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Integrating Cell-Based and Clinical Genome-Wide Studies to Identify Genetic Variants Contributing to Treatment Failure in Neuroblastoma Patients

Clinical pharmacology and therapeutics, 2014-06, Vol.95 (6), p.644-652

2014

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The chemistry of the metabolites of cyclophosphamide

Current pharmaceutical design, 1999-08, Vol.5 (8), p.627

Ludeman, S M

1999

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Assessment of Aldehyde Dehydrogenase in Viable Cells

Blood, 1995-05, Vol.85 (10), p.2742-2746

1995

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Evaluation of an elastin-like polypeptide–doxorubicin conjugate for cancer therapy

Journal of controlled release, 2003-08, Vol.91 (1), p.31-43

2003

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Isolation of Primitive Human Hematopoietic Progenitors on the Basis of Aldehyde Dehydrogenase Activity

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (16), p.9118-9123

1999

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A Structural Basis for a Phosphoramide Mustard-Induced DNA Interstrand Cross-Link at 5'-d(GAC)

Proceedings of the National Academy of Sciences - PNAS, 1995-12, Vol.92 (26), p.12170-12174

1995

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The Partitioning of Phosphoramide Mustard and Its Aziridinium Ions among Alkylation and P−N Bond Hydrolysis Reactions

Journal of medicinal chemistry, 1998-02, Vol.41 (4), p.515-529

1998

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Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide

Cancer chemotherapy and pharmacology, 2000, Vol.45 (4), p.335-344

2000

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Cyclophosphamide resistance in medulloblastoma

Cancer research (Chicago, Ill.), 1992-10, Vol.52 (19), p.5373-5378

1992

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Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

Cancer research (Chicago, Ill.), 1988-08, Vol.48 (15), p.4189-4195

1988

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Comparison of the Protonation of Isophosphoramide Mustard and Phosphoramide Mustard

Journal of medicinal chemistry, 1995-06, Vol.38 (12), p.2166-2175

1995

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Oxime Derivatives of the Intermediary Oncostatic Metabolites of Cyclophosphamide and Ifosfamide: Synthesis and Deuterium Labeling for Applications to Metabolite Quantification

Journal of pharmaceutical sciences, 1995-04, Vol.84 (4), p.393-398

1995

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Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector

Cancer research (Chicago, Ill.), 2001-02, Vol.61 (3), p.864-868

2001

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Carboxyphosphamide: NMR studies of its stability and cell membrane permeability

Drug metabolism and disposition, 1992-03, Vol.20 (2), p.337

1992

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Effect of stereochemistry on the oxidative metabolism of the cyclophosphamide metabolite aldophosphamide

Biochemical pharmacology, 1995-07, Vol.50 (3), p.429-433

1995

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1,3- vs 1,5-Intramolecular Alkylation Reactions in Isophosphoramide and Phosphoramide Mustards

Chemical research in toxicology, 2004-09, Vol.17 (9), p.1217-1226

2004

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Experimental chemotherapy of human medulloblastoma with classical alkylators

Cancer research (Chicago, Ill.), 1986-06, Vol.46 (6), p.2827-2833

1986

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Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity

Cancer research (Chicago, Ill.), 1999-07, Vol.59 (13), p.3059-3063

1999

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Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals

DNA repair, 2007-08, Vol.6 (8), p.1145-1154

2007

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Quantitation of 4-hydroxycyclophosphamide/aldophosphamide in whole blood

Journal of chromatography. B, Biomedical applications, 1995-05, Vol.667 (2), p.247-257

1995

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Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy

Arzneimittel-Forschung, 1994-01, Vol.44 (1), p.84

1994

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Altered metabolism of cyclophosphamide given in a low-dose metronomic manner does not account for eventual resistance

Journal of clinical oncology, 2005-06, Vol.23 (16_suppl), p.3185-3185

2005

Volltextzugriff (PDF)

NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathways

Journal of medicinal chemistry, 1984-04, Vol.27 (4), p.466-485

1984

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Synthesis of reactive metabolite-analogues of cyclophosphamide for comparisons of NMR kinetic parameters and anticancer screening data

Drugs under experimental and clinical research, 1986, Vol.12 (6-7), p.527

1986

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31P NMR studies of the kinetics of bisalkylation by isophosphoramide mustard: comparisons with phosphoramide mustard

Journal of medicinal chemistry, 1989-08, Vol.32 (8), p.1768-1773

1989

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Integrating Cell-Based and Clinical Genome-Wide Studies to Identify Genetic Variants Contributing to Treatment Failure in Neuroblastoma Patients

The chemistry of the metabolites of cyclophosphamide

Assessment of Aldehyde Dehydrogenase in Viable Cells

Evaluation of an elastin-like polypeptide–doxorubicin conjugate for cancer therapy

Isolation of Primitive Human Hematopoietic Progenitors on the Basis of Aldehyde Dehydrogenase Activity

A Structural Basis for a Phosphoramide Mustard-Induced DNA Interstrand Cross-Link at 5'-d(GAC)

The Partitioning of Phosphoramide Mustard and Its Aziridinium Ions among Alkylation and P−N Bond Hydrolysis Reactions

Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide

Cyclophosphamide resistance in medulloblastoma

Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

Comparison of the Protonation of Isophosphoramide Mustard and Phosphoramide Mustard

Oxime Derivatives of the Intermediary Oncostatic Metabolites of Cyclophosphamide and Ifosfamide: Synthesis and Deuterium Labeling for Applications to Metabolite Quantification

Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector

Carboxyphosphamide: NMR studies of its stability and cell membrane permeability

Effect of stereochemistry on the oxidative metabolism of the cyclophosphamide metabolite aldophosphamide

1,3- vs 1,5-Intramolecular Alkylation Reactions in Isophosphoramide and Phosphoramide Mustards

Experimental chemotherapy of human medulloblastoma with classical alkylators

Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity

Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals

Quantitation of 4-hydroxycyclophosphamide/aldophosphamide in whole blood

Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy

Altered metabolism of cyclophosphamide given in a low-dose metronomic manner does not account for eventual resistance

Synthesis of reactive metabolite-analogues of cyclophosphamide for comparisons of NMR kinetic parameters and anticancer screening data

31P NMR studies of the kinetics of bisalkylation by isophosphoramide mustard: comparisons with phosphoramide mustard

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