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Targeting oncogenic Myc as a strategy for cancer treatment

Signal transduction and targeted therapy, 2018-02, Vol.3 (1), p.5-7, Article 5

2018

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Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat

Signal transduction and targeted therapy, 2020-07, Vol.5 (1), p.124-124, Article 124

2020

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Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

Cell reports (Cambridge), 2017-12, Vol.21 (13), p.3819-3832

2017

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EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Nature communications, 2022-01, Vol.13 (1), p.12-12, Article 12

2022

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ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation

The Journal of pathology, 2015-01, Vol.235 (1), p.90-100

2015

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Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival

Molecular cell, 2016-11, Vol.64 (3), p.493-506

2016

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USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression

Oncogene, 2021-11, Vol.40 (46), p.6417-6429

2021

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pH-Sensitive Docetaxel-Loaded d‑α-Tocopheryl Polyethylene Glycol Succinate–Poly(β-amino ester) Copolymer Nanoparticles for Overcoming Multidrug Resistance

Biomacromolecules, 2013-08, Vol.14 (8), p.2636-2646

2013

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Differential regulation of microRNA stability

RNA (Cambridge), 2010-05, Vol.16 (5), p.1032-1039

2010

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Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

Nature communications, 2024-03, Vol.15 (1), p.2377-2377

2024

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WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia

Haematologica (Roma), 2021-07, Vol.106 (7), p.1816

2021

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Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis

Clinical cancer research, 2017-07, Vol.23 (14), p.3834-3846

2017

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Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2

Oncotarget, 2015-12, Vol.6 (38), p.40655-40666

2015

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Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma

Oncotarget, 2014-09, Vol.5 (18), p.8429-8441

2014

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MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategies

Blood science, 2021-07, Vol.3 (3), p.65-70

2021

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SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Nature communications, 2018-10, Vol.9 (1), p.4281-15, Article 4281

2018

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Intertwined regulation between RNA m6A modification and cancer metabolism

Cell insight, 2023-02, Vol.2 (1), p.100075-100075, Article 100075

2023

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Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia

Scientific reports, 2016-05, Vol.6 (1), p.26510-26510, Article 26510

2016

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The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation

Molecular cancer therapeutics, 2015-01, Vol.14 (1), p.289-297

2015

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α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

Cancers, 2022-06, Vol.14 (12), p.2983

2022

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Genome-Wide Analysis Identifies Rag1 and Rag2 as Novel Notch1 Transcriptional Targets in Thymocytes

Frontiers in cell and developmental biology, 2021-07, Vol.9, p.703338-703338

2021

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A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival

iScience, 2024-01, Vol.27 (1), p.108571-108571, Article 108571

2024

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N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation

Toxicology and applied pharmacology, 2014-11, Vol.280 (3), p.475-483

2014

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Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia

International journal of hematology, 2011-08, Vol.94 (2), p.118-125

2011

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DcpS scavenger decapping enzyme can modulate pre-mRNA splicing

RNA (Cambridge), 2008-06, Vol.14 (6), p.1132-1142

2008

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Targeting oncogenic Myc as a strategy for cancer treatment

Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation

Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival

USP29 coordinates MYC and HIF1α stabilization to promote tumor metabolism and progression

pH-Sensitive Docetaxel-Loaded d‑α-Tocopheryl Polyethylene Glycol Succinate–Poly(β-amino ester) Copolymer Nanoparticles for Overcoming Multidrug Resistance

Differential regulation of microRNA stability

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia

Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2

Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma

MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategies

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Intertwined regulation between RNA m6A modification and cancer metabolism

Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia

The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation

α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

Genome-Wide Analysis Identifies Rag1 and Rag2 as Novel Notch1 Transcriptional Targets in Thymocytes

A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survival

N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation

Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia

DcpS scavenger decapping enzyme can modulate pre-mRNA splicing

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