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Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2269-2300

2016

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Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

The Journal of biological chemistry, 2011-05, Vol.286 (18), p.16052-16062

2011

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Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin's Anorectic Signaling Actions

Scientific reports, 2017-02, Vol.7 (1), p.41795-41795, Article 41795

2017

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Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.10013-10030

2014

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Rho kinase (ROCK) inhibitors and their application to inflammatory disorders

Current topics in medicinal chemistry, 2009-05, Vol.9 (8), p.704-723

2009

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Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo

The Journal of biological chemistry, 2013-01, Vol.288 (2), p.1079-1087

2013

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Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway

Molecular and cellular biology, 2015-06, Vol.35 (11), p.1992-2006

2015

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Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats

The Journal of biological chemistry, 2013-02, Vol.288 (6), p.4000-4011

2013

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Rho kinase inhibitors: a patent review (2012 - 2013)

Expert opinion on therapeutic patents, 2014-03, Vol.24 (3), p.295-307

2014

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Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow-Derived Mouse Mesenchymal Stem Cells via a p53-Dependent Mechanism: Implications for Long-Term Culture Expansion

Stem cells (Dayton, Ohio), 2012-05, Vol.30 (5), p.975-987

2012

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Enzyme Kinetics and Interaction Studies for Human JNK1β1 and Substrates Activating Transcription Factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun)

The Journal of biological chemistry, 2012-04, Vol.287 (16), p.13291-13302

2012

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Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases

Structure (London), 2012-12, Vol.20 (12), p.2174-2184

2012

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Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9276-9276

2016

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Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1846-1861

2015

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Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors

Journal of medicinal chemistry, 2013-05, Vol.56 (9), p.3568-3581

2013

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Synthesis of Benzoquinone Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid

Angewandte Chemie (International ed.), 2013-04, Vol.52 (18), p.4800-4804

International ed. in English, 2013

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Selective Inhibition of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry of the Sab Kinase Interacting Motif-1 (KIM1)

ACS chemical biology, 2011-08, Vol.6 (8), p.808-818

2011

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Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (1), p.161-164

2014

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Pyridopyrimidinone Derivatives as Potent and Selective c‑Jun N‑Terminal Kinase (JNK) Inhibitors

ACS medicinal chemistry letters, 2015-04, Vol.6 (4), p.413-418

2015

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Synthesis of Potent Bicyclic Bisarylimidazole c-Jun N-Terminal Kinase Inhibitors by Catalytic C−H Bond Activation

Journal of the American Chemical Society, 2007-01, Vol.129 (3), p.490-491

2007

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Inhibitors of c-jun-N-terminal kinase (JNK)

Mini reviews in medicinal chemistry, 2008-07, Vol.8 (8), p.755-766

2008

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Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) Inhibitors

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6642-6645

2008

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Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.419-431

2010

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A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

ACS chemical biology, 2013-08, Vol.8 (8), p.1747-1754

2013

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Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

The Journal of biological chemistry, 2009-05, Vol.284 (19), p.12853-12861

2009

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Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation

Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin's Anorectic Signaling Actions

Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Rho kinase (ROCK) inhibitors and their application to inflammatory disorders

Blocking c-Jun N-terminal Kinase (JNK) Translocation to the Mitochondria Prevents 6-Hydroxydopamine-induced Toxicity in Vitro and in Vivo

Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway

Inhibition of JNK Mitochondrial Localization and Signaling Is Protective against Ischemia/Reperfusion Injury in Rats

Rho kinase inhibitors: a patent review (2012 - 2013)

Atmospheric Oxygen Inhibits Growth and Differentiation of Marrow-Derived Mouse Mesenchymal Stem Cells via a p53-Dependent Mechanism: Implications for Long-Term Culture Expansion

Enzyme Kinetics and Interaction Studies for Human JNK1β1 and Substrates Activating Transcription Factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun)

Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases

Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives

Bis-aryl Urea Derivatives as Potent and Selective LIM Kinase (Limk) Inhibitors

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors

Synthesis of Benzoquinone Ansamycin-Inspired Macrocyclic Lactams from Shikimic Acid

Selective Inhibition of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry of the Sab Kinase Interacting Motif-1 (KIM1)

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors

Pyridopyrimidinone Derivatives as Potent and Selective c‑Jun N‑Terminal Kinase (JNK) Inhibitors

Synthesis of Potent Bicyclic Bisarylimidazole c-Jun N-Terminal Kinase Inhibitors by Catalytic C−H Bond Activation

Inhibitors of c-jun-N-terminal kinase (JNK)

Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) Inhibitors

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases

Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

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