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Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

Neuron (Cambridge, Mass.), 2019-07, Vol.103 (2), p.250-265.e8

2019

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B-lymphocyte-mediated delayed cognitive impairment following stroke

The Journal of neuroscience, 2015-02, Vol.35 (5), p.2133-2145

2015

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

The Journal of clinical investigation, 2010-05, Vol.120 (5), p.1774-1785

2010

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Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors

The Journal of neuroscience, 2011-10, Vol.31 (40), p.14051-14066

2011

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A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

The Journal of neuroscience, 2013-11, Vol.33 (48), p.18712-18727

2013

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Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage

Neurobiology of disease, 2022-01, Vol.162, p.105563-105563, Article 105563

2022

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Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts

Neurobiology of disease, 2018-04, Vol.112, p.63-78

2018

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Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies

Scientific reports, 2020-11, Vol.10 (1), p.20322-17, Article 20322

2020

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Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease

Frontiers in neuroscience, 2019-07, Vol.13, p.533-533

2019

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A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome

The Journal of neuroscience, 2012-02, Vol.32 (5), p.1803-1810

2012

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Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning

Journal of neuroinflammation, 2023-02, Vol.20 (1), p.48-48, Article 48

2023

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Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons

Neurobiology of disease, 2018-05, Vol.113, p.45-58

2018

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Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

Disease models & mechanisms, 2020-11, Vol.13 (11)

2020

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Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury

The Journal of neuroscience, 2013-01, Vol.33 (2), p.397-410

2013

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Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

Nature communications, 2019-04, Vol.10 (1), p.1745-1745, Article 1745

2019

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A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice

Disease models & mechanisms, 2024-06, Vol.17 (6)

2024

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A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Disease models & mechanisms, 2017-07, Vol.10 (7), p.837-845

2017

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Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

Neurobiology of disease, 2015-01, Vol.73, p.36-48

2015

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Modulation of p75NTR on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model

International journal of molecular sciences, 2021-01, Vol.22 (2), p.829

2021

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Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

Nature reviews. Drug discovery, 2013-07, Vol.12 (7), p.507-525

2013

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Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

Acta neuropathologica communications, 2020-09, Vol.8 (1), p.156-23, Article 156

2020

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Open drug discovery in Alzheimer's disease

Alzheimer's & dementia : translational research & clinical interventions, 2023-04, Vol.9 (2), p.e12394-n/a

2023

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The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis

BMC neuroscience, 2010-10, Vol.11 (1), p.136-136, Article 136

2010

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ProNGF Induces p75-Mediated Death of Oligodendrocytes following Spinal Cord Injury

Neuron (Cambridge, Mass.), 2002-10, Vol.36 (3), p.375-386

2002

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Senolytic therapy for Alzheimer’s disease

Nature medicine, 2023-10, Vol.29 (10), p.2409-2411

2023

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Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

B-lymphocyte-mediated delayed cognitive impairment following stroke

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease

Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts

Small molecule modulation of the p75 neurotrophin receptor inhibits multiple amyloid beta-induced tau pathologies

Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease

A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome

Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning

Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons

Restoration of motor learning in a mouse model of Rett syndrome following long-term treatment with a novel small-molecule activator of TrkB

Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

Modulation of p75NTR on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

Open drug discovery in Alzheimer's disease

The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis

ProNGF Induces p75-Mediated Death of Oligodendrocytes following Spinal Cord Injury

Senolytic therapy for Alzheimer’s disease

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