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Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1151-1156

2008

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Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

The EMBO journal, 1998-10, Vol.17 (20), p.5896-5904

1998

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Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.1915-1926

2001

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Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1998-12, Vol.41 (27), p.5457-5465

1998

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Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2373-2382

1999

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Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5567-5572

2007

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In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1433

1997

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In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase

The Journal of pharmacology and experimental therapeutics, 1998-07, Vol.286 (1), p.569

1998

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2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3276-3292

1998

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Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2296-2303

1997

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Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 1997-09, Vol.7 (18), p.2415-2420

1997

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377

1998

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Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor

The Journal of pharmacology and experimental therapeutics, 1997-06, Vol.281 (3), p.1446

1997

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Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships among N- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.413-426

1997

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INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR

Life sciences (1973), 1998, Vol.62 (2), p.143-150

1998

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Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as Selective Inhibitors of pp60 c -src

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3134-3147

2000

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Design of Peptidomimetics That Inhibit the Association of Phosphatidylinositol 3-Kinase with Platelet-Derived Growth Factor-β Receptor and Possess Cellular Activity

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4329-4342

1998

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Subclasses of angiotensin II binding sites and their functional significance

Molecular pharmacology, 1990-09, Vol.38 (3), p.370-377

1990

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Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists

Journal of medicinal chemistry, 1993-06, Vol.36 (12), p.1735-1745

1993

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Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8 H -pyrido[2,3- d ]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4365-4377

1998

Volltextzugriff (PDF)

Pyrazole inhibitors of ΗΜΓ-CoA reductase : An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (20), p.5567-5572

2007

Volltextzugriff (PDF)

Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-β receptor

Bioorganic & medicinal chemistry, 1995-09, Vol.3 (9), p.1263-1272

1995

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The syntheses and binding affinities of tools for the study of angiotensin AT2 receptors

Bioorganic & medicinal chemistry letters, 1993-05, Vol.3 (5), p.905-908

1993

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The syntheses and binding affinities of tools for the study of angiotensin AT 2 receptors

Bioorganic & medicinal chemistry letters, 1993, Vol.3 (5), p.905-908

1993

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Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure−Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity

Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3R,5R)-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia

Structure−Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor

Structure−Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor

Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor

In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase

2-Substituted Aminopyrido[2,3-d]pyrimidin-7(8H)-ones. Structure−Activity Relationships Against Selected Tyrosine Kinases and in Vitro and in Vivo Anticancer Activity

Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

Discovery and structure-activity studies of a novel series of pyrido[2,3- d]pyrimidine tyrosine kinase inhibitors

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8H-pyrido[2,3-d]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor

Tyrosine Kinase Inhibitors. 6. Structure−Activity Relationships among N- and 3-Substituted 2,2‘-Diselenobis(1H-indoles) for Inhibition of Protein Tyrosine Kinases and Comparative in Vitro and in Vivo Studies against Selected Sulfur Congeners

INHIBITION OF FGF-1 RECEPTOR TYROSINE KINASE ACTIVITY BY PD 161570, A NEW PROTEIN-TYROSINE KINASE INHIBITOR

Synthesis and Structure−Activity Relationships of 7-Substituted 3-(2,6-Dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as Selective Inhibitors of pp60 c -src

Design of Peptidomimetics That Inhibit the Association of Phosphatidylinositol 3-Kinase with Platelet-Derived Growth Factor-β Receptor and Possess Cellular Activity

Subclasses of angiotensin II binding sites and their functional significance

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists

Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8 H -pyrido[2,3- d ]pyrimidines: Identification of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors

Pyrazole inhibitors of ΗΜΓ-CoA reductase : An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-β receptor

The syntheses and binding affinities of tools for the study of angiotensin AT2 receptors

The syntheses and binding affinities of tools for the study of angiotensin AT 2 receptors

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