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Identification and characterization of Cardiac Glycosides as senolytic compounds

Nature communications, 2019-10, Vol.10 (1), p.4731-4731, Article 4731

2019

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A Positive Allosteric Modulator of the Serotonin 5‑HT2C Receptor for Obesity

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9575-9584

2017

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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives

Molecules (Basel, Switzerland), 2024-06, Vol.29 (11), p.2543

2024

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Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin

Scientific reports, 2018-10, Vol.8 (1), p.15381-11, Article 15381

2018

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A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

Pharmaceutics, 2020-03, Vol.12 (3), p.284

2020

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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

European journal of medicinal chemistry, 2012, Vol.47 (1), p.175-185

2012

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High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries

SLAS discovery, 2024-04, Vol.29 (3), p.100149-100149, Article 100149

2024

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A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

Journal for immunotherapy of cancer, 2022-05, Vol.10 (5), p.e004592

2022

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Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M

Biomedicine & pharmacotherapy, 2020-01, Vol.121, p.109601, Article 109601

2020

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Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.6085-6094

2008

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Editorial: Novel Approaches to the Neuropharmacology of Mood Disorders

Frontiers in pharmacology, 2019-05, Vol.10, p.589-589

2019

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Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1773-1778

2009

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5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines

PloS one, 2019-01, Vol.14 (1), p.e0209804-e0209804

2019

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Structure‐Based Virtual Screening for Dopamine D 2 Receptor Ligands as Potential Antipsychotics

ChemMedChem, 2016-04, Vol.11 (7), p.718-729

2016

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A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade

Thrombosis and haemostasis, 2020-02, Vol.120 (2), p.262-276

2020

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Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2‑Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

Journal of medicinal chemistry, 2017-04, Vol.60 (8), p.3372-3382

2017

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Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents

Biomedicine & pharmacotherapy, 2024-04, Vol.173, p.116345-116345, Article 116345

2024

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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

EBioMedicine, 2019-07, Vol.45, p.588-605

2019

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Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.890-912

2023

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Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug

European journal of pharmacology, 2021-09, Vol.906, p.174276, Article 174276

2021

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Discovery of V‑0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide‑1 Receptor toward Oral Treatment for “Diabesity”

Journal of medicinal chemistry, 2022-04, Vol.65 (7), p.5449-5461

2022

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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs

European journal of medicinal chemistry, 2019-10, Vol.180, p.673-689

2019

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Exploring Biginelli-based scaffolds as A 2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents

Biomedicine & pharmacotherapy, 2024-04, Vol.173, p.116345

2024

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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder

ACS chemical neuroscience, 2021-04, Vol.12 (8), p.1313-1327

2021

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2‑(Fluoromethoxy)-4′‑(S‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson’s Disease

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.12256-12272

2022

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Identification and characterization of Cardiac Glycosides as senolytic compounds

A Positive Allosteric Modulator of the Serotonin 5‑HT2C Receptor for Obesity

2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives

Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries

A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M

Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives as Potential Antipsychotics

Editorial: Novel Approaches to the Neuropharmacology of Mood Disorders

Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands

5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines

Structure‐Based Virtual Screening for Dopamine D 2 Receptor Ligands as Potential Antipsychotics

A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade

Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2‑Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists

Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug

Discovery of V‑0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide‑1 Receptor toward Oral Treatment for “Diabesity”

Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs

Exploring Biginelli-based scaffolds as A 2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents

Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder

2‑(Fluoromethoxy)-4′‑(S‑methanesulfonimidoyl)-1,1′-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson’s Disease

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