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Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Bioorganic & medicinal chemistry letters, 2014-10, Vol.24 (19), p.4708-4713

2014

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Design of 4‑Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

Journal of medicinal chemistry, 2015-11, Vol.58 (22), p.9027-9040

2015

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CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis

Drug metabolism and disposition, 2009-08, Vol.37 (8), p.1682-1689

2009

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Polymorphic Variants of CYP2C9: Mechanisms Involved in Reduced Catalytic Activity

Molecular pharmacology, 2007-11, Vol.72 (5), p.1280-1288

2007

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Pharmacokinetic interaction of the antiparasitic agents ivermectin and spinosad in dogs

Drug metabolism and disposition, 2011-05, Vol.39 (5), p.789-795

2011

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Evaluation of Escherichia coli membrane preparations of canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with coexpressed canine cytochrome P450 reductase

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.457-461

2009

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In vitro drug-drug interaction screens for canine veterinary medicines: evaluation of cytochrome P450 reversible inhibition

Drug metabolism and disposition, 2008-08, Vol.36 (8), p.1512-1518

2008

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Pharmacokinetics and pharmacodynamics of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs

American journal of veterinary research, 2020-08, Vol.81 (8), p.656-664

2020

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The effect of fluconazole on oral methadone in dogs

Veterinary anaesthesia and analgesia, 2019-07, Vol.46 (4), p.501-509

2019

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Heteroactivator effects on the coupling and spin state equilibrium of CYP2C9

Archives of biochemistry and biophysics, 2006-05, Vol.449 (1), p.115-129

2006

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Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors

Journal of medicinal chemistry, 2004-12, Vol.47 (27), p.6768-6776

2004

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VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

The Journal of infectious diseases, 2015-11, Vol.212 (9), p.1439-1448

2015

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Current cytochrome P450 phenotyping methods applied to metabolic drug-drug interaction prediction in dogs

Drug metabolism and disposition, 2010-03, Vol.38 (3), p.396-404

2010

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Differential Roles of Arg97, Asp293, and Arg108 in Enzyme Stability and Substrate Specificity of CYP2C9

Molecular pharmacology, 2004-04, Vol.65 (4), p.842-850

2004

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Multiple-dose pharmacokinetics and opioid effects of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs

American journal of veterinary research, 2021-03, Vol.82 (3), p.171-180

2021

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Three-dimensional quantitative structure-activity relationship analysis of cytochromes p450: effect of incorporating higher-affinity ligands and potential new applications

Drug metabolism and disposition, 2005-07, Vol.33 (7), p.873-878

2005

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CYP2C9 Genotype-Dependent Effects on in Vitro Drug-Drug Interactions: Switching of Benzbromarone Effect from Inhibition to Activation in the CYP2C9.3 Variant

Molecular pharmacology, 2005-09, Vol.68 (3), p.644-651

2005

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Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes

Xenobiotica, 2019-02, Vol.49 (2), p.177-186

2019

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Quantitative Binding Models for CYP2C9 Based on Benzbromarone Analogues

Biochemistry (Easton), 2004-06, Vol.43 (22), p.6948-6958

2004

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Identification of binding sites of non-I-helix water molecules in mammalian cytochromes p450

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.1954-1957

2006

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A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.967-971

2003

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Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N‑(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type and Mutant mGlu1 Receptors Found in Schizophrenics

Journal of medicinal chemistry, 2015-10, Vol.58 (20), p.7959-7971

2015

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Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.614-622

2007

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Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (13), p.2720-2725

2015

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Subcutaneous meloxicam suspension pharmacokinetics in mice and dose considerations for postoperative analgesia

Journal of veterinary pharmacology and therapeutics, 2016-08, Vol.39 (4), p.356-362

2016

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Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Design of 4‑Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2

CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis

Polymorphic Variants of CYP2C9: Mechanisms Involved in Reduced Catalytic Activity

Pharmacokinetic interaction of the antiparasitic agents ivermectin and spinosad in dogs

Evaluation of Escherichia coli membrane preparations of canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with coexpressed canine cytochrome P450 reductase

In vitro drug-drug interaction screens for canine veterinary medicines: evaluation of cytochrome P450 reversible inhibition

Pharmacokinetics and pharmacodynamics of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs

The effect of fluconazole on oral methadone in dogs

Heteroactivator effects on the coupling and spin state equilibrium of CYP2C9

Charge and Substituent Effects on Affinity and Metabolism of Benzbromarone-Based CYP2C19 Inhibitors

VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Current cytochrome P450 phenotyping methods applied to metabolic drug-drug interaction prediction in dogs

Differential Roles of Arg97, Asp293, and Arg108 in Enzyme Stability and Substrate Specificity of CYP2C9

Multiple-dose pharmacokinetics and opioid effects of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs

Three-dimensional quantitative structure-activity relationship analysis of cytochromes p450: effect of incorporating higher-affinity ligands and potential new applications

CYP2C9 Genotype-Dependent Effects on in Vitro Drug-Drug Interactions: Switching of Benzbromarone Effect from Inhibition to Activation in the CYP2C9.3 Variant

Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes

Quantitative Binding Models for CYP2C9 Based on Benzbromarone Analogues

Identification of binding sites of non-I-helix water molecules in mammalian cytochromes p450

A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives

Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common

Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility

Subcutaneous meloxicam suspension pharmacokinetics in mice and dose considerations for postoperative analgesia

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