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Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases

mAbs, 2016-01, Vol.8 (1), p.141-149

2016

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High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G

Molecular Immunology, 2006-03, Vol.43 (8), p.1183-1193

2006

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Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3

Cancer Immunology, Immunotherapy, 2006-07, Vol.55 (7), p.785-796

2006

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Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class

Journal of immunotherapy, 2007-11, Vol.30 (8), p.798-807

2007

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MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

Molecular Immunology, 2006-03, Vol.43 (8), p.1129-1143

2006

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New challenges and opportunities in nonclinical safety testing of biologics

Regulatory toxicology and pharmacology, 2014-07, Vol.69 (2), p.226-233

2014

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N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II

Metabolism, clinical and experimental, 2006-06, Vol.55 (6), p.711-721

2006

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Nonclinical safety testing of biopharmaceuticals – Addressing current challenges of these novel and emerging therapies

Regulatory toxicology and pharmacology, 2015-10, Vol.73 (1), p.265-275

2015

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Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells

Leukemia research, 2009-03, Vol.33 (3), p.465-473

2009

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A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients

European journal of cancer (1990), 2006-10, Vol.42 (15), p.2530-2538

2006

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Characterization of Physicochemical Parameters in Toxicology

Regulatory Toxicology, p.99-106

Locher, Mathias

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Monoclonal Antibodies: Discovery and Protein Engineering

Regulatory Toxicology, p.83-98

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A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF

Molecular immunology, 2007-02, Vol.44 (5), p.916-925

2007

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Activation of T Cells by Bispecific Single-Chain Construct MT103 (MEDI-538) Is Strictly Target Cell-Dependent

Blood, 2006-11, Vol.108 (11), p.3889-3889

2006

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Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects

European journal of clinical pharmacology, 2003-04, Vol.58 (12), p.795-802

2003

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Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Cancer Immunology, Immunotherapy, 2007-04, Vol.56 (4), p.459-468

2007

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Effect of R(+)α-Lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes

Metabolism, clinical and experimental, 2004-02, Vol.53 (2), p.165-173

2004

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Exchanging human Fc[gamma]1 with murine Fc[gamma]2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Cancer immunology, immunotherapy, 2007-04, Vol.56 (4), p.459

2007

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Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Cancer immunology, immunotherapy : CII, 2007-04, Vol.56 (4), p.459-468

2007

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Pharmacokinetic/Pharmacodynamic Modeling of Luteinizing Hormone (LH) Suppression and LH Surge Delay by Cetrorelix after Single and Multiple Doses in Healthy Premenopausal Women

Journal of clinical pharmacology, 2003-03, Vol.43 (3), p.243-251

2003

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Intranasal Loteprednol Etabonate in Healthy Male Subjects: Pharmacokinetics and Effects on Endogenous Cortisol

Journal of clinical pharmacology, 2004-05, Vol.44 (5), p.510-519

2004

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Pharmacokinetic-Pharmacodynamic Modeling of Testosterone and Luteinizing Hormone Suppression by Cetrorelix in Healthy Volunteers

Journal of clinical pharmacology, 2000-03, Vol.40 (3), p.266-274

2000

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Disposition and metabolism of cetrorelix, a potent luteinizing hormone-releasing hormone antagonist, in rats and dogs

Drug metabolism and disposition, 2000-01, Vol.28 (1), p.10

2000

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Interaction of α-Lipoic acid enantiomers and homologues with the enzyme components of the mammalian pyruvate dehydrogenase complex

Biochemical pharmacology, 1995-08, Vol.50 (5), p.637-646

1995

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1-Naphthol conjugation in isolated cells from liver, jejunum, ileum, colon and kidney of the guinea pig

Biochemical pharmacology, 1985-03, Vol.34 (5), p.697-701

1985

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Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases

High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G

Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3

Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class

MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors

New challenges and opportunities in nonclinical safety testing of biologics

N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II

Nonclinical safety testing of biopharmaceuticals – Addressing current challenges of these novel and emerging therapies

Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells

A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients

Characterization of Physicochemical Parameters in Toxicology

Monoclonal Antibodies: Discovery and Protein Engineering

A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF

Activation of T Cells by Bispecific Single-Chain Construct MT103 (MEDI-538) Is Strictly Target Cell-Dependent

Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects

Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Effect of R(+)α-Lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes

Exchanging human Fc[gamma]1 with murine Fc[gamma]2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model

Pharmacokinetic/Pharmacodynamic Modeling of Luteinizing Hormone (LH) Suppression and LH Surge Delay by Cetrorelix after Single and Multiple Doses in Healthy Premenopausal Women

Intranasal Loteprednol Etabonate in Healthy Male Subjects: Pharmacokinetics and Effects on Endogenous Cortisol

Pharmacokinetic-Pharmacodynamic Modeling of Testosterone and Luteinizing Hormone Suppression by Cetrorelix in Healthy Volunteers

Disposition and metabolism of cetrorelix, a potent luteinizing hormone-releasing hormone antagonist, in rats and dogs

Interaction of α-Lipoic acid enantiomers and homologues with the enzyme components of the mammalian pyruvate dehydrogenase complex

1-Naphthol conjugation in isolated cells from liver, jejunum, ileum, colon and kidney of the guinea pig

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