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How can molecular abnormalities influence our clinical approach

Annals of oncology, 2017-11, Vol.28 (suppl_8), p.viii16-viii24

2017

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How can molecular abnormalities influence our clinical approach

Annals of oncology, 2017-11, Vol.28 Suppl 8, p.viii16

2017

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Investigation of the Effect of Lasmiditan on the Pharmacokinetics of P-Glycoprotein and Breast Cancer Resistance Protein Substrates

Journal of clinical pharmacology, 2024-01, Vol.64 (1), p.94-102

2024

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A decade of drug metabolite safety testing: industry and regulatory shared learning

Expert opinion on drug metabolism & toxicology, 2017-09, Vol.13 (9), p.897-900

2017

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A MIST conception: what has been learned from twenty years of human metabolite safety assessment?

Medicinal chemistry research, 2023-09, Vol.32 (9), p.1933-1949

2023

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PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab

Birth defects research, 2023-04, Vol.115 (7), p.782-796

2023

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Predicting Circulating Human Metabolites: How Good Are We?

Chemical research in toxicology, 2009-02, Vol.22 (2), p.243-256

2009

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Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase‐1

Journal of clinical pharmacology, 2018-04, Vol.58 (4), p.412-424

2018

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Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α

Clinical cancer research, 2018-02, Vol.24 (4), p.847-857

2018

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The Types of the Swedish Folk Legend by Bengt af Klintberg (review)

The Journal of American folklore, 2015, Vol.128 (507), p.97-99

Luffer, Jan

2015

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The early estimation of circulating drug metabolites in humans

Expert opinion on drug metabolism & toxicology, 2012-08, Vol.8 (8), p.985-997

Luffer-Atlas, Debra

2012

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Unique Major Human Metabolites: Why, How, and When to Test for Safety in Animals

Drug metabolism reviews, 2008-01, Vol.40 (3), p.447-463

Luffer-Atlas, Debra

2008

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A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations

Bioanalysis, 2010-07, Vol.2 (7), p.1195-1210

2010

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Morningness in Teachers is Related to a Higher Sense of Coherence and Lower Burnout

Social indicators research, 2015-06, Vol.122 (2), p.595-606

2015

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Population Pharmacokinetic Modeling of Olaratumab, an Anti-PDGFRα Human Monoclonal Antibody, in Patients with Advanced and/or Metastatic Cancer

Clinical pharmacokinetics, 2018-03, Vol.57 (3), p.355-365

2018

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Identification and Mitigation of Reactive Metabolites of 2‑Aminoimidazole-Containing Microsomal Prostaglandin E Synthase‑1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

Journal of medicinal chemistry, 2018-03, Vol.61 (5), p.2041-2051

2018

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A Strategy for the Risk Assessment of Human Genotoxic Metabolites

Chemical research in toxicology, 2009-02, Vol.22 (2), p.348-356

2009

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Overview of metabolite safety testing from an industry perspective

Bioanalysis, 2010-07, Vol.2 (7), p.1249-1261

2010

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Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats

The Journal of pharmacology and experimental therapeutics, 2017-07, Vol.362 (1), p.108

2017

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Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Journal of medicinal chemistry, 2003-11, Vol.46 (24), p.5121-5124

2003

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Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

European journal of nuclear medicine and molecular imaging, 2013, Vol.40 (2), p.245-253

2013

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TYPOLOGICKÁ KLASIFIKACE LIDOVÝCH POHÁDEK A POVĚSTÍ V MEZINÁRODNÍM KONTEXTU

Ceský lid, 2006-01, Vol.93 (3), p.287-302

LUFFER, JAN

2006

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Evaluation in vitro and in animals of a new ^sup 11^C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

European journal of nuclear medicine and molecular imaging, 2013-01, Vol.40 (2), p.245

2013

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Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes

Xenobiotica, 1998, Vol.28 (3), p.313-321

1998

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How can molecular abnormalities influence our clinical approach

How can molecular abnormalities influence our clinical approach

Investigation of the Effect of Lasmiditan on the Pharmacokinetics of P-Glycoprotein and Breast Cancer Resistance Protein Substrates

A decade of drug metabolite safety testing: industry and regulatory shared learning

A MIST conception: what has been learned from twenty years of human metabolite safety assessment?

PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab

Predicting Circulating Human Metabolites: How Good Are We?

Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase‐1

Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α

The Types of the Swedish Folk Legend by Bengt af Klintberg (review)

The early estimation of circulating drug metabolites in humans

Unique Major Human Metabolites: Why, How, and When to Test for Safety in Animals

A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations

Morningness in Teachers is Related to a Higher Sense of Coherence and Lower Burnout

Population Pharmacokinetic Modeling of Olaratumab, an Anti-PDGFRα Human Monoclonal Antibody, in Patients with Advanced and/or Metastatic Cancer

Identification and Mitigation of Reactive Metabolites of 2‑Aminoimidazole-Containing Microsomal Prostaglandin E Synthase‑1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

A Strategy for the Risk Assessment of Human Genotoxic Metabolites

Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8

Overview of metabolite safety testing from an industry perspective

Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats

Design and Synthesis of a Potent and Selective Triazolone-Based Peroxisome Proliferator-Activated Receptor α Agonist

Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

TYPOLOGICKÁ KLASIFIKACE LIDOVÝCH POHÁDEK A POVĚSTÍ V MEZINÁRODNÍM KONTEXTU

Evaluation in vitro and in animals of a new ^sup 11^C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes

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