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Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications

Accounts of chemical research, 2017-07, Vol.50 (7), p.1541-1556

2017

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Applications of γ,δ-Unsaturated Ketones Synthesized by Copper-Catalyzed Cascade Addition of Vinyl Grignard Reagents to Esters

Accounts of chemical research, 2018-10, Vol.51 (10), p.2574-2588

2018

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1,3,5,8-Tetrasubstituted 1,3,4-Benzotriazepin-2-one Scaffolds for β‑Turn Mimicry without Stereogenic Carbon Centers: Synthesis and Conformational Analysis

Journal of organic chemistry, 2023-04, Vol.88 (7), p.4633-4648

2023

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Constrained Dipeptide Surrogates: 5- and 7-Hydroxy Indolizidin-2-one Amino Acid Synthesis from Iodolactonization of Dehydro-2,8-diamino Azelates

Molecules (Basel, Switzerland), 2021-12, Vol.27 (1), p.67

2021

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Peptide-Based Drug Development

Biomedicines, 2022-08, Vol.10 (8), p.2037

Lubell, William D

2022

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Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila

PLoS genetics, 2017-04, Vol.13 (4), p.e1006694-e1006694

2017

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Dynamic Chirality in the Mechanism of Action of Allosteric CD36 Modulators of Macrophage-Driven Inflammation

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11071-11079

2019

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Diversity-Oriented Syntheses of β‑Substituted α‑Amino γ‑Lactam Peptide Mimics with Constrained Backbone and Side Chain Residues

Organic letters, 2018-10, Vol.20 (19), p.6126-6129

2018

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Stereo- and Regiochemical Transannular Cyclization of a Common Hexahydro‑1H‑azonine to Afford Three Different Indolizidinone Dipeptide Mimetics

Journal of organic chemistry, 2020-02, Vol.85 (3), p.1340-1351

2020

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6‑Hydroxymethyl Indolizidin-2-one Amino Acid Synthesis, Conformational Analysis, and Biomedical Application as Dipeptide Surrogates in Prostaglandin‑F2α Modulators

Organic letters, 2021-07, Vol.23 (13), p.5192-5196

2021

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Secondary Structure Stabilization of Macrocyclic Antimicrobial Peptides via Cross-Link Swapping

Journal of medicinal chemistry, 2024-05, Vol.67 (11), p.8693-8707

2024

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Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics

Organic & biomolecular chemistry, 2014-07, Vol.12 (28), p.552-57

2014

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Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates

Organic letters, 2015-12, Vol.17 (24), p.6046-6049

2015

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A critical role of interleukin-1 in preterm labor

Cytokine & growth factor reviews, 2016-04, Vol.28, p.37-51

2016

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Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides

Organic & biomolecular chemistry, 2022-10, Vol.2 (4), p.7963-7971

2022

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Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9838-9859

2017

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N‑Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis

Organic letters, 2012-09, Vol.14 (17), p.4552-4555

2012

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Azopeptides: Synthesis and Pericyclic Chemistry

Organic letters, 2015-11, Vol.17 (21), p.5400-5403

2015

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5‑Substituted N‑Aminoimidazolone Peptide Mimic Synthesis by Organocatalyzed Reactions of Azopeptides and Use in the Analysis of Biologically Active Backbone and Side-Chain Topology

Organic letters, 2021-05, Vol.23 (9), p.3491-3495

2021

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Synthesis of 5- and 7-hydroxy indolizidin-2-one prostaglandin-F 2α modulators and activity on myometrial contractility towards development of agents for delaying preterm birth

Journal of peptide science, 2023-03, Vol.29 (3), p.e3455

2023

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Synthesis of 5‐ and 7‐hydroxy indolizidin‐2‐one prostaglandin‐F2α modulators and activity on myometrial contractility towards development of agents for delaying preterm birth

Journal of peptide science, 2023-03, Vol.29 (3), p.e3455-n/a

2023

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Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers

Proceedings of the National Academy of Sciences - PNAS, 2022-12, Vol.119 (49), p.e2210766119

2022

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Rho Signaling Pathway Targeted to Promote Spinal Cord Repair

The Journal of neuroscience, 2002-08, Vol.22 (15), p.6570-6577

2002

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Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics

Journal of medicinal chemistry, 2023-10, Vol.66 (20), p.14241-14262

2023

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Isolated α-turn and incipient γ-helix

Chemical science (Cambridge), 2019-07, Vol.1 (28), p.698-6914

2019

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Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications

Applications of γ,δ-Unsaturated Ketones Synthesized by Copper-Catalyzed Cascade Addition of Vinyl Grignard Reagents to Esters

1,3,5,8-Tetrasubstituted 1,3,4-Benzotriazepin-2-one Scaffolds for β‑Turn Mimicry without Stereogenic Carbon Centers: Synthesis and Conformational Analysis

Constrained Dipeptide Surrogates: 5- and 7-Hydroxy Indolizidin-2-one Amino Acid Synthesis from Iodolactonization of Dehydro-2,8-diamino Azelates

Peptide-Based Drug Development

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila

Dynamic Chirality in the Mechanism of Action of Allosteric CD36 Modulators of Macrophage-Driven Inflammation

Diversity-Oriented Syntheses of β‑Substituted α‑Amino γ‑Lactam Peptide Mimics with Constrained Backbone and Side Chain Residues

Stereo- and Regiochemical Transannular Cyclization of a Common Hexahydro‑1H‑azonine to Afford Three Different Indolizidinone Dipeptide Mimetics

6‑Hydroxymethyl Indolizidin-2-one Amino Acid Synthesis, Conformational Analysis, and Biomedical Application as Dipeptide Surrogates in Prostaglandin‑F2α Modulators

Secondary Structure Stabilization of Macrocyclic Antimicrobial Peptides via Cross-Link Swapping

Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics

Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates

A critical role of interleukin-1 in preterm labor

Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides

Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics

N‑Amino-imidazolin-2-one Peptide Mimic Synthesis and Conformational Analysis

Azopeptides: Synthesis and Pericyclic Chemistry

5‑Substituted N‑Aminoimidazolone Peptide Mimic Synthesis by Organocatalyzed Reactions of Azopeptides and Use in the Analysis of Biologically Active Backbone and Side-Chain Topology

Synthesis of 5- and 7-hydroxy indolizidin-2-one prostaglandin-F 2α modulators and activity on myometrial contractility towards development of agents for delaying preterm birth

Synthesis of 5‐ and 7‐hydroxy indolizidin‐2‐one prostaglandin‐F2α modulators and activity on myometrial contractility towards development of agents for delaying preterm birth

Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers

Rho Signaling Pathway Targeted to Promote Spinal Cord Repair

Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics

Isolated α-turn and incipient γ-helix

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