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Synthesis of thrombin-inhibiting heparin mimetics without side effects

Nature (London), 1999-04, Vol.398 (6726), p.417-422

1999

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Human umbilical vein endothelial cells express high affinity receptors for factor Xa

Journal of cellular physiology, 1997-07, Vol.172 (1), p.36-43

1997

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Heparin-derived oligosaccharides: Affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells

Journal of cellular physiology, 1989-09, Vol.140 (3), p.538-548

1989

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Synthesis and Pharmacological Properties of a Close Analogue of an Antithrombotic Pentasaccharide (SR 90107A/ORG 31540)

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1600-1607

1997

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STRUCTURAL STUDIES ON A BIOLOGICALLY ACTIVE HEXASACCHARIDE OBTAINED FROM HEPARIN

Annals of the New York Academy of Sciences, 1981-06, Vol.370 (1), p.644-649

1981

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Introducing a C-interglycosidic bond in a biologically active pentasaccharide hardly affects its biological properties

Bioorganic & medicinal chemistry, 1998-09, Vol.6 (9), p.1509-1516

1998

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Comparative inhibition of extrinsic and intrinsic thrombin generation by standard heparin, a low molecular weight heparin and the synthetic ATIII-binding pentasaccharide

Thrombosis and haemostasis, 1993, Vol.69 (2), p.152

1993

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Synthesis and biological activity of a new anti-factor Xa pentasaccharide with a C-interglycosidic bond

Bioorganic & medicinal chemistry letters, 1997-06, Vol.7 (12), p.1507-1510

1997

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Selectively O-acylated glycosaminoglycan derivatives

Carbohydrate research, 1992-12, Vol.236, p.107-119

1992

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Studies on the structural requirements of heparin for the catalysis of thrombin inhibition by heparin cofactor II

Biochimica et biophysica acta, 1988-08, Vol.966 (2), p.188-195

1988

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O-Acylated heparin derivatives with low anticoagulant activity decrease proliferation and increase α-smooth muscle actin expression in cultured arterial smooth muscle cells

European journal of pharmacology, 1992-08, Vol.219 (2), p.225-233

1992

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Interaction of heparin and antithrombin III: the role of O-sulfate groups

European journal of biochemistry, 1988-10, Vol.176 (3), p.637-640

1988

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Contribution of 3-O- and 6-O-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III

Biochemistry (Easton), 1987-10, Vol.26 (20), p.6454-6461

1987

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Antithrombin-mediated inhibition of factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin

Thrombosis and haemostasis, 1996-07, Vol.76 (1), p.5

1996

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Chemical synthesis of glycosaminoglycans : new approaches to antithrombotic drugs

Nature (London), 1991-04, Vol.350 (6319), p.30-33

1991

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ChemInform Abstract: Synthetic Oligosaccharides Having Various Functional Domains: Potent and Potentially Safe Heparin Mimetics

ChemInform, 1999-08, Vol.30 (32), p.no-no

1999

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Contribution of 3-0- and 6-0-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III

Biochemistry (Easton), 1987, Vol.26 (20), p.6454-6461

1987

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Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect

Journal of medicinal chemistry, 1993-11, Vol.36 (23), p.3546-3555

1993

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DETERMINATION OF THE ANTI-FACTOR Xa ACTIVITY OF THE SYNTHETIC PENTASACCHARIDE SR 90107A/ORG 31540 AND OF TWO STRUCTURAL ANALOGUES

Thrombosis research, 1997, Vol.85 (1), p.67-75

1997

Volltextzugriff (PDF)

Structural Determinants of the Capacity of Heparin to Inhibit the Proliferation of Vascular Smooth Muscle Cells. II. Evidence for a Pentasaccharide Sequence That Contains a 3-O-Sulfate Group

The Journal of cell biology, 1986-05, Vol.102 (5), p.1979-1984

1986

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Binding of heparin fractions to von Willebrand factor: effect of molecular weight and affinity for antithrombin III

Thrombosis and haemostasis, 1994-01, Vol.71 (1), p.141

1994

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Antithrombin III Affinity Dependence on the Anticoagulant, Antiprotease, and Tissue Factor Pathway Inhibitor Actions of Heparins

Seminars in thrombosis and hemostasis, 1995-01, Vol.21 (2), p.193-200

1995

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Intravenous antithrombotic activity of a synthetic heparin pentasaccharide in a human serum induced stasis thrombosis model

Thrombosis research, 1986-07, Vol.43 (2), p.243-248

1986

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Interaction of heparin and antithrombin III

European journal of biochemistry, 1988-10, Vol.176 (3), p.637-640

1988

Volltextzugriff (PDF)

Oral Administration of Low Molecular Weight Heparin Fractions in Rabbits

Seminars in thrombosis and hemostasis, 1985-07, Vol.11 (3), p.323-325

1985

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Synthesis of thrombin-inhibiting heparin mimetics without side effects

Human umbilical vein endothelial cells express high affinity receptors for factor Xa

Heparin-derived oligosaccharides: Affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells

Synthesis and Pharmacological Properties of a Close Analogue of an Antithrombotic Pentasaccharide (SR 90107A/ORG 31540)

STRUCTURAL STUDIES ON A BIOLOGICALLY ACTIVE HEXASACCHARIDE OBTAINED FROM HEPARIN

Introducing a C-interglycosidic bond in a biologically active pentasaccharide hardly affects its biological properties

Comparative inhibition of extrinsic and intrinsic thrombin generation by standard heparin, a low molecular weight heparin and the synthetic ATIII-binding pentasaccharide

Synthesis and biological activity of a new anti-factor Xa pentasaccharide with a C-interglycosidic bond

Selectively O-acylated glycosaminoglycan derivatives

Studies on the structural requirements of heparin for the catalysis of thrombin inhibition by heparin cofactor II

O-Acylated heparin derivatives with low anticoagulant activity decrease proliferation and increase α-smooth muscle actin expression in cultured arterial smooth muscle cells

Interaction of heparin and antithrombin III: the role of O-sulfate groups

Contribution of 3-O- and 6-O-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III

Antithrombin-mediated inhibition of factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin

Chemical synthesis of glycosaminoglycans : new approaches to antithrombotic drugs

ChemInform Abstract: Synthetic Oligosaccharides Having Various Functional Domains: Potent and Potentially Safe Heparin Mimetics

Contribution of 3-0- and 6-0-sulfated glucosamine residues in the heparin-induced conformational change in antithrombin III

Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect

DETERMINATION OF THE ANTI-FACTOR Xa ACTIVITY OF THE SYNTHETIC PENTASACCHARIDE SR 90107A/ORG 31540 AND OF TWO STRUCTURAL ANALOGUES

Structural Determinants of the Capacity of Heparin to Inhibit the Proliferation of Vascular Smooth Muscle Cells. II. Evidence for a Pentasaccharide Sequence That Contains a 3-O-Sulfate Group

Binding of heparin fractions to von Willebrand factor: effect of molecular weight and affinity for antithrombin III

Antithrombin III Affinity Dependence on the Anticoagulant, Antiprotease, and Tissue Factor Pathway Inhibitor Actions of Heparins

Intravenous antithrombotic activity of a synthetic heparin pentasaccharide in a human serum induced stasis thrombosis model

Interaction of heparin and antithrombin III

Oral Administration of Low Molecular Weight Heparin Fractions in Rabbits

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