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SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial

Clinical infectious diseases, 2021-06, Vol.72 (12), p.2132-2140

2021

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Genomic insights to SAR86, an abundant and uncultivated marine bacterial lineage

The ISME Journal, 2012-06, Vol.6 (6), p.1186-1199

2012

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Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

Science (American Association for the Advancement of Science), 2012-12, Vol.338 (6112), p.1344-1348

2012

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Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (26), p.E2390-E2399

2013

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Efficient de novo assembly of single-cell bacterial genomes from short-read data sets

Nature biotechnology, 2011-10, Vol.29 (10), p.915-921

2011

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Going deeper: metagenome of a hadopelagic microbial community

PloS one, 2011-05, Vol.6 (5), p.e20388-e20388

2011

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Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform

Genome research, 2013-05, Vol.23 (5), p.867-877

2013

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SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection

The New England journal of medicine, 2022-01, Vol.386 (3), p.220-229

2022

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A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection

The Journal of infectious diseases, 2016-07, Vol.214 (2), p.173-181

2016

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Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli

PloS one, 2015-05, Vol.10 (5), p.e0123315

2015

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in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteers

Proceedings of the National Academy of Sciences - PNAS, 2007-11, Vol.104 (46), p.18229-18234

2007

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Manufacturing Processes of a Purified Microbiome Therapeutic Reduce Risk of Transmission of Potential Bacterial Pathogens in Donor Stool

The Journal of infectious diseases, 2023-11, Vol.228 (10), p.1452-1455

2023

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Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection

Clinical infectious diseases, 2024-04, Vol.78 (4), p.833-841

2024

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Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation

The EMBO journal, 1997-06, Vol.16 (11), p.3303-3311

1997

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Stationary-Phase Mutation in the Bacterial Chromosome: Recombination Protein and DNA Polymerase IV Dependence

Proceedings of the National Academy of Sciences - PNAS, 2001-07, Vol.98 (15), p.8334-8341

2001

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The PapC Usher Forms an Oligomeric Channel: Implications for Pilus Biogenesis across the Outer Membrane

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (6), p.3146-3151

1998

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Manufacturing Process of SER-109, a Purified Investigational Microbiome Therapeutic, Reduces Risk of Coronavirus Transmission From Donor Stool

Open forum infectious diseases, 2022-09, Vol.9 (9), p.ofac448-ofac448

2022

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The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli

Molecular microbiology, 2010-07, Vol.77 (2), p.415

2010

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Reply to Lagier et al

The Journal of infectious diseases, 2017-01, Vol.215 (1), p.162-164

2017

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General Stress Response Regulator RpoS in Adaptive Mutation and Amplification in Escherichia coli

Genetics (Austin), 2004-02, Vol.166 (2), p.669-680

2004

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σE stress response is required for stress-induced mutation and amplification in Escherichia coli

Molecular microbiology, 2010-07, Vol.77 (2), p.415-430

2010

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SOS Mutator DNA Polymerase IV Functions in Adaptive Mutation and Not Adaptive Amplification

Molecular cell, 2001-03, Vol.7 (3), p.571-579

2001

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A phase 1b study to evaluate safety, tolerability, pharmacokinetics, and efficacy of SER-155 in adults undergoing hematopoietic stem cell transplantation to reduce the risk of infection and graft versus host disease (NCT04995653)

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.TPS7074-TPS7074

2022

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A Phase 1b Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of an Investigational Microbiome Therapeutic, SER-155, in Adults Undergoing Hematopoietic Stem Cell Transplantation

Blood, 2022-11, Vol.140 (Supplement 1), p.10532-10533

2022

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Assessment of a rationally-designed experimental microbial consortium to reduce systemic inflammation in a murine model of chemotherapy-induced mucositis

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.e15062-e15062

2022

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SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial

Genomic insights to SAR86, an abundant and uncultivated marine bacterial lineage

Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

Candidate phylum TM6 genome recovered from a hospital sink biofilm provides genomic insights into this uncultivated phylum

Efficient de novo assembly of single-cell bacterial genomes from short-read data sets

Going deeper: metagenome of a hadopelagic microbial community

Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform

SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection

A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection

Atypical Role for PhoU in Mutagenic Break Repair under Stress in Escherichia coli

in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteers

Manufacturing Processes of a Purified Microbiome Therapeutic Reduce Risk of Transmission of Potential Bacterial Pathogens in Donor Stool

Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection

Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation

Stationary-Phase Mutation in the Bacterial Chromosome: Recombination Protein and DNA Polymerase IV Dependence

The PapC Usher Forms an Oligomeric Channel: Implications for Pilus Biogenesis across the Outer Membrane

Manufacturing Process of SER-109, a Purified Investigational Microbiome Therapeutic, Reduces Risk of Coronavirus Transmission From Donor Stool

The sigma(E) stress response is required for stress-induced mutation and amplification in Escherichia coli

Reply to Lagier et al

General Stress Response Regulator RpoS in Adaptive Mutation and Amplification in Escherichia coli

σE stress response is required for stress-induced mutation and amplification in Escherichia coli

SOS Mutator DNA Polymerase IV Functions in Adaptive Mutation and Not Adaptive Amplification

A phase 1b study to evaluate safety, tolerability, pharmacokinetics, and efficacy of SER-155 in adults undergoing hematopoietic stem cell transplantation to reduce the risk of infection and graft versus host disease (NCT04995653)

A Phase 1b Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of an Investigational Microbiome Therapeutic, SER-155, in Adults Undergoing Hematopoietic Stem Cell Transplantation

Assessment of a rationally-designed experimental microbial consortium to reduce systemic inflammation in a murine model of chemotherapy-induced mucositis

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