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Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy

Science (American Association for the Advancement of Science), 2001-12, Vol.294 (5550), p.2368-2371

2001

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Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

Oncogene, 1999-04, Vol.18 (15), p.2507-2517

1999

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Mammalian Eukaryotic Initiation Factor 2α Kinases Functionally Substitute for GCN2 Protein Kinase in the GCN4 Translational Control Mechanism of Yeast

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (10), p.4616-4620

1993

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An Erythroid-Specific, Developmental-Stage-Independent Enhancer Far Upstream of the Human "β -Like Globin" Genes

Proceedings of the National Academy of Sciences - PNAS, 1989-04, Vol.86 (8), p.2554-2558

1989

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The ``β -Like-Globin'' Gene Domain in Human Erythroid Cells

Proceedings of the National Academy of Sciences - PNAS, 1985-10, Vol.82 (19), p.6384-6388

1985

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Cloning of the cDNA of the Heme-Regulated Eukaryotic Initiation Factor 2α (eIF-2α) Kinase of Rabbit Reticulocytes: Homology to Yeast GCN2 Protein Kinase and Human Double-Stranded-RNA-Dependent eIF-2α Kinase

Proceedings of the National Academy of Sciences - PNAS, 1991-09, Vol.88 (17), p.7729-7733

1991

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Mutagenesis of retroviral vectors transducing human beta‐globin gene and beta‐globin locus control region derivatives results in stable transmission of an active transcriptional structure

The EMBO journal, 1994-07, Vol.13 (13), p.3065-3076

1994

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Erythroid expression of the heme-regulated eIF-2 alpha kinase

Molecular and Cellular Biology, 1994-06, Vol.14 (6), p.3906-3914

1994

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Effects of hemin and porphyrin compounds on intersubunit disulfide formation of heme-regulated eIF-2 alpha kinase and the regulation of protein synthesis in reticulocyte lysates

The Journal of biological chemistry, 1992-10, Vol.267 (28), p.20519-20524

1992

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Disulfide Bond Formation in the Regulation of eIF-2 α Kinase by Heme

The Journal of biological chemistry, 1989-06, Vol.264 (16), p.9559-9564

1989

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Regulation of protein synthesis by heme-regulated eIF-2α kinase

Trends in Biochemical Sciences, 1995-03, Vol.20 (3), p.105-108

1995

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Detection of Activated Double-Stranded RNA-Dependent Protein Kinase in 3T3-F442A Cells

Proceedings of the National Academy of Sciences - PNAS, 1988-03, Vol.85 (5), p.1427-1431

1988

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Mapping of DNase I-Hypersensitive Sites in the Upstream DNA of Human Embryonic ε -globin Gene in K562 Leukemia Cells

Proceedings of the National Academy of Sciences - PNAS, 1984-05, Vol.81 (9), p.2718-2722

1984

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Role of reversing factor in the inhibition of protein synthesis initiation by oxidized glutathione

The Journal of biological chemistry, 1988-10, Vol.263 (30), p.15652-15656

1988

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Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells

The Journal of biological chemistry, 1984-12, Vol.259 (23), p.14736-14742

1984

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Retroviral Transfer of a Human β-Globin/δ-Globin Hybrid Gene Linked to β Locus Control Region Hypersensitive Site 2 Aimed at the Gene Therapy of Sickle Cell Disease

Proceedings of the National Academy of Sciences - PNAS, 1995-03, Vol.92 (7), p.3014-3018

1995

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The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2

The Journal of biological chemistry, 1984-06, Vol.259 (11), p.6708-6711

1984

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Recycling and Phosphorylation of Eukaryotic Initiation Factor 2 on 60S Subunits of 80S Initiation Complexes and Polysomes

Proceedings of the National Academy of Sciences - PNAS, 1992-12, Vol.89 (24), p.12063-12067

1992

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Preselection of Retrovirally Transduced Bone Marrow Avoids Subsequent Stem Cell Gene Silencing and Age-Dependent Extinction of Expression of Human β -Globin in Engrafted Mice

