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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

Nature medicine, 1999-11, Vol.5 (11), p.1256-1263

1999

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Transcriptional Targeting to Anterior Pituitary Lactotrophic Cells Using Recombinant Adenovirus Vectors in Vitro and in Vivo in Normal and Estrogen/Sulpiride-Induced Hyperplasic Anterior Pituitaries

Endocrinology (Philadelphia), 2000-09, Vol.141 (9), p.3493-3505

2000

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Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas

The journal of clinical endocrinology and metabolism, 2000-03, Vol.85 (3), p.1296-1305

2000

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Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase : reduced cytotoxicity of a truncated HSV1-TK

Gene therapy, 2000-04, Vol.7 (8), p.679-685

2000

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Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells

Gene therapy, 2001-03, Vol.8 (6), p.469-476

2001

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Peripheral Infection with Adenovirus Causes Unexpected Long-Term Brain Inflammation in Animals Injected Intracranially with First-Generation, but Not with High-Capacity, Adenovirus Vectors: Toward Realistic Long-Term Neurological Gene Therapy for Chronic Diseases

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (13), p.7482-7487

2000

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Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges

Molecular therapy, 2005-08, Vol.12 (2), p.189-211

2005

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Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (10), p.4716-4721

2010

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Molecular Indetermination in the Transition to Error Catastrophe: Systematic Elimination of Lymphocytic Choriomeningitis Virus through Mutagenesis Does Not Correlate Linearly with Large Increases in Mutant Spectrum Complexity

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (20), p.12938-12943

2002

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Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma

Clinical pharmacology and therapeutics, 2010-08, Vol.88 (2), p.204-213

2010

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There Must Be a Way Out of Here: Identifying a Safe and Efficient Combination of Promoter, Transgene, and Vector Backbone for Gene Therapy of Neurological Disease

Molecular therapy, 2014-02, Vol.22 (2), p.246-247

2014

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Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors

Journal of Virology, 2001-10, Vol.75 (20), p.9723-9730

2001

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Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of Infectivity

Journal of Virology, 2000-09, Vol.74 (18), p.8316-8323

2000

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Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences

Gene therapy, 2003-06, Vol.10 (11), p.946-954

2003

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Current and future strategies for the treatment of malignant brain tumors

Pharmacology & therapeutics (Oxford), 2003-04, Vol.98 (1), p.71-108

2003

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Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

Human gene therapy, 2001-05, Vol.12 (7), p.839-846

2001

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Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction

Human gene therapy, 2006-05, Vol.17 (5), p.531

2006

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Strong Promoters Are the Key to Highly Efficient, Noninflammatory and Noncytotoxic Adenoviral-Mediated Transgene Delivery into the Brain in Vivo

Molecular therapy, 2000-10, Vol.2 (4), p.330-338

2000

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Viral vectors for gene delivery and gene therapy within the endocrine system

Journal of endocrinology, 2000-02, Vol.164 (2), p.103-118

2000

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Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses

Gene therapy, 2003-06, Vol.10 (11), p.933-934

Lowenstein, P R

2003

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The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors

Advances in pharmacology (1990), 2016, Vol.76, p.147-173

2016

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Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration

Molecular therapy, 2004-09, Vol.10 (3), p.507-524

2004

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Herpes Simplex Virus Type 1 Thymidine Kinase Sequence Fused to the lacZ Gene Increases Levels of β-Galactosidase Activity per Genome of High-Capacity but Not First-Generation Adenoviral Vectors In Vitro and In Vivo

Journal of Virology, 2009-02, Vol.83 (4), p.2004-2010

2009

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Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age

Brain research bulletin, 2005-12, Vol.68 (1-2), p.31-41

2005

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A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer

Gene therapy, 2003-09, Vol.10 (18), p.1616-1622

2003

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

Transcriptional Targeting to Anterior Pituitary Lactotrophic Cells Using Recombinant Adenovirus Vectors in Vitro and in Vivo in Normal and Estrogen/Sulpiride-Induced Hyperplasic Anterior Pituitaries

Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas

Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase : reduced cytotoxicity of a truncated HSV1-TK

Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells

Peripheral Infection with Adenovirus Causes Unexpected Long-Term Brain Inflammation in Animals Injected Intracranially with First-Generation, but Not with High-Capacity, Adenovirus Vectors: Toward Realistic Long-Term Neurological Gene Therapy for Chronic Diseases

Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges

Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo

Molecular Indetermination in the Transition to Error Catastrophe: Systematic Elimination of Lymphocytic Choriomeningitis Virus through Mutagenesis Does Not Correlate Linearly with Large Increases in Mutant Spectrum Complexity

Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma

There Must Be a Way Out of Here: Identifying a Safe and Efficient Combination of Promoter, Transgene, and Vector Backbone for Gene Therapy of Neurological Disease

Efficient Virus Extinction by Combinations of a Mutagen and Antiviral Inhibitors

Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of Infectivity

Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences

Current and future strategies for the treatment of malignant brain tumors

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction

Strong Promoters Are the Key to Highly Efficient, Noninflammatory and Noncytotoxic Adenoviral-Mediated Transgene Delivery into the Brain in Vivo

Viral vectors for gene delivery and gene therapy within the endocrine system

Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses

The Long and Winding Road: From the High-Affinity Choline Uptake Site to Clinical Trials for Malignant Brain Tumors

Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration

Herpes Simplex Virus Type 1 Thymidine Kinase Sequence Fused to the lacZ Gene Increases Levels of β-Galactosidase Activity per Genome of High-Capacity but Not First-Generation Adenoviral Vectors In Vitro and In Vivo

Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age

A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer

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