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Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

European journal of medicinal chemistry, 2019-12, Vol.183, p.111681-111681, Article 111681

2019

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A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 2: Non-DSM compounds

Bioorganic chemistry, 2024-12, Vol.153, p.107754, Article 107754

2024

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Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication

Antiviral research, 2021-05, Vol.189, p.105057-105057, Article 105057

2021

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Computational Method for Structure-Based Analysis of SAR Transfer

Journal of medicinal chemistry, 2020-02, Vol.63 (3), p.1388-1396

2020

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Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor

FEBS letters, 2023-08, Vol.597 (16), p.2119-2132

2023

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Tandem mass spectrometry of homologous 3‐hydroxyfurazan and nitrile amino acids: Analysis of cooperative interactions and fragmentation processes

Journal of mass spectrometry., 2024-06, Vol.59 (6), p.e5043-n/a

2024

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Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication

Antiviral research, 2023-11, Vol.219, p.105734-105734, Article 105734

2023

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Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

Recent patents on anti-cancer drug discovery, 2018-01, Vol.13 (1), p.86

2018

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Targeting Myeloid Differentiation Using Potent 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

Journal of medicinal chemistry, 2018-07, Vol.61 (14), p.6034-6055

2018

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Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study

Molecules (Basel, Switzerland), 2022-06, Vol.27 (12), p.3660

2022

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A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds

Bioorganic chemistry, 2024-05, Vol.146, p.107249-107249, Article 107249

2024

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An alternative conformation of the N‐terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent

Acta crystallographica. Section D, Biological crystallography., 2024-06, Vol.80 (6), p.386-396

2024

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Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans

European journal of mass spectrometry (Chichester, England), 2024-02, Vol.30 (1), p.38-46

2024

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Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold: SAR of the Biphenyl Moiety

Journal of medicinal chemistry, 2021-05, Vol.64 (9), p.5404-5428

2021

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Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.12701-12724

2022

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Applications of Heterocycles in the Design of Drugs and Agricultural Products

1, 2021

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Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach

European journal of medicinal chemistry, 2017-10, Vol.139, p.936-946

2017

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Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents

Mini reviews in medicinal chemistry, 2024-06, Vol.24 (22), p.1983-2007

2024

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Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds

European journal of medicinal chemistry, 2017-03, Vol.129, p.287-302

2017

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Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3

ACS medicinal chemistry letters, 2019-04, Vol.10 (4), p.437-443

2019

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4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site

European journal of medicinal chemistry, 2018-10, Vol.158, p.311-321

2018

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Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies

European journal of medicinal chemistry, 2019-02, Vol.163 (1), p.266-280

2019

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Fragmentation pathways arising from protonation at different sites in aminoalkyl‐substituted 3‐hydroxy‐1,2,5‐oxadiazoles (3‐hydroxyfurazans)

Rapid communications in mass spectrometry, 2018-08, Vol.32 (16), p.1403-1413

2018

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Use of the 4‑Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4467-4482

2019

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Five-Membered N‑Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ‑Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

Journal of medicinal chemistry, 2019-06, Vol.62 (12), p.5797-5809

2019

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Dihydroorotate dehydrogenase inhibitors in anti-infective drug research

A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 2: Non-DSM compounds

Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication

Computational Method for Structure-Based Analysis of SAR Transfer

Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor

Tandem mass spectrometry of homologous 3‐hydroxyfurazan and nitrile amino acids: Analysis of cooperative interactions and fragmentation processes

Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication

Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

Targeting Myeloid Differentiation Using Potent 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study

A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds

An alternative conformation of the N‐terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent

Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold: SAR of the Biphenyl Moiety

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2‑Hydroxypyrazolo[1,5‑a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

Applications of Heterocycles in the Design of Drugs and Agricultural Products

Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach

Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents

Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds

Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site

Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies

Fragmentation pathways arising from protonation at different sites in aminoalkyl‐substituted 3‐hydroxy‐1,2,5‐oxadiazoles (3‐hydroxyfurazans)

Use of the 4‑Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

Five-Membered N‑Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ‑Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

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