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Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (13)

2021

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Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy

Investigative ophthalmology & visual science, 2021-09, Vol.62 (12), p.15-15

2021

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Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model

Investigative ophthalmology & visual science, 2020-08, Vol.61 (10), p.31-31

2020

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Autophagic dysregulation in glaucomatous trabecular meshwork cells

Biochimica et biophysica acta, 2015-03, Vol.1852 (3), p.379-385

2015

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MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch

Biochimica et biophysica acta, 2014-06, Vol.1843 (6), p.1054-1062

2014

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Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy

Scientific reports, 2017-07, Vol.7 (1), p.6656-11, Article 6656

2017

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Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge

PloS one, 2013-07, Vol.8 (7), p.e68668-e68668

2013

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Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models

Cell death & disease, 2023-08, Vol.14 (8), p.554-11, Article 554

2023

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Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress

Investigative ophthalmology & visual science, 2010-12, Vol.51 (12), p.6483-6495

2010

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Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model

Cell death discovery, 2018-07, Vol.4 (1), p.14-13, Article 75

2018

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The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up

Progress in retinal and eye research, 2022-09, Vol.90, p.101064-101064, Article 101064

2022

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H2O2 Signaling-Triggered PI3K Mediates Mitochondrial Protection to Participate in Early Cardioprotection by Exercise Preconditioning

Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-16

2018

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Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma

Journal of clinical medicine, 2020-12, Vol.10 (1), p.78

2020

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Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells

PloS one, 2012-04, Vol.7 (4), p.e34792-e34792

2012

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Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells

Oxidative medicine and cellular longevity, 2020, Vol.2020 (2020), p.1-21

2020

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The autophagic lysosomal system in outflow pathway physiology and pathophysiology

Experimental eye research, 2016-03, Vol.144, p.29-37

Liton, Paloma B.

2016

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Autophagy and mechanotransduction in outflow pathway cells

Experimental eye research, 2017-05, Vol.158, p.146-153

2017

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The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

Autophagy, 2020-07, Vol.16 (7), p.1248-1261

2020

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Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway

Autophagy reports, 2023-12, Vol.2 (1)

2023

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Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells

Scientific reports, 2019-11, Vol.9 (1), p.16092-14, Article 16092

2019

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Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells

Journal of ocular pharmacology and therapeutics, 2014-03, Vol.30 (2-3), p.246-253

2014

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Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: Implications for glaucoma pathogenesis

Autophagy, 2013-04, Vol.9 (4), p.581-594

2013

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Cultured Porcine Trabecular Meshwork Cells Display Altered Lysosomal Function When Subjected to Chronic Oxidative Stress

Investigative ophthalmology & visual science, 2008-09, Vol.49 (9), p.3961-3969

2008

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Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

Autophagy, 2009-01, Vol.5 (1), p.122-124

2009

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Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells

Biochemical and biophysical research communications, 2003-08, Vol.308 (2), p.346-352

2003

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Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells

Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy

Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model

Autophagic dysregulation in glaucomatous trabecular meshwork cells

MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch

Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy

Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge

Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models

Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress

Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model

The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up

H2O2 Signaling-Triggered PI3K Mediates Mitochondrial Protection to Participate in Early Cardioprotection by Exercise Preconditioning

Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma

Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells

Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells

The autophagic lysosomal system in outflow pathway physiology and pathophysiology

Autophagy and mechanotransduction in outflow pathway cells

The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway

Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells

Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: Implications for glaucoma pathogenesis

Cultured Porcine Trabecular Meshwork Cells Display Altered Lysosomal Function When Subjected to Chronic Oxidative Stress

Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells

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