardiovascular diseases, 2009-03, Vol.102, p.S43-S43

2009

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565P Real-world data of early-onset colon cancer (early-onset CC) from the AIO colopredict plus (CPP) registry: Clinical and molecular characteristics, treatment and outcome

Annals of oncology, 2023-10, Vol.34, p.S419-S419

2023

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Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells

PloS one, 2015-12, Vol.10 (12), p.e0145291-e0145291

2015

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407P Cross-sectoral colorectal cancer care in Germany in the context of the COVID-19 pandemic and scarcity of resources

Annals of oncology, 2022-09, Vol.33, p.S722-S722

2022

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Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

Biochemical pharmacology, 2010-05, Vol.79 (9), p.1251-1260

2010

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1333P S1 Guideline for prioritisation in gastrointestinal cancer care: Scarcity of resources in the pandemic context

Annals of oncology, 2022-09, Vol.33, p.S1150-S1150

2022

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Modulation of vascular cyclic nucleotide phosphodiesterases by cyclic GMP : role in vasodilatation

European heart journal, 1993-11, Vol.14, p.141-148

1993

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Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin

Current drug discovery technologies, 2005-09, Vol.2 (3), p.161

2005

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Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents

Mechanisms underlying vasorelaxation induced in the porcine coronary arteries by Thymus linearis, Benth

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

Endothelium-independent vasorelaxant effect of a Berberis orthobotrys root extract via inhibition of phosphodiesterases in the porcine coronary artery

Short‐term or long‐term treatments with a phosphodiesterase‐4 (PDE4) inhibitor result in opposing agonist‐induced Ca2+ responses in endothelial cells

Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca(2+) responses in endothelial cells

Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis

Application of drug repositioning strategy to TOFISOPAM

PDE inhibitors: a new approach to treat metabolic syndrome?

Design of Small-Sized Libraries by Combinatorial Assembly of Linkers and Functional Groups to a Given Scaffold: Application to the Structure-Based Optimization of a Phosphodiesterase 4 Inhibitor

Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery

Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs

Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1

Biflavones of Decussocarpus rospigliosii as phosphodiesterases inhibitors

Design, Synthesis, and Pharmacological Evaluation of N‑Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase‑4 Inhibitors

Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition

PD-11 In depth analysis of label-free infrared (IR) imaging-based microsatellite instability (MSI) classification in early colon cancer (CC) on samples from the AIO ColoPredictPlus 2.0 (CPP) registry trial

D020 The polyphenol curcumin inhibits in vitro angiogenesis and cyclic nucleotide phosphodiesterases (PDEs) activities similarly to PDE inhibitors

565P Real-world data of early-onset colon cancer (early-onset CC) from the AIO colopredict plus (CPP) registry: Clinical and molecular characteristics, treatment and outcome

Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells

407P Cross-sectoral colorectal cancer care in Germany in the context of the COVID-19 pandemic and scarcity of resources

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

1333P S1 Guideline for prioritisation in gastrointestinal cancer care: Scarcity of resources in the pandemic context

Modulation of vascular cyclic nucleotide phosphodiesterases by cyclic GMP : role in vasodilatation

Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin

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