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5411-5415

2000

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Tissue distribution and immunoreactivity of heme-regulated eIF-2α kinase determined by monoclonal antibodies

Biochemistry (Easton), 1991-03, Vol.30 (9), p.2555-2562

1991

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Regulation of heme-regulated eIF-2α kinase and its expression in erythroid cells

Biochimie, 1994, Vol.76 (8), p.761-769

1994

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Effect of Phosphorylation of the α -Subunit of Eukaryotic Initiation Factor 2 on the Function of Reversing Factor in the Initiation of Protein Synthesis

Proceedings of the National Academy of Sciences - PNAS, 1983-05, Vol.80 (9), p.2559-2563

1983

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Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases

Proceedings of the National Academy of Sciences - PNAS, 1991-01, Vol.88 (2), p.315-319

1991

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Hemin Inhibits Internalization of Transferrin by Reticulocytes and Promotes Phosphorylation of the Membrane Transferrin Receptor

Proceedings of the National Academy of Sciences - PNAS, 1985-08, Vol.82 (15), p.5170-5174

1985

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Relationship between Phosphorylation and Activity of Heme-Regulated Eukaryotic Initiation Factor 2α Kinase

Proceedings of the National Academy of Sciences - PNAS, 1981-02, Vol.78 (2), p.866-870

1981

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Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

Mammalian Eukaryotic Initiation Factor 2α Kinases Functionally Substitute for GCN2 Protein Kinase in the GCN4 Translational Control Mechanism of Yeast

An Erythroid-Specific, Developmental-Stage-Independent Enhancer Far Upstream of the Human "β -Like Globin" Genes

The ``β -Like-Globin'' Gene Domain in Human Erythroid Cells

Cloning of the cDNA of the Heme-Regulated Eukaryotic Initiation Factor 2α (eIF-2α) Kinase of Rabbit Reticulocytes: Homology to Yeast GCN2 Protein Kinase and Human Double-Stranded-RNA-Dependent eIF-2α Kinase

Mutagenesis of retroviral vectors transducing human beta‐globin gene and beta‐globin locus control region derivatives results in stable transmission of an active transcriptional structure

Erythroid expression of the heme-regulated eIF-2 alpha kinase

Effects of hemin and porphyrin compounds on intersubunit disulfide formation of heme-regulated eIF-2 alpha kinase and the regulation of protein synthesis in reticulocyte lysates

Disulfide Bond Formation in the Regulation of eIF-2 α Kinase by Heme

Regulation of protein synthesis by heme-regulated eIF-2α kinase

Detection of Activated Double-Stranded RNA-Dependent Protein Kinase in 3T3-F442A Cells

Mapping of DNase I-Hypersensitive Sites in the Upstream DNA of Human Embryonic ε -globin Gene in K562 Leukemia Cells

Role of reversing factor in the inhibition of protein synthesis initiation by oxidized glutathione

Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells

Retroviral Transfer of a Human β-Globin/δ-Globin Hybrid Gene Linked to β Locus Control Region Hypersensitive Site 2 Aimed at the Gene Therapy of Sickle Cell Disease

The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2

Recycling and Phosphorylation of Eukaryotic Initiation Factor 2 on 60S Subunits of 80S Initiation Complexes and Polysomes

Preselection of Retrovirally Transduced Bone Marrow Avoids Subsequent Stem Cell Gene Silencing and Age-Dependent Extinction of Expression of Human β -Globin in Engrafted Mice

Tissue distribution and immunoreactivity of heme-regulated eIF-2α kinase determined by monoclonal antibodies

Regulation of heme-regulated eIF-2α kinase and its expression in erythroid cells

Effect of Phosphorylation of the α -Subunit of Eukaryotic Initiation Factor 2 on the Function of Reversing Factor in the Initiation of Protein Synthesis

Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases

Hemin Inhibits Internalization of Transferrin by Reticulocytes and Promotes Phosphorylation of the Membrane Transferrin Receptor

Relationship between Phosphorylation and Activity of Heme-Regulated Eukaryotic Initiation Factor 2α Kinase

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