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Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib

Clinical pharmacokinetics, 2019-09, Vol.58 (9), p.1131-1147

2019

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Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4466-4480

2009

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Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood-Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery

Pharmaceutics, 2019-11, Vol.11 (11), p.595

2019

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3275-3280

2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3270-3274

2015

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Design, synthesis and evaluation of MCH receptor 1 antagonists—Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3264-3269

2015

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Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule

European journal of pharmaceutics and biopharmaceutics, 2019-03, Vol.136, p.221-230

2019

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8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Journal of medicinal chemistry, 2007-12, Vol.50 (26), p.6450-6453

2007

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Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes

Journal of pharmaceutical sciences, 2021-01, Vol.110 (1), p.376-387

2021

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Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs

The AAPS journal, 2020-10, Vol.22 (6), Article 133

2020

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Elucidation of phase I and phase II metabolic pathways of rhein: species differences and their potential relevance

Drug metabolism and disposition, 1997-04, Vol.25 (4), p.442

1997

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3,5-Dihydro-imidazo[4,5- d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3158-3162

2008

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P3‐025: Lowering peripheral Aß is sufficient to reverse cognitive impairment in Tg2576 mice

Alzheimer's & dementia, 2011-07, Vol.7 (4S_Part_15), p.S523-S523

2011

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Lowering peripheral Aß is sufficient to reverse cognitive impairment in Tg2576 mice

Alzheimer's & dementia, 2011-07, Vol.7 (4), p.S523-S523

2011

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Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (4), p.1410-1414

2010

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Discovery of olodaterol, a novel inhaled β 2-adrenoceptor agonist with a 24 h bronchodilatory efficacy

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (4), p.1410-1414

2010

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Discovery of olodaterol, a novel inhaled β2-drenoceptor agonist with a 24 h bronchodilatory efficacy

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (4), p.1410-1414

2010

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FD-FD GSM technique for the CAD and optimization of combline

IEEE MTT-S International Microwave Symposium digest, 2001, Vol.2, p.1253-1256

2001

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Advanced FD-TD Techniques for the CAD of 3D Microwave Components

Electromagnetics, 2003-01, Vol.23 (2), p.153-168

2003

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Discovery of olodaterol, a novel inhaled beta2-adrenoceptor agonist with a 24 h bronchodilatory efficacy

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (4), p.1410-1414

2010

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Sequence verification of oligodeoxynucleotides and oligophosphorothioates using electrospray ionization (tandem) mass spectrometry

Rapid communications in mass spectrometry, 1998-04, Vol.12 (7), p.389-397

1998

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Structure elucidation of yersiniabactin, a siderophore from highly virulent Yersinia strains

Liebigs Annalen, 1995-10, Vol.1995 (10), p.1727-1733

1995

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Locally conformed subgrid FD-FD technique for the analysis of 3D waveguide structures with curved metallic objects

1999 IEEE MTT-S International Microwave Symposium Digest (Cat. No.99CH36282), 1999, Vol.3, p.1277-1280 vol.3

1999

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IEEE_Xplore

3D subgrid technique for the finite difference method in the frequency domain

1998 IEEE MTT-S International Microwave Symposium Digest (Cat. No.98CH36192), 1998, Vol.3, p.1739-1742 vol.3

1998

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IEEE_Xplore

Advanced Subgrid FD Technique for Modeling Waveguide Structures with Curved Conducting and Dielectric Boundaries

2000 30th European Microwave Conference, 2000, p.1-4

2000

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Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib

Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)

Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood-Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery

Design, synthesis and evaluation of MCH receptor 1 antagonists—Part III: Discovery of pre-clinical development candidate BI 186908

Design, synthesis and evaluation of MCH receptor 1 antagonists—Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition

Design, synthesis and evaluation of MCH receptor 1 antagonists—Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414

Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule

8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes

Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes

Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs

Elucidation of phase I and phase II metabolic pathways of rhein: species differences and their potential relevance

3,5-Dihydro-imidazo[4,5- d]pyridazin-4-ones: A class of potent DPP-4 inhibitors

P3‐025: Lowering peripheral Aß is sufficient to reverse cognitive impairment in Tg2576 mice

Lowering peripheral Aß is sufficient to reverse cognitive impairment in Tg2576 mice

Discovery of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy

Discovery of olodaterol, a novel inhaled β 2-adrenoceptor agonist with a 24 h bronchodilatory efficacy

Discovery of olodaterol, a novel inhaled β2-drenoceptor agonist with a 24 h bronchodilatory efficacy

FD-FD GSM technique for the CAD and optimization of combline

Advanced FD-TD Techniques for the CAD of 3D Microwave Components

Discovery of olodaterol, a novel inhaled beta2-adrenoceptor agonist with a 24 h bronchodilatory efficacy

Sequence verification of oligodeoxynucleotides and oligophosphorothioates using electrospray ionization (tandem) mass spectrometry

Structure elucidation of yersiniabactin, a siderophore from highly virulent Yersinia strains

Locally conformed subgrid FD-FD technique for the analysis of 3D waveguide structures with curved metallic objects

3D subgrid technique for the finite difference method in the frequency domain

Advanced Subgrid FD Technique for Modeling Waveguide Structures with Curved Conducting and Dielectric Boundaries

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