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The impact of population demography and selection on the genetic architecture of complex traits

PLoS genetics, 2014-05, Vol.10 (5), p.e1004379-e1004379

2014

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The distribution of deleterious genetic variation in human populations

Current opinion in genetics & development, 2014-12, Vol.29, p.139-146

Lohmueller, Kirk E

2014

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A model-based approach for identifying signatures of ancient balancing selection in genetic data

PLoS genetics, 2014-08, Vol.10 (8), p.e1004561-e1004561

2014

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Negative selection on complex traits limits phenotype prediction accuracy between populations

American journal of human genetics, 2021-04, Vol.108 (4), p.620-631

2021

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Purging of Strongly Deleterious Mutations Explains Long-Term Persistence and Absence of Inbreeding Depression in Island Foxes

Current biology, 2018-11, Vol.28 (21), p.3487-3494.e4

2018

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Genomic Flatlining in the Endangered Island Fox

Current biology, 2016-05, Vol.26 (9), p.1183-1189

2016

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Deleterious variation shapes the genomic landscape of introgression

PLoS genetics, 2018-10, Vol.14 (10), p.e1007741-e1007741

2018

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Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

PLoS genetics, 2020-05, Vol.16 (5), p.e1008827-e1008827

2020

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Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression

Evolution letters, 2021-02, Vol.5 (1), p.33-47

2021

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Gene expression drives the evolution of dominance

Nature communications, 2018-07, Vol.9 (1), p.2750-11, Article 2750

2018

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Selection and Reduced Population Size Cannot Explain Higher Amounts of Neandertal Ancestry in East Asian than in European Human Populations

American journal of human genetics, 2015-03, Vol.96 (3), p.454-461

2015

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Natural selection reduced diversity on human y chromosomes

PLoS genetics, 2014-01, Vol.10 (1), p.e1004064-e1004064

2014

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Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

PLoS genetics, 2021-07, Vol.17 (7), p.e1009676-e1009676

2021

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Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs

Proceedings of the National Academy of Sciences - PNAS, 2016-01, Vol.113 (1), p.152-157

2016

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Assessing the evolutionary impact of amino acid mutations in the human genome

PLoS genetics, 2008-05, Vol.4 (5), p.e1000083-e1000083

2008

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High-quality genome and methylomes illustrate features underlying evolutionary success of oaks

Nature communications, 2022-04, Vol.13 (1), p.2047-2047, Article 2047

2022

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Human Population Genomics: Introduction to Essential Concepts and Applications

1st ed. 2021., 2021

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A signature of Neanderthal introgression on molecular mechanisms of environmental responses

PLoS genetics, 2021-09, Vol.17 (9), p.e1009493

2021

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Determining the Effect of Natural Selection on Linked Neutral Divergence across Species

PLoS genetics, 2016-08, Vol.12 (8), p.e1006199-e1006199

2016

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Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome

PLoS genetics, 2011-10, Vol.7 (10), p.e1002326-e1002326

2011

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Estimation of allele frequency and association mapping using next-generation sequencing data

BMC bioinformatics, 2011-06, Vol.12 (1), p.231-231, Article 231

2011

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Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

Nature genetics, 2003-02, Vol.33 (2), p.177-182

2003

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Comparison of Single Genome and Allele Frequency Data Reveals Discordant Demographic Histories

G3 : genes - genomes - genetics, 2017-11, Vol.7 (11), p.3605-3620

2017

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The genomic footprint of whaling and isolation in fin whale populations

Nature communications, 2023-09, Vol.14 (1), p.5465-5465, Article 5465

2023

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Identification and characterization of constrained non-exonic bases lacking predictive epigenomic and transcription factor binding annotations

Nature communications, 2020-12, Vol.11 (1), p.6168-6168, Article 6168

2020

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The impact of population demography and selection on the genetic architecture of complex traits

The distribution of deleterious genetic variation in human populations

A model-based approach for identifying signatures of ancient balancing selection in genetic data

Negative selection on complex traits limits phenotype prediction accuracy between populations

Purging of Strongly Deleterious Mutations Explains Long-Term Persistence and Absence of Inbreeding Depression in Island Foxes

Genomic Flatlining in the Endangered Island Fox

Deleterious variation shapes the genomic landscape of introgression

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression

Gene expression drives the evolution of dominance

Selection and Reduced Population Size Cannot Explain Higher Amounts of Neandertal Ancestry in East Asian than in European Human Populations

Natural selection reduced diversity on human y chromosomes

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs

Assessing the evolutionary impact of amino acid mutations in the human genome

High-quality genome and methylomes illustrate features underlying evolutionary success of oaks

Human Population Genomics: Introduction to Essential Concepts and Applications

A signature of Neanderthal introgression on molecular mechanisms of environmental responses

Determining the Effect of Natural Selection on Linked Neutral Divergence across Species

Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome

Estimation of allele frequency and association mapping using next-generation sequencing data

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

Comparison of Single Genome and Allele Frequency Data Reveals Discordant Demographic Histories

The genomic footprint of whaling and isolation in fin whale populations

Identification and characterization of constrained non-exonic bases lacking predictive epigenomic and transcription factor binding annotations

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