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Intranasal delivery of biologics to the central nervous system

Advanced drug delivery reviews, 2012-05, Vol.64 (7), p.614-628

2012

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Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

Frontiers in physiology, 2020-08, Vol.11, p.914

2020

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Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration

Journal of cerebral blood flow and metabolism, 2015-03, Vol.35 (3), p.371-381

2015

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Distribution of insulin in trigeminal nerve and brain after intranasal administration

Scientific reports, 2019-02, Vol.9 (1), p.2621-2621, Article 2621

2019

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Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery

Journal of controlled release, 2018-09, Vol.286, p.467-484

2018

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Perivascular and Perineural Pathways Involved in Brain Delivery and Distribution of Drugs after Intranasal Administration

Pharmaceutics, 2019-11, Vol.11 (11), p.598

2019

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Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

The AAPS journal, 2017-07, Vol.19 (4), p.910-920

2017

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Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation

Journal of cerebral blood flow and metabolism, 2010-09, Vol.30 (9), p.1625-1636

2010

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βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling

Nature communications, 2022-03, Vol.13 (1), p.1326-1326, Article 1326

2022

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Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery

Scientific reports, 2016-08, Vol.6 (1), p.31732-31732, Article 31732

2016

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Occludin oligomeric assemblies at tight junctions of the blood–brain barrier are altered by hypoxia and reoxygenation stress

Journal of neurochemistry, 2009-07, Vol.110 (1), p.58-71

2009

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High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats

Pharmaceutics, 2022-04, Vol.14 (5), p.949

2022

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High Resolution Multiplex Confocal Imaging of the Neurovascular Unit in Health and Experimental Ischemic Stroke

Cells (Basel, Switzerland), 2023-02, Vol.12 (4), p.645

2023

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The role of oxidative stress in blood–brain barrier disruption during ischemic stroke: Antioxidants in clinical trials

Biochemical pharmacology, 2024-10, Vol.228, p.116186, Article 116186

2024

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Oatp (Organic Anion Transporting Polypeptide)-Mediated Transport: A Mechanism for Atorvastatin Neuroprotection in Stroke

Stroke (1970), 2023-11, Vol.54 (11), p.2875-2885

2023

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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor- β /Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)

Drug metabolism and disposition, 2022-07, Vol.50 (7), p.942-956

2022

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Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

American journal of physiology. Heart and circulatory physiology, 2012-02, Vol.302 (3), p.H582-H593

2012

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Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation

Journal of cerebral blood flow and metabolism, 2011-02, Vol.31 (2), p.790-791

2011

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Abstract TP121: Organic Anion Transporting Polypeptide (Oatp)-Mediated Transport is Required for Statin-Induced Neuroprotection: A Role for Blood-Brain Barrier Transporters in Stroke Treatment

Stroke (1970), 2020-02, Vol.51 (Suppl_1)

2020

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Abstract TP205: Organic Anion Transporting Polypeptides: Endogenous Blood-brain Barrier Transporters That Are Required For Statins To Exert Neuroprotective Effects In Ischemic Stroke

Stroke (1970), 2023-02, Vol.54 (Suppl_1)

2023

Volltextzugriff (PDF)

Intranasal delivery of biologics to the central nervous system: DELIVERY OF THERAPEUTICS TO THE CENTRAL NERVOUS SYSTEM

Advanced drug delivery reviews, 2012, Vol.64 (7), p.614-628

2012

Volltextzugriff (PDF)

Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches

2nd ed. 2022

Volltextzugriff (PDF)

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

American journal of physiology. Heart and circulatory physiology, 2012, Vol.71 (2)

2012

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Intranasal Drug Delivery to the Brain

Drug Delivery to the Brain, p.461-500

Volltextzugriff (PDF)

Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology

Oncogene, 2014-06, Vol.33 (23), p.2949-2955

2014

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Intranasal delivery of biologics to the central nervous system

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration

Distribution of insulin in trigeminal nerve and brain after intranasal administration

Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery

Perivascular and Perineural Pathways Involved in Brain Delivery and Distribution of Drugs after Intranasal Administration

Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System

Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation

βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling

Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery

Occludin oligomeric assemblies at tight junctions of the blood–brain barrier are altered by hypoxia and reoxygenation stress

High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats

High Resolution Multiplex Confocal Imaging of the Neurovascular Unit in Health and Experimental Ischemic Stroke

The role of oxidative stress in blood–brain barrier disruption during ischemic stroke: Antioxidants in clinical trials

Oatp (Organic Anion Transporting Polypeptide)-Mediated Transport: A Mechanism for Atorvastatin Neuroprotection in Stroke

Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor- β /Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors (i.e., Statins)

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

Oxidative stress increases blood-brain barrier permeability and induces alterations in occludin during hypoxia-reoxygenation

Abstract TP121: Organic Anion Transporting Polypeptide (Oatp)-Mediated Transport is Required for Statin-Induced Neuroprotection: A Role for Blood-Brain Barrier Transporters in Stroke Treatment

Abstract TP205: Organic Anion Transporting Polypeptides: Endogenous Blood-brain Barrier Transporters That Are Required For Statins To Exert Neuroprotective Effects In Ischemic Stroke

Intranasal delivery of biologics to the central nervous system: DELIVERY OF THERAPEUTICS TO THE CENTRAL NERVOUS SYSTEM

Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches

Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain

Intranasal Drug Delivery to the Brain

Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology

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