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Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

Cell, 2012-03, Vol.149 (1), p.232-244

2012

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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Nature (London), 2014-04, Vol.508 (7497), p.541-545

2014

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A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways

Journal of controlled release, 2018-01, Vol.269, p.405-422

2018

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The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

Nature reviews. Cancer, 2016-07, Vol.16 (7), p.463

2016

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ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1

Molecular cell, 2015-10, Vol.60 (1), p.35-46

2015

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Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

Molecular cell, 2011-04, Vol.42 (2), p.147-159

2011

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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Nature, 2006-03, Vol.440 (7083), p.528-534

2006

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The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation

Cell reports (Cambridge), 2015-04, Vol.11 (1), p.111-124

2015

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MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways

Scientific reports, 2017-04, Vol.7 (1), p.45915-45915, Article 45915

2017

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A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

Cancer cell, 2011-08, Vol.20 (2), p.214-228

2011

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Pin1‐Targeted Therapy for Systemic Lupus Erythematosus

Arthritis & rheumatology (Hoboken, N.J.), 2016-10, Vol.68 (10), p.2503-2513

2016

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Targeting PIN1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis

Cancer science, 2019-08, Vol.110 (8), p.2442-2455

2019

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Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (33), p.12016-12021

2008

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Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma

Oncotarget, 2017-05, Vol.8 (18), p.29771-29784

2017

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Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

Trends in biochemical sciences (Amsterdam. Regular ed.), 2011-10, Vol.36 (10), p.501-514

2011

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"Tau immunotherapy: Hopes and hindrances"

Human vaccines & immunotherapeutics, 2018-02, Vol.14 (2), p.277-284

2018

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Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

Cell reports (Cambridge), 2015-10, Vol.13 (4), p.812-828

2015

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Prolyl cis-trans isomerization as a molecular timer

Nature chemical biology, 2007-10, Vol.3 (10), p.619-629

2007

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Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

Nature (London), 2015-07, Vol.523 (7561), p.431-436

2015

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Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Nature communications, 2018-08, Vol.9 (1), p.3069-17, Article 3069

2018

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Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

Biochimica et biophysica acta, 2015-10, Vol.1850 (10), p.2069-2076

2015

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Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite

Acta biomaterialia, 2019-03, Vol.86, p.395-405

2019

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Structural Basis for High-Affinity Peptide Inhibition of Human Pin1

ACS chemical biology, 2007-05, Vol.2 (5), p.320-328

2007

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Association of cancer and Alzheimer's disease risk in a national cohort of veterans

Alzheimer's & dementia, 2017-12, Vol.13 (12), p.1364-1370

2017

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The F-box Protein FBX4 Targets PIN2/TRF1 for Ubiquitin-mediated Degradation and Regulates Telomere Maintenance

The Journal of biological chemistry, 2006-01, Vol.281 (2), p.759-768

2006

Volltextzugriff (PDF)

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Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways

The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1

Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation

MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

Pin1‐Targeted Therapy for Systemic Lupus Erythematosus

Targeting PIN1 exerts potent antitumor activity in pancreatic ductal carcinoma via inhibiting tumor metastasis

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration

Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

"Tau immunotherapy: Hopes and hindrances"

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

Prolyl cis-trans isomerization as a molecular timer

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells

Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite

Structural Basis for High-Affinity Peptide Inhibition of Human Pin1

Association of cancer and Alzheimer's disease risk in a national cohort of veterans

The F-box Protein FBX4 Targets PIN2/TRF1 for Ubiquitin-mediated Degradation and Regulates Telomere Maintenance

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