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The STIM1-binding site nexus remotely controls Orai1 channel gating

Nature communications, 2016-12, Vol.7 (1), p.13725-13725, Article 13725

2016

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STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

Nature communications, 2015-09, Vol.6 (1), p.8395-8395, Article 8395

2015

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The Orai1 Store-operated Calcium Channel Functions as a Hexamer

The Journal of biological chemistry, 2016-12, Vol.291 (50), p.25764-25775

2016

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The STIM-Orai coupling interface and gating of the Orai1 channel

Cell calcium (Edinburgh), 2017-05, Vol.63, p.8-13

2017

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Cross-linking of Orai1 channels by STIM proteins

Proceedings of the National Academy of Sciences - PNAS, 2018-04, Vol.115 (15), p.E3398-E3407

2018

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Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor

The Journal of biological chemistry, 2018-08, Vol.293 (33), p.12962-12974

2018

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The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry

Store-Operated Ca²⁺ Entry (SOCE) Pathways, p.83-98

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Substitution of Aminomethyl at the Meta-Position Enhances the Inactivation of O6-Alkylguanine-DNA Alkyltransferase by O6-Benzylguanine

Journal of medicinal chemistry, 2008-11, Vol.51 (22), p.7144-7153

2008

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In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene

The Journal of clinical investigation, 2009-07, Vol.119 (7), p.1952-1963

2009

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Alkyltransferase-Mediated Toxicity of 1,3-Butadiene Diepoxide

Chemical research in toxicology, 2008-09, Vol.21 (9), p.1851-1861

2008

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Substitution of Aminomethyl at the Meta-Position Enhances the Inactivation of O 6-Alkylguanine-DNA Alkyltransferase by O 6-Benzylguanine

Journal of medicinal chemistry, 2008-11, Vol.51 (22), p.7144-7153

2008

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Inactivation of O 6-Alkylguanine-DNA Alkyltransferase by Folate Esters of O 6-Benzyl-2‘-deoxyguanosine and of O 6-[4-(Hydroxymethyl)benzyl]guanine

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5193-5201

2007

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2-Amino-O 4-benzylpteridine Derivatives: Potent Inactivators of O 6-Alkylguanine-DNA Alkyltransferase

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3887-3891

2004

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Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase

The Journal of biological chemistry, 2004-02, Vol.279 (6), p.4250-4259

2004

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Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5193

2007

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Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications

Cancer research (Chicago, Ill.), 2008-12, Vol.68 (23), p.9973-9981

2008

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Activation of bis-Electrophiles to Mutagenic Conjugates by Human O 6-Alkylguanine-DNA Alkyltransferase

Chemical research in toxicology, 2004-07, Vol.17 (7), p.972-982

2004

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β-Glucuronidase-Cleavable Prodrugs of O 6-Benzylguanine and O 6-Benzyl-2‘-deoxyguanosine

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.256-261

2005

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O 6-Pyridyloxobutylguanine Adducts Contribute to the Mutagenic Properties of Pyridyloxobutylating Agents

Chemical research in toxicology, 2005-10, Vol.18 (10), p.1619-1625

2005

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Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins

Environmental and molecular mutagenesis, 2009-07, Vol.50 (6), p.502-514

2009

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Human variants of O6-alkylguanine-DNA alkyltransferase

DNA repair, 2007-08, Vol.6 (8), p.1071-1078

2007

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Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model

Cancer chemotherapy and pharmacology, 2011-06, Vol.67 (6), p.1291-1297

2011

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Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase

Biochemical pharmacology, 2008-02, Vol.75 (3), p.618-626

2008

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Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine

Biochemical pharmacology, 2002-04, Vol.63 (8), p.1431-1442

2002

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Ion Conductance of Orai1 Channel Selectivity-Filter Heterodimers

Biophysical journal, 2018-02, Vol.114 (3), p.132a-132a

2018

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The STIM1-binding site nexus remotely controls Orai1 channel gating

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

The Orai1 Store-operated Calcium Channel Functions as a Hexamer

The STIM-Orai coupling interface and gating of the Orai1 channel

Cross-linking of Orai1 channels by STIM proteins

Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor

The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry

Substitution of Aminomethyl at the Meta-Position Enhances the Inactivation of O6-Alkylguanine-DNA Alkyltransferase by O6-Benzylguanine

In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene

Alkyltransferase-Mediated Toxicity of 1,3-Butadiene Diepoxide

Substitution of Aminomethyl at the Meta-Position Enhances the Inactivation of O 6-Alkylguanine-DNA Alkyltransferase by O 6-Benzylguanine

Inactivation of O 6-Alkylguanine-DNA Alkyltransferase by Folate Esters of O 6-Benzyl-2‘-deoxyguanosine and of O 6-[4-(Hydroxymethyl)benzyl]guanine

2-Amino-O 4-benzylpteridine Derivatives: Potent Inactivators of O 6-Alkylguanine-DNA Alkyltransferase

Characterization of a Mutagenic DNA Adduct Formed from 1,2-Dibromoethane by O6-Alkylguanine-DNA Alkyltransferase

Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine

Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications

Activation of bis-Electrophiles to Mutagenic Conjugates by Human O 6-Alkylguanine-DNA Alkyltransferase

β-Glucuronidase-Cleavable Prodrugs of O 6-Benzylguanine and O 6-Benzyl-2‘-deoxyguanosine

O 6-Pyridyloxobutylguanine Adducts Contribute to the Mutagenic Properties of Pyridyloxobutylating Agents

Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins

Human variants of O6-alkylguanine-DNA alkyltransferase

Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model

Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase

Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine

Ion Conductance of Orai1 Channel Selectivity-Filter Heterodimers

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