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Synthetic Approaches to the New Drugs Approved During 2015

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6480-6515

2017

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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.2005-2024

2016

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Synthetic approaches to the 2011 new drugs

Bioorganic & medicinal chemistry, 2013-06, Vol.21 (11), p.2795-2825

2013

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Identification of Cys255 in HIF‐1α as a novel site for development of covalent inhibitors of HIF‐1α/ARNT PasB domain protein–protein interaction

Protein science, 2012-12, Vol.21 (12), p.1885-1896

2012

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Esophageal tuberculosis induced dysphagia: a case report

BMC gastroenterology, 2022-03, Vol.22 (1), p.131-131, Article 131

2022

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Synthetic approaches to the 2009 new drugs

Bioorganic & medicinal chemistry, 2011-02, Vol.19 (3), p.1136-1154

2011

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Synthetic approaches to the 2010 new drugs

Bioorganic & medicinal chemistry, 2012-02, Vol.20 (3), p.1155-1174

2012

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Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (15), p.5114-5117

2012

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Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design

ACS medicinal chemistry letters, 2013-01, Vol.4 (1), p.91-97

2013

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Medicare Advantage in Soft Tissue Sarcoma May Be Associated with Worse Patient Outcomes

Journal of clinical medicine, 2023-08, Vol.12 (15), p.5122

2023

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Synthetic approaches to the 2014 new drugs

Bioorganic & medicinal chemistry, 2016-05, Vol.24 (9), p.1937-1980

2016

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Harnessing the Intrinsic Reactivity of 2‐Cyano‐Substituted Heteroarenes to Achieve Programmable Double Alkylation

Advanced synthesis & catalysis, 2020-04, Vol.362 (7), p.1502-1508

2020

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Characteristics of Very Young Patients Undergoing Total Hip Arthroplasty: A Contemporary Assessment

Arthroplasty today, 2024-02, Vol.25, p.101268-101268, Article 101268

2024

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An Updated Estimate of Total Hip and Total Knee Arthroplasty Inpatient Case Volume During the 2020 COVID-19 Pandemic in the United States

Arthroplasty today, 2024-04, Vol.26, p.101336-101336, Article 101336

2024

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Synthetic approaches to the 2013 new drugs

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (9), p.1895-1922

2015

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Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (4), p.1270-1274

2011

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Complications and Safety of Simultaneous Bilateral Total Knee Arthroplasty: A Patient Characteristic and Comorbidity-Matched Analysis

Journal of bone and joint surgery. American volume, 2023-07, Vol.105 (14), p.1072-1079

2023

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Tranexamic Acid Is Safe in Patients with a History of Venous Thromboembolism Undergoing Total Joint Arthroplasty

Journal of bone and joint surgery. American volume, 2024-01, Vol.106 (1), p.30-38

2024

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Preoperative Laboratory Values Predicting Periprosthetic Joint Infection in Morbidly Obese Patients Undergoing Total Hip or Knee Arthroplasty

Journal of bone and joint surgery. American volume, 2024-07, Vol.106 (14), p.1317-1327

2024

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Medicaid Patients Undergo Total Joint Arthroplasty at Lower-Volume Hospitals by Lower-Volume Surgeons and Have Poorer Outcomes

Journal of bone and joint surgery. American volume, 2023-07, Vol.105 (13), p.979-989

2023

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4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (20), p.6096-6099

2010

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Synthetic approaches to the 2008 new drugs

Mini reviews in medicinal chemistry, 2009-12, Vol.9 (14), p.1655-1675

2009

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Higher Blood Glucose Levels on the Day of Surgery Are Associated with an Increased Risk of Periprosthetic Joint Infection After Total Hip Arthroplasty

Journal of bone and joint surgery. American volume, 2024-02, Vol.106 (4), p.276-287

2024

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Perioperative Dexamethasone is Associated With a Decreased Risk of Pulmonary Embolism and Deep Vein Thrombosis Following Total Joint Arthroplasty: An Analysis of 70,000 High-Risk Patients

The Journal of arthroplasty, 2024-10, Vol.39 (10), p.2446-2451.e1

2024

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Same-Day Total Joint Arthroplasty in the United States From 2016 to 2020: The Impact of the Medicare Inpatient Only List and the COVID-19 Pandemic

The Journal of arthroplasty, 2024-04, Vol.39 (4), p.858-863.e2

2024

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Synthetic Approaches to the New Drugs Approved During 2015

Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Synthetic approaches to the 2011 new drugs

Identification of Cys255 in HIF‐1α as a novel site for development of covalent inhibitors of HIF‐1α/ARNT PasB domain protein–protein interaction

Esophageal tuberculosis induced dysphagia: a case report

Synthetic approaches to the 2009 new drugs

Synthetic approaches to the 2010 new drugs

Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors

Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design

Medicare Advantage in Soft Tissue Sarcoma May Be Associated with Worse Patient Outcomes

Synthetic approaches to the 2014 new drugs

Harnessing the Intrinsic Reactivity of 2‐Cyano‐Substituted Heteroarenes to Achieve Programmable Double Alkylation

Characteristics of Very Young Patients Undergoing Total Hip Arthroplasty: A Contemporary Assessment

An Updated Estimate of Total Hip and Total Knee Arthroplasty Inpatient Case Volume During the 2020 COVID-19 Pandemic in the United States

Synthetic approaches to the 2013 new drugs

Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors

Complications and Safety of Simultaneous Bilateral Total Knee Arthroplasty: A Patient Characteristic and Comorbidity-Matched Analysis

Tranexamic Acid Is Safe in Patients with a History of Venous Thromboembolism Undergoing Total Joint Arthroplasty

Preoperative Laboratory Values Predicting Periprosthetic Joint Infection in Morbidly Obese Patients Undergoing Total Hip or Knee Arthroplasty

Medicaid Patients Undergo Total Joint Arthroplasty at Lower-Volume Hospitals by Lower-Volume Surgeons and Have Poorer Outcomes

4-Methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors

Synthetic approaches to the 2008 new drugs

Higher Blood Glucose Levels on the Day of Surgery Are Associated with an Increased Risk of Periprosthetic Joint Infection After Total Hip Arthroplasty

Perioperative Dexamethasone is Associated With a Decreased Risk of Pulmonary Embolism and Deep Vein Thrombosis Following Total Joint Arthroplasty: An Analysis of 70,000 High-Risk Patients

Same-Day Total Joint Arthroplasty in the United States From 2016 to 2020: The Impact of the Medicare Inpatient Only List and the COVID-19 Pandemic

